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141.
The English Patents Court has recently refused a declarationof non-infringement in relation to the compound patent coveringAtorvastatin (Lipitor), the world's best-selling drug, but founda patent relating to its hemicalcium salt invalid for lack ofnovelty and obviousness; this decision is seen as a victoryfor Pfizer since the invalidation of the hemicalcium salt patenthas not shortened its period of exclusivity. 相似文献
142.
The application of infrared chemical imaging to the analysis of bicomponent fibers was evaluated. Eleven nominally bicomponent fibers were examined either side-on or in cross-section. In six of the 11 samples, infrared chemical imaging was able to spatially resolve two spectroscopically distinct regions when the fibers were examined side-on. As well as yielding characteristic infrared spectra of each component, the technique also provided images that clearly illustrated the side-by-side configuration of these components in the fiber. In one case it was possible to prepare and image a cross-section of the fiber, but in general the preparation of fiber cross-sections proved very difficult. In five of the 11 samples, the infrared