High prevalence of 6-acetylmorphine in morphine-positive oral fluid specimens

Identification of 6-acetylmorphine, a specific metabolite of heroin, is considered to be definitive evidence of heroin use. Although 6-acetylmorphine has been identified in oral fluid following controlled heroin administration, no prevalence data is available for oral fluid specimens collected in the workplace. We evaluated the prevalence of positive test results for 6-acetylmorphine in 77,218 oral fluid specimens collected over a 10-month period (January-October 2001) from private workplace testing programs. Specimens were analyzed by Intercept immunoassay (cutoff concentration=30 ng/ml) and confirmed by GC-MS-MS (cutoff concentrations=30 ng/ml for morphine and codeine, and 3 ng/ml for 6-acetylmorphine). Only morphine-positive oral fluid specimens were tested by GC-MS-MS for 6-acetylmorphine. A total of 48 confirmed positive morphine results were identified. An additional 107 specimens were confirmed for codeine only. Of the 48 morphine-positive specimens, 32 (66.7%) specimens were positive for 6-acetylmorphine. Mean concentrations (+/-S.E.M.) of morphine, 6-acetylmorphine and codeine in the 32 specimens were 755+/-201, 416+/-168 and 196+/-36 ng/ml, respectively. Concentrations of 6-acetylmorphine in oral fluid ranged from 3 to 4095 ng/ml. The mean ratio (+/-S.E.M.) of 6-acetylmorphine/morphine was 0.33+/-0.06. It is suggested that, based on controlled dose studies of heroin administration, ratios >1 of 6-acetylmorphine/morphine in oral fluid are consistent with heroin use within the last hour before specimen collection. The confirmation of 6-acetylmorphine in 66.7% of morphine-positive oral fluid specimens indicates that oral fluid testing for opioids may offer advantages over urine in workplace drug testing programs and in testing drugged drivers for recent heroin use.     

Intermediate punishment: Redistributing or extending social control?

During the past two decades, a major area of debate has been about the meaning and consequences of the community corrections movement that has now evolved into intermediate punishment. A question underlying this debate is whether or not this movement accomplishes its expressed purpose of reducing reliance on prisons by redistributing control into the community or merely extends community control without altering previous reliance on prisons. This study assesses Florida's intermediate punishment strategy of home confinement. Data from observations of program practices and interviews with home confinement officers, offenders on the program and various family members living in the home address the operational features of the program. Pre and post program statistics (1980–1987) on state population, felony convictions and forms of correctional sanctions explore the program's impact upon the state's characteristic sanctioning trends. The findings provide no support that home confinement has reduced Florida's reliance on prisons. Specifically, throughout the decade of the 1980s, and despite the operation of a home confinement program that has involved over 100,000 offenders, Florida's use of prisons experienced major increases disproportionate to the state's population, and conviction increases. The paper concludes with discussion of ironies associated with correctional reforms and related empirical and theoretical implications.     

International norms on execution of the insane and the mentally retarded

Conclusion Victor Hugo considered the death penalty to be the hallmark of barbarity. 104 International human rights law clearly contemplates abolition of the death penalty. To some extent, it has succeeded in promoting universal and imperative norms, as in the case of the prohibitions on torture and slavery. 105 With respect to the death penalty, results have been more gradual and the effort has met with more opposition. Although international norms now exist prohibiting the death penalty, 106 they are not yet widely ratified. This is why international organizations dedicated to the promotion of human rights have insisted upon strict limitation of the death penalty, including its total exclusion for certain categories, such as juveniles, pregnant women, the elderly, and the insane.No treaty provision exists to exclude the insane from the death penalty. The conclusion that this prohibition represents a customary norm is an important one, with consequences not only in international law but also in domestic law since many states consider customary international law to be a part of their domestic law. Wherever a court concludes that in the absence of any domestic statutory provision to the contrary, customary international human rights law prohibits execution of an insane prisoner, a small step will be taken away from the barbarism lamented by Hugo.B.A., University of Toronto 1972; M.A., University of Toronto 1973; LL.B., University of Montreal 1983; LL.M., University of Montreal 1990; LL.D., University of Montreal 1993.