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581.
Allard MW Polanskey D Miller K Wilson MR Monson KL Budowle B 《Forensic science international》2005,148(2-3):169-179
The scientific working group on DNA analysis Methods (SWGDAM) mitochondrial DNA (mtDNA) population data set is used to infer the relative rarity of control region mtDNA profiles obtained from evidence samples and of profiles used for identification of missing persons. In this study, the African American haplogroup patterns in the SWGDAM data were analyzed in a phylogenetic context to determine relevant single nucleotide polymorphisms (SNPs) and to describe haplogroup distributions for Africans observed in these data sets. Over 200 SNPs (n=217) were observed in the African American data set (n=1148). These SNPs ranged from having 1-39 changes in the phylogenetic tree, with sites 152 and 16519 being the most variable. On average there were 5.8 changes for a character on the tree. The most variable sites (with 19 or more changes each) observed included 16093, 16129, 16189, 16311, 16362, 16519, 146, 150, 152, 189, and 195. These rapidly changing sites are consistent with other published analyses. Only 34 SNPs are needed to identify all clusters containing 10 or more individuals in the African American data set. The results show that the African American SWGDAM mtDNA data set contains variation consistent with that described in continental African populations. Thirteen of the 18 haplogroups previously observed in African populations were observed and include: L1a, L1b, L1c, L2a, L2b, L2c, L3b, L3d, L3e1, L3e2, L3e3, L3e4 and L3f. Haplogroup L2a is the most commonly observed cluster (18.8%) in the African American data set. The next most common haplogroups in the African American data set include the clusters L1c (11.0%), L1b (9.1%), L3e2 (9.0%) and L3b (8.1%). Approximately 8% of the haplogroups observed within African Americans were common in European Caucasians or East Asians; these were H (n=32), J (n=4), K (n=5), T (n=2), U5 (n=6), U6 (n=9 also known from North Africa), A (n=12), B (n=7), C (n=4), and M (n=16), respectively. The European Caucasian and East Asian haplogroups are expected due to admixture between individuals with recent ancestry in Western Eurasia and sub-Saharan Africa. The genetic characterization of these relevant data sets is fully consistent with other published mtDNA genetic variation. The sequence diversity observed in this data set makes it a valuable tool for forensic applications. 相似文献
582.
Wilson JF Toseland PA Capps NE Sandle LN Smith BL Sweeney G Thomson AH Watson ID Williams J 《Forensic science international》2001,121(1-2):27-32
A mean of 44 members of the United Kingdom national external quality assessment scheme (UKNEQAS) for toxicology reported analytical findings on 10 toxicological cases circulated between December 1995 and February 2000. Material distributed usually consisted of a 5ml blood and a 20ml urine sample simulated by quantitative addition of drugs and their metabolites to material donated by volunteers and patients. The samples were accompanied by a brief outline of the circumstances surrounding the case. Laboratories were requested to report their analytical findings, list methods of analysis, and provide interpretation of their findings. The mean overall success rate for identification of drugs or their pharmacological group was 76%, failure being largely by laboratories providing an immunoassay-based screening service for a fixed range of drug groups. The latter laboratories indicated that cases would be referred to regional toxicology centres for further investigation or confirmation. The coefficient of variation of measurements was <7% for routine analytes, such as ethanol and paracetamol, but 26-44% for tricyclics and opiates. There were 3% false positive reports. The quantity and content of interpretative comment provided by the laboratories was very variable. A number provide nothing in addition to the analytical result. 相似文献
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G. P. Wilson 《The Modern law review》1971,34(6):635-641
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In the past decade, the forensic use of hypnosis to enhance the memories of victims, witnesses, and defendants has sharply increased. A great deal of controversy surrounds this issue. Some commentators argue that testimony derived from hypnosis should not be allowed as evidence because of its inherent unreliability and the unduly powerful impact it may have on a jury. In the present research, we used a jury simulation technique to study the impact that a hypnotically refreshed witness has upon jurors' decision making. A major finding is that jurors view hypnotic testimony with a certain amount of skepticism. In some respects, its impact is comparable to that of testimony based on delayed recall, and rarely does it have the impact of testimony from an immediate report. In addition, jurors' judgments about hypnotically refreshed testimony affected the way they evaluated other evidence at trial: Jurors who learned that a prosecution witness had been hypnotized were less believing ofother prosecution witnesses than were jurors not exposed to hypnotic testimony. The forensic application of these findings is discussed.This research was supported by a grant from the National Science Foundation, Law and Social Sciences Program. We thank Jane Goodman, Doug Leber, Bonnie Sawnson, Russ Wade, Karen Guest, Jonna Barsanti, Don Kline, Elaine Sullivan, and David Kuykendall for their help at various stages of the project. 相似文献