Anise oil as para-methoxyamphetamine (PMA) precursor

These days, MDMA is one of the most popular drugs of abuse. Due to its illegality, MDMA and its chemical precursors are watched by governmental organizations in many countries. To avoid conflicts with legal instances, underground chemists have tried to market several new unregulated amphetamine analogues, such as 4-MTA. Para-methoxyamphetamine (PMA), on the other hand, is regulated by law but its precursors are easily obtained since they are cheap and unwatched. This article presents such a case, namely the large scale synthesis of PMA using anethole, a main constituent of anise oil, as precursor. Anethole has been converted to its phenyl acetone analogue via peracid oxidation, while PMA itself has been synthesized using this ketone as precursor in the Leuckart synthesis. The synthesis of PMA using anethole as starting product has been investigated applying GC/MS and GC-HSPME/MS techniques, hereby discovering new specific (4-methoxyphenol) and already identified synthesis impurities (4-methyl-5-(4-methoxyphenyl)pyrimidine, N-(beta-4-methoxyphenylisopropyl)-4-methoxybenzyl methyl ketimine, 1-(4-methoxyphenyl)-N-(2-(4-methoxyphenyl)-1-methylethyl-2-propanamine, 1-(4-methoxyphenyl)-N-methyl-N-(2-(4-methoxyphenyl)-1-methylethyl-2-propanamine, N-(beta-4-methoxyphenylisopropyl)-4-methoxybenzaldimine). The new impurity 4-methoxyphenol is specific for the application of a peracid oxidation method where anethole is used as precursor.     

An unusual form of fatal ethanol intoxication

Forensic pathologists are very familiar with deaths due to ethanol intoxication. The overwhelming majority of these deaths are a result of the oral ingestion of ethanol. We report an unusual case of an individual who expired in his secured residence after self administration of a wine enema. Toxicology showed an ethanol concentration of 0.40 g/dL in the blood and 0.41 g/dL in the vitreous fluid. Scene investigation was of paramount importance in determining the unusual method by which the decedent absorbed the alcoholic beverage.     

New directions in social stratification and income distribution: Introduction

The contributors to this special issue address important problems in the area of social stratification and income distribution. More specifically, Van der Sar and Van Praag offer a solution to the problem of measuring the relative importance of a social position by referring to the individual utility function. Hermkens and Boerman test hypotheses derived from functionalist and marxist theory concerning the degree of value consensus associated with the differential allotment of income and prestige to social positions. Shepelak points to the effects of a prevailing system of norms and values — beliefs about meritocracy, fair shares and opportunity — on the equalization of incomes. Arts and Van Wijck study social constraints to income equalization and focus on the inadequacy of decision-making processes and imperfect implementation of decisions. In the final contribution to this issue, Jasso examines the behavioral and social consequences of the simultaneous operation of two distinct considerations on courses of action: the individual's own well-being and the societal common good.