Quantitative determination of amphetamines, cocaine, and opiates in human hair by gas chromatography/mass spectrometry

Hair of young subjects (N = 36) suspected for drug abuse was analysed for morphine, codeine, heroin, 6-acetylmorphine, cocaine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA). The analysis of morphine, codeine, heroin, 6-acetylmorphine, cocaine, and methadone in hair included incubation in methanol, solid-phase extraction, derivatisation by the mixture of propionic acid anhydride and pyridine, and gas chromatography/mass spectrometry (GC/MS). For amphetamine, methamphetamine, MDA, MDMA, and MDEA analysis, hair samples were incubated in 1M sodium hydroxide, extracted with ethyl acetate, derivatised with heptafluorobutyric acid anhydride (HFBA), and assayed by GC/MS. The methods were reproducible (R.S.D. = 5.0-16.1%), accurate (85.1-100.6%), and sensitive (LoD = 0.05-0.30ng/mg). The applied methods confirmed consumption of heroin in 18 subjects based on positive 6-acetylmorphine. Among these 18 heroin consumers, methadone was found in four, MDMA in two, and cocaine in two subjects. Cocaine only was present in two, methadone only in two, methamphetamine only in two, and MDMA only in seven of the 36 subjects. In two out of nine coloured and bleached hair samples, no drug was found. Despite the small number of subjects, this study has been able to indicate the trend in drug abuse among young people in Croatia.     

Marginally discriminated: the role of outcome tests in European jurisdiction

For decades, racial profiling has been subject of intense debate in US jurisdiction. Recently, outcome tests based on economic models have contributed to the legal discourse. However, it is not readily obvious if and to what extent they also pertain to European jurisdiction, where racial profiling has only as of late stirred up controversy. In a comprehensive examination of their basic building blocks, this paper illustrates why the these tests are not particularly suited for the European case. The models are tailored to identify racial prejudice but are unfit to provide evidence of statistical discrimination, reflecting their adaption to the current US legal approach. A simple alternative test remedies this shortcoming and manages to inform the European jurisdiction.     

From persecutors to protectors: Human rights and the F&M Global Barometer of Gay RightsTM (GBGR)

Sexual minorities are the most vulnerable minorities on the planet. Their existence challenges cultural norms, traditions, and power structures. They have been treated as social pariahs and scapegoats for the economic, political, or social ills in their countries. However, countries vary widely in the extent to which they are protective or repressive toward lesbian, gay, bisexual, and transgender individuals. This article systematically analyzes the global persecution and protection of sexual minorities through the application of the F&M Global Barometer of Gay Rights^TM (GBGR). Using GBGR world data from 2011 to 2014, we document the variance in levels of state and societal persecution and protection of sexual minorities in 188 countries. Our findings suggest that having a higher life expectancy, a democratic system, a lower percentage of rural population, and lower religiosity are significant predictors of whether a country will be more rights-protective toward its sexual minorities.     

Subnational Variations in Government-Nonprofit Relations: A Comparative Analysis of Regional Differences within Russia

Abstract

This article discusses the evolution of government-nonprofit relations at the regional level in Russia against the background of national-level restrictions on NGOs. Russia recently also introduced supportive policies and the article aims to trace the regional administrations’ reactions to the dual realities of the federal government’s posture towards nonprofits. Considerable variation was found in regional government-nonprofit relationships as well as deviation from national policy stances. Using a subnational comparative framework, this article addresses a gap in the literature and lays the groundwork for future cross-national comparisons of subnational variations of government-nonprofit relations in other authoritarian and hybrid political regimes.     

Ethical analysis of a curious event of a forensic case becoming an involuntarily hospitalized psychiatric patient

It is not uncommon in forensic psychiatry that the duty to care for the patient conflicts with the responsibility to the court, or the duty to protect the public from harm from the potentially dangerous patient-offender. This paper exemplifies the scenario of what happens when the line between forensic and clinical psychiatry is crossed and whether crossing that boundary can be justified. Ethical discussion also embodies and clarifies the issues of unjustified violation of the patients’ autonomy and an undue infringement on their right to liberty on the arbitrary basis of existing or perceived mental illness. The paper provides an in-depth analysis of the issues of physicians’ conflicting duties, vulnerability of patient-offenders, and their human rights in the light of court orders and involuntary hospitalizations.

