灌服毒鼠强诱导大鼠细胞DNA的损伤研究

目的研究毒鼠强体内染毒后,毒鼠强对大鼠脑细胞、心肌细胞、淋巴细胞DNA的损伤作用。方法选择健康Sprague-Dawley大白鼠20只,分成5组,每组4只,采用灌胃方法使大鼠毒鼠强体内染毒,按0.2,0.1,0.05,0.01mg·kg-1制作大鼠毒鼠强中毒模型,并以灌服生理盐水的健康大鼠为对照,分离实验大鼠的淋巴细胞、心肌细胞和脑细胞,用彗星电泳的方法测定不同浓度毒鼠强中毒后的细胞DNA损伤。结果0.2,0.1,0.05,0.01mg·kg-1剂量组的毒鼠强均可引起大鼠的淋巴细胞、心肌细胞和脑细胞DNA损伤,均与对照组差异有显著性(P<0.01)。结论毒鼠强诱导体内细胞DNA损伤可能是毒鼠强毒性作用机制之一。     

加快宁夏农业经济结构调整的思考

宁夏如何在WTO确定的农业政策空间内,面向国内外市场,调整农业结构,无疑是一个亟待研究和解决的问题.宁夏农业结构调整应从以下几方面进行:一、以国内外市场为导向,发展具有比较优势的特色农业和绿色食品产业.二、立足于资源优势,大力发展草业和畜牧业.三、突出重点,积极发展农产品加工业.     

Corporate Governance: Towards a Theory of Regulatory Shift

Providing effective corporate governance regulation and controls is a contemporary challenge to all law makers. There exists a need to restore investor confidence while seeking to facilitate and encourage enterprise. This paper reflects on the traditional choice between shareholder versus stakeholder models of corporate governance and suggests that these are inappropriate in the light of emerging news theories of the firm. Instead this paper suggests that law makers should accommodate a shift away from the traditional paradigms of these models in favour of a processual approach of governance. This would require a recognition of the tensions that exist in the regulation of corporate governance and invite the application of a collibratory process to the control of governance. The development and reform of directors’ duties and liabilities, in the UK, is provided as an illustration of the need for the recognised application of a collibratory process. Within that we also consider the application of the economists concept of ‘rent-seeking’ and the conflict between private property rights and public interference.JEL M14, D72, K22, K33     

为民众的学习“架桥铺路“

创建学习型城市,打破了旧的思维方式和思想观念的束缚,为大连注入了通向现代化、国际化的现代城市管理理念,成为推动大连创新发展的强大动力。为此,我们必须加快发展,夯实物质基础搞创建;重视教育,立足根本搞创建;倾听呼声,针对民众需求搞创建;加强调研,结合实际搞创建。     

农村公共品缺位思考——基于契约关系下公民平等权的分析

公民交纳税款的目的是使国家提供公共品,但这一契约关系下,中国长期以来实行的"城乡分治"二元经济结构,导致在城乡不同的地区,公共品的供给机制和能力存在天然的差别.显现出城市居民与农民之间享有权利不平等的现状,使农村公共品的缺住严重.倡导在公共服务体制下坚持公平优先,重构农村公共品的供给.     

Genetic data of 9 STR loci from Henan Province (central China)

Allele frequencies of the nine short tandem repeats (STR) loci D8S1179, D21S11, D18S51, D5S818, D3S1358, D7S820, vWA, FGA (AmpFlSTR Profiler Plus) were determined in a population sample of unrelated individuals living in central China.     

Analysis of 15 STR loci in Chinese population from Sichuan in West China

Allele frequencies for 15 STR loci found in PowerPlex 16 System kit were determined in a sample of 200 unrelated individuals living in Sichuan area in west China. The values of observed heterozygosity (Ho), power of discrimination (PD), probability of paternity exclusion (PE) and polymorphism information content (PIC) were calculated. All loci were in accordance with Hardy-Weinberg equilibrium (p<0.05). The obtained frequency distributions were compared with other previously reported population data.     

液相色谱-串联质谱法检测血液中的美西律

目的建立测定血液中美西律(mexiletine)的液相色谱-串联质谱联用法(LC-MS/MS)。方法采用简便的乙腈蛋白沉淀法对血液进行预处理,应用Allure PFP Propyl液相柱分离,用电喷雾正离子模式离子化,多反应监测模式对美西律进行分析。结果美西律与内标纳洛酮分离良好,在0.02～10.00μg/mL内线性关系良好,相关系数为0.9999,回归方程为y=0.0283x-0.0151,日内与日间精密度的RSD均小于15%,最低检测限为0.01μg/mL。结论建立的LC-MS/MS方法简单、灵敏、可靠,可同时适用于美西律临床药物监测和法医毒物分析的需要。     

不同死亡方式大鼠心肌组织中ATP、ADP和AMP含量比较

目的比较不同死亡方式对大鼠心肌组织能量物质变化的影响,为判断不同死亡方式及死亡时间提供依据。方法180只大鼠随机分为三组,以不同方式(失血、窒息、断颈)处死,高效液相色谱法检测死后0、0.5、1、1.5、2、3、4、6、8、12、18和24h大鼠心肌组织中的ATP、ADP、AMP含量。结果三组不同死亡方式大鼠心肌组织的ATP、ADP、AMP的含量在大部分时间点做组间比较有明显差异(P<0.05);每组不同死亡方式的大鼠心肌组织中ATP、AMP的含量随时间的变化有明显的差异(P<0.01),而各组中的ADP在死亡一定时间后无明显差异。结论不同死亡方式的大鼠心肌组织中能量物质死后变化可以用作对死亡方式及某种方式不同死亡时间做出判断的依据。     

论美国《统一商法典》的立法特点

美国《统一商法典》被誉为20世纪英美法系最为杰出的一部成文法典,其重要地位举世公认。然而,究竟是什么原因使得这部法典如此受世人青睐或瞩目?众所周知,《统一商法典》的起草人卡尔·卢埃林教授是美国现实主义法学运动的领军人物和主要代言人,有“头号现实主义者”之称,〔1〕