Politische Steuerung und akteurzentrierter Institutionalismus

Der vorliegende Beitrag beschäftigt sich mit Aspekten der steuerungstheoretischen Debatte. In traditioneller Hinsicht wurde, insbesondere ausgeprägt in der kontinentaleuropäischen Diskussion, den staatlichen Administrationen eine steuerungspolitische Bedeutung beigemessen. Heute geht es jedoch darum, sich auf die steuerungspolitischen Fähigkeiten zu beziehen, die in grossen gesellschaftlichen Teilsystemen angelegt sind und Überlegungen über die Qualität von "gesellschaftlicher Selbstkoordination und -steuerung" anzustellen. Es zeigt sich ferner, wie bedeutsam die in Verhandlungssystemen (Föderalismus; Europäische Union) angelegten, polyvalenten steuerungspolitischen Potentiale und Instrumente sind.     

Electrospray-ionization MS/MS library of drugs as database for method development and drug identification

An ESI MS/MS library of 800 compounds has been developed and a collection of data is now available for Analyst 1.4 and higher. Compounds include forensically important drugs, such as illegal drugs, some deuterated analogues, hypnotics, amphetamines, benzodiazepines, neuroleptics, antidepressants and many others. For setting up the library of product ion spectra, 20-200 ng of the compounds have been injected either by flow injection or via a short LC-column, the precursor ions were chosen from the Q1 scan spectra, and product ion spectra were generated by CID in the collision cell using three different collision energies (20, 35 and 50 eV). Three spectra of each compound have been collected and compound names, CAS numbers, formulas and molecular weights have been added in the database, which has been generated by the Analyst software. The library can be used for compound identification during general unknown screening analysis by combination of Q1 scan techniques and subsequent MS/MS analysis in a second analytical run. Quantitative procedures for multi drug analysis using Multiple Reaction Monitoring can be established by selection of product ions and suitable collision energies from the library. For publication of the spectra, PDF-files have been generated and can be viewed on-line as supplementary data or from the website in alphabetical order: (supplementary data, should be made available via ELSEVIER-WEBSITE or via ).     

An optional European contract law code: Advantages and disadvantages

Should the EU introduce an Optional European Contract Law Code and what should it look like? By applying economic theories of federalism and regulatory competition (legal federalism), it is shown why an Optional Code would be a very suitable legal instrument within a two-level European System of Contract Laws. By allowing private parties’ choice of law to a certain extent, it can combine the most important advantages of centralisation and decentralisation of competences for legal rules. Through differentiated analyses of three kinds of contract law rules (mandatory substantive rules, mandatory information rules and facilitative law), important conclusions can be reached: which kinds of contract law rules are most suitable to be applied on an optional basis (e.g. facilitative law) and which might be less so (e.g. a core of information regulations). Furthermore a number of additional general conclusions about the design and scope of an Optional EU Code and some conclusions in regard to sales law are derived.     

Das neue Raumordnungsgesetz

Zum Jahreswechsel wurde das neue Raumordnungsgesetz verkündet, zur Jahresmitte wird das Gesetz in vollem Umfang in Kraft treten. Trotz mancher Verbesserungen im Detail ist es dem Gesetzgeber jedoch nicht gelungen, die rudiment?re Rolle des Bundes in der Raumentwicklungspolitik nennenswert aufzuwerten. Insgesamt best?tigt das in v?lligem Konsens von Bund und L?ndern ausgehandelte Gesetz die Befürchtung, dass die durch die F?deralismusreform 2006 geschaffenen L?nderabweichungsrechte die f?deralen Verantwortlichkeiten keineswegs entflechten, sondern vielmehr bereits im Gesetzgebungsverfahren einen kompromisshaften Konsens von L?ndern und Bund erzwingen.     

Nationale und europäische Anforderungen an Umweltbeiträge in der Verkehrsplanung

Ohne Zusammenfassung     

Self-enforcing norms and efficient non-cooperative collective action in the provision of public goods

We show how norms can solve the distributional conflict inside a group in an anarchic environment and yield efficient coordination of collective action in a conflict with an external competitor. The equilibrium of the fully non-cooperative game with finite horizon has two interesting features. First, one of the players assumes a central role that resembles the role of the ??big-man?? in some primitive stateless societies. Second, the group members?? contributions to collective output and the payments from the big-man to these members seemingly look like reciprocal behavior, even though they are driven by narrowly selfish preferences.     

Ensuring the safe and effective FDA regulation of fecal microbiota transplantation

Scientists, policymakers, and medical professionals alike have become increasingly worried about the rise of antibiotic resistance, and the growing number of infections due to bacteria like Clostridium difficile, which cause a significant number of deaths and are imposing increasing costs on our health care system. However, in the last few years, fecal microbiota transplantation (FMT), the transplantation of stool from a healthy donor into the bowel of a patient, has emerged as a startlingly effective means to treat recurrent C. difficile infections. At present, the FDA is proposing to regulate FMT as a biologic drug. However, this proposed classification is both underregulatory and overregulatory. The FDA''s primary goal is to ensure that patients have access to safe, effective treatments—and as such they should regulate some aspects of FMT more stringently than they propose to, and others less so. This essay will examine the nature of the regulatory challenges the FDA will face in deciding to regulate FMT as a biologic drug, and will then evaluate available policy alternatives for the FDA to pursue, ultimately concluding that the FDA ought to consider adopting a hybrid regulatory model as it has done in the case of cord blood.