Voting on slavery at the Constitutional Convention

This paper provides the first empirical study of delegate voting behavior on issues of slavery at the U.S. Constitutional Convention. We analyze two categories of votes: those related to apportionment and those related to the regulation of the slave trade. Although it is widely believed that delegates voted consistent with the interests of their states on issues of slavery, we find that for votes on apportionment, the effect of state interests was enhanced by both the delegate’s personal interest and his religious background. For votes regulating the slave trade, state interests had a significant effect but only within specific regions.     

Three conditions under which experiments and observational studies produce comparable causal estimates: New findings from within‐study comparisons

This paper analyzes 12 recent within‐study comparisons contrasting causal estimates from a randomized experiment with those from an observational study sharing the same treatment group. The aim is to test whether different causal estimates result when a counterfactual group is formed, either with or without random assignment, and when statistical adjustments for selection are made in the group from which random assignment is absent. We identify three studies comparing experiments and regression‐discontinuity (RD) studies. They produce quite comparable causal estimates at points around the RD cutoff. We identify three other studies where the quasi‐experiment involves careful intact group matching on the pretest. Despite the logical possibility of hidden bias in this instance, all three cases also reproduce their experimental estimates, especially if the match is geographically local. We then identify two studies where the treatment and nonrandomized comparison groups manifestly differ at pretest but where the selection process into treatment is completely or very plausibly known. Here too, experimental results are recreated. Two of the remaining studies result in correspondent experimental and nonexperimental results under some circumstances but not others, while two others produce different experimental and nonexperimental estimates, though in each case the observational study was poorly designed and analyzed. Such evidence is more promising than what was achieved in past within‐study comparisons, most involving job training. Reasons for this difference are discussed. © 2008 by the Association for Public Policy Analysis and Management.     

The Forgotten Prophet: Tom Paine's Cosmopolitanism and International Relations

The recent questions about the viability of political realism highlight a need for alternative theoretical frameworks to guide international relations research. These alternatives, however, have been slow to emerge, due in part to the field's traditional neglect of political theory. In this essay I present an alternative based on a survey of Paine's international thought. Sir Michael Howard referred to Paine as the most important internationalist writer of all time, but his contributions have been largely ignored by students of international relations. Paine was a classic second image theorist who first posited how democratic governance would promote a peaceful world. Paine's works leave us with all the features of cosmopolitan thinking in international relations: Faith in reason and progress, the evils of authoritarian regimes, the democratic peace, the peaceful effect of trade, nonprovocative defense policies, open diplomacy, obsolescence of conquest, the universal respect for human rights, and the democratic propensity to engage in messianic interventionism. I conclude with a comparison of Kant and Paine where I argue that Paine is the more faithful representative of the Enlightenment for students of international relations.     

China's Future Economic Regionalization

This paper investigates China's economic growth potentials and limitation up to 2020 and recommends a trend of economic regionalization. A sustainable growing economy is a necessity for China's future stability. The growth sustainability of the Chinese economy depends essentially on its continued commitments to institutional reform and economic deregulation. China's relaxation of government intervention in economic activities has led and will be leading China to decentralize its central governmental authority over economic planning and control. This will consequently stimulate the emergence of regional economies in Mainland China. In the next two decades, there will likely be 10 regional economies with relatively independent industrial structures emerging in Greater China (or the Chinese Economic Area of Hong Kong, Macao, Taiwan and the Mainland) as a result of economic liberalization and decentralization.     

The histopathological spectrum of myocardial inflammation in relation to circumstance of death: a retrospective cohort study in clinical and forensic autopsies

Interpreting a myocardial inflammation as causal, contributory or as of no significance at all in the cause of death can be challenging, especially in cases where other pathologic and/or medico-legal findings are also present. To further evaluate the significance of myocardial inflammation as a cause of death we performed a retrospective cohort study of forensic and clinical autopsy cases. We revised the spectrum of histological inflammatory parameters in the myocardium of 79 adult autopsy cases and related these to the reported cause of death. Myocardial slides were reviewed for the distribution and intensity of inflammatory cell infiltrations, the predominant inflammatory cell type, and the presence of inflammation-associated myocyte injury, fibrosis, edema and hemorrhage. Next, the cases were divided over three groups, based on the reported cause of death. Group 1 (n = 27) consisted of all individuals with an obvious unnatural cause of death. Group 2 (n = 29) included all individuals in which myocarditis was interpreted to be one out of more possible causes of death. Group 3 (n = 23) consisted of all individuals in which myocarditis was reported to be the only significant finding at autopsy, and no other cause of death was found. Systematic application of our histological parameters showed that only a diffuse increase of inflammatory cells could discriminate between an incidental presence of inflammation (Group 1) or a potentially significant one (Groups 2 and 3). No other histological parameter showed significant differences between the groups. Our results suggest that generally used histological parameters are often insufficient to differentiate an incidental myocarditis from a (potentially) significant one.     

A retrospective study of drugged driving in Norway

The National Institute of Forensic Toxicology, Oslo, receives blood and urine samples from all Norwegian drivers apprehended on suspicion of driving under the influence of alcohol or drugs. In 1983 we received samples from 1446 drug-suspected drivers, out of which 445 underwent toxicological analysis. The drugs found most frequently were tetrahydrocannabinol (THC) (n = 199), diazepam (n = 166) and amphetamine (n = 102). A cautious interpretation of the data indicate that about 200 of the 445 subjects selected for toxicological analysis drove under severe influence of drugs. Because of the high percentage of submitted cases not analysed for drugs, this figure represents a minimum estimate. Compared with the results from 1978, we found a several-fold increase in detections of THC and amphetamine in 1983. The number of diazepam detections did not increase in a similar way, but we estimated that the diazepam detections would have increased 3-fold if we had analysed as frequent for this drug in 1983 as in 1978.     

Fatal motorcycle accidents and alcohol

A series of fatal motorcycle accidents from a 7-year period (1977-1983) has been analyzed. Of the fatalities 30 were operators of the motorcycle, 11 pillion passengers and 8 counterparts. Of 41 operators 37% were sober at the time of accident, 66% had measurable blood alcohol concentration (BAC); 59% above 0.08%. In all cases where a pillion passenger was killed, the operator of the motorcycle had a BAC greater than 0.08%. Of the killed counterparts 2 were non-intoxicated, 2 had a BAC greater than 0.08%, and 4 were not tested. The results advocate that the law should restrict alcohol consumption by pillion passengers as well as by the motorcycle operator. Suggestions made to extend the data base needed for developing appropriate alcohol countermeasures by collecting sociodemographic data on drivers killed or seriously injured should be supported.     

Study of cathepsin A, B and D activities in the skin wound edges. Its application to the differential diagnosis between vital and postmortem wounds

The aims of the authors in this paper has been to check the diagnostic ability of the Cathepsin A, B and D concentrations in the skin wound edges to the differential diagnosis between vital and postmortem wounds. We have studied 56 domestic pigs grouped in seven experimental series consisting of 8 animals in each, according to the time (0, 5, 15, 30 min and 1, 3 and 6 h) after the injury. The enzymatic activities were investigated following the methods by Bowen and Davison Biochem. J., 131 (1973) 417-419, Suhar and Marks J. Biochem., 101 (1979) 23-30 and by Anson (modified by Yamamoto, Eur. J. Biochem., 95 (1979) 459-467) for Cathepsin A, B and D, respectively. For the differential diagnosis between vital and postmortem wounds, our results showed that the most useful markers studied are the Cathepsin A and D activities, Cathepsin D that of the first one.