I argue that in order to promote ethical decision-making we must establish clear rules and guidelines for psychiatric practice, separate conflicting roles, and provide sufficient training of health-care professionals regarding topics of human rights and legislation governing clinical and forensic psychiatric practice. Empowering patients and enhancing their rights to autonomy and liberty can also be potent tools of promotion and protection of their human rights and prevention of ethical breaches in practice.     

Traumatic testicular displacement in motorcycle drivers

Testicular displacement is a rare clinical presentation of blunt scrotal injury that may take place in road traffic accidents involving motorcycle occupants. We are presenting two cases of motorcycle occupant fatalities, 21 and 24 years of age, where testicular displacement and other signs of groin trauma have been determined. In both cases, discrete external signs of scrotal trauma were noted on examination, while unilateral and bilateral traumatic testicular displacement, respectively, have been documented at autopsy. For motorcycle occupants involved in collision, it is necessary to perform a thorough analysis of injuries, in particular to look for specific trauma arising from fuel-tank impact to genitalia and/or groin. These injuries are of great medico-legal importance both at postmortem and in clinical cases involving motorcycle occupants involved in collision.     

Positive identification by a skull with multiple epigenetic traits and abnormal structure of the neurocranium, viscerocranium, and the skeleton

Wormian bones are small ossicles appearing within the cranial sutures in more than 40% of skulls, most commonly at the lambdoid suture and pterion. During the skeletal analysis of an unidentified male war victim, we observed multiple wormian bones and a patent metopic suture. Additionally, the right elbow was deformed, probably as a consequence of an old trauma. The skull was analyzed by cranial measurements and computerized tomography, revealing the presence of cranial deformities including hyperbrachicrania, localized reduction in hemispheral widths, increased cranial capacity, and sclerosis of the viscerocranium. Besides unique anatomical features and their anthropological value, such skeletal abnormalities also have a forensic value as the evidence to support the final identification of the victim.     

Changes in the relative importance of dynamic risk factors for recidivism during adolescence

This study examined which dynamic risk factors for recidivism play an important role during adolescence. The sample consisted of 13,613 American juveniles who had committed a criminal offense. The results showed that the importance of almost all dynamic risk factors, both in the social environment domain (school, family, relationships) and in the individual domain (attitude, skills, aggressiveness), decreased as juveniles grew older. Therefore, the potential effect of an intervention aimed at these factors will also decrease as juveniles grow older. The relative importance of the risk factors also changed: In early adolescence, risk factors in the family domain showed the strongest association with recidivism, whereas in late adolescence risk factors in the attitude, relationships, and school domain were more strongly related to recidivism. These results suggest that the focus of an intervention needs to be attuned to the age of the juvenile to achieve the maximum potential effect on recidivism.     

Unnatural and Violent Death in Cases with High Blood Alcohol Concentration— Autopsy Study

The use of alcohol increases the risk of dying from unnatural or violent causes. The presented study explored the distribution of age, gender, cause, and circumstances of death in persons who died in an unnatural and violent manner, with a blood alcohol concentration (BAC) higher than 0.3 g/dL, and where the cause of death was not alcohol intoxication. We defined the control (0 < BAC < 0.3 g/dL) and study (BAC ≥ 0.3 g/dL) groups, as in subjects with these concentrations, there is a significant risk of gross intoxication, stupor, and death. The subjects from the study group were older, with no difference in gender distribution. Traffic accidents were the most common fatal event in both groups, followed by suicides. Other accidents (choking on food and exposure to fire) were more frequent in the study group. Compared to the control group, subjects from the study group were older persons whose deaths were mainly accidental.