Testing for anabolic steroids in hair from two bodybuilders.

Two male bodybuilders were recently arrested by the French customs in Strasbourg (France) in possession of 2050 tablets and 251 ampoules of various anabolic steroids. It was claimed that the steroids were for personal use and not for trafficing as suggested by the police. Urine and hair specimens were collected from both suspects to clarify the claims. Nandrolone, stanozolol, testosterone and their corresponding metabolites were identified in the urine of both subjects. After decontamination, the hair was hydrolyzed by sodium hydroxide in presence of deuterated internal standards. After extraction with ethyl acetate and silylation, the drugs were identified by GC-MS in the electron impact mode. Hair from both males were positive for nandrolone (196 and 260 pg/mg), testosterone (46 and 71 pg/mg) and stanozolol (135 and 156 pg/mg), clearly indicating steroids abuse. Although not yet recognized by the International Olympic Committee, hair analysis may be a useful adjunct to conventional drug testing in urine from athletes.     

Rechtsschutz im europäischen Kontrollverbund am Beispiel der FFH-Gebietsfestsetzungen

Verbundförmig durchgeführte Verwaltungsverfahren im europäischen Mehrebenenverwaltungssystem nehmen zunehmend komplexere Gestaltungsformen an, was weitreichende Auswirkungen auch auf den Rechtsschutz Betroffener hat. Der vorliegende Beitrag untersucht am Beispiel des europäischen Naturschutzrechts, welche Rechtsschutzmöglichkeiten betroffene Grundstückseigentümer in verbundförmig durchgeführten Verwaltungsverfahren offen stehen. Dabei wird deutlich, dass ein kohärentes Rechtsschutzsystem durchaus vorhanden ist, wenngleich seine Inanspruchnahme nicht unerhebliche Schwierigkeiten aufwirft.     

B. Reviews and notes of recent bibliographies

i. Islamic Bindings & Bookmaking: A Catalogue of an Exhibition, The Oriental Institute, The University of Chicago, May 18 — August 18, 1981. By Gulnar Bosch, John Carswell and Guy Petheridge. Chicago, 1981. pp.xii, 235, 177 photographs, 15 colour plates, 15 figures. $40.OO (hard cover), $20.00 (soft cover) plus postage and handling charges (foreign surface mail $3.10 and £2.80 respectively). Inquiries and orders to: The Oriental Institute (Attn.: Museum Office), 1155 E. 58th St., Chicago IL 60637, USA.

ii. A Book World Directory of the Arab Countries, Turkey and Iran. Compiled by Anthony Rudkin and Irene Butcher. London, Mansell/Detroit, Gale, 1981. pp.xiv, 143.

iii. Islamic Revolution or Revolutionary Islam in Iran, A Selected and Annotated Bibliography of Political Publications from the Overthrow of the Shah until his Death. By Wolfgang Behn. Berlin, “Ayidok”, 1980. pp.118.

iv. A Brief Guide to Sources for the Study of Afghanistan in the India Office Records. By Lesley Hall. London, India Office Library and Records, 1981. pp.v, 60. £4.00.

v. Scholars’ Guide to Washington, D.C. for Middle Eastern Studies. Egypt, Sudan, Jordan, Lebanon, Syria, Iraq, the Arabian Peninsula, Israel, Turkey, Iran. (Scholars’ Guide to Washington, D.C, No.7) . By Steven R. Dorr. Washington, D.C., Woodrow Wilson International Center for Scholars, Smithsonian Institution Press, 1981. pp.xiii, 540,2. $27.50 (cloth), $12.5O (paper).     

Analytical strategy for detecting doping agents in hair

Lists of banned classes of doping agents are released by the International Olympic Committee, adopted by other sports authorities and updated regularly, including the substance classes stimulants, narcotics, diuretics, anabolic agents, peptide hormones, beta-blockers etc. There are different classes of restriction: anabolic and masking agents (anabolic steroids, diuretics etc.) are always banned for athletes regardless of their topical activity (training or competition) several substances are permitted with certain restrictions (caffeine below a cut-off value, or inhalation of some beta 2 agonists) beta-blockers are prohibited in competitions of certain sports disciplines the majority of the substances (stimulants, narcotics etc.) is prohibited during competitions, so that they do not have to be analysed in out-of-competition samples. A differentiation between training and competition period is impossible by means of hair analysis due to the uncertainty of (especially short-term) kinetic considerations related to hair growth. Therefore, the analytical identification of doping relevant substances in hair is not always a sufficient criterion for a doping offence and the identification of stimulants, beta-blockers etc. in hair would be entirely irrelevant. The most interesting target substances are certainly the anabolic agents, because their desired action (enhanced muscle strength) lasts longer than the excretion, leading to sophisticated procedures to circumvent positive analytical results in competition control. Besides the analysis of out-of-competition control samples, the long term detection of steroids in hair could provide complementary information. An analytical approach to the identification of exogenous steroids in hair requires consideration of the presence of many other steroids in the hair matrix interfering the analysis at trace levels, and of a limited chemical stability. The analysis of endogenous steroids in hair appears to be even more complicated, because the possibility of many biotransformation reactions from (into) other precursors (metabolites) has to be taken into account. Precursor substances of anabolic steroids (especially esters as application forms) are very promising analytical targets of hair analysis, because they can only be detected after an exogenous intake. The quantitative evaluation of active parent compounds like testosterone (which is actively involved in physiological processes of hair growth) in hair is still controversial. Clinical applications under reproducible conditions can be useful, but the biovariability of these parameters will probably prevent the definition of acceptable cut-off levels as a criterion of abuse.     

Contact shot from infantry weapons with a flash-suppressor

The number of reports on contact shots from firearms with a flash suppressor attached to the muzzle is small. On the basis of a case report (suicidal shot to the forehead with a Kalschnikow AKMS 47 assault rifle) the morphological peculiarities (characteristics soot pattern, relatively small powder cavity and only minor skin tears in the presence of a bony support) are presented and the conclusions to be drawn from the findings regarding the flash-suppressor, the shot distance, the angle of the shot and the way of holding the weapon are discussed.     

Sexualization and lifestyle impulsivity: clinically valid discriminators in sexual offenders

Following clinical observations in this study a comparison was undertaken between nonsexualized rapists, sexualized rapists, and pedophilic child molesters in terms of psychometric measures, criminological data, and DSM-IV diagnoses following the authors' hypotheses that nonsexualized and sexualized rapists differ in respect of psychiatric comorbidity and criminal history and sexualized rapists and pedophilic child molesters are more similar as regards to psychiatric comorbidity (anxiety, depression, and aggression) and criminal history variables than nonsexualized and sexualized rapists are. Preliminary findings confirmed the hypotheses: the authors found significant differences between paraphilic and sexualized sex offenders on one hand--regardless whether they had offended against minors or adults--and a group of sex offenders exhibiting a history of high lifestyle impulsivity on the other hand. From a psychiatric clinical point of view, paraphilic or sexualized rapists could be shown to resemble more the pedophilic child molesters. Therapeutic approaches should take these findings into account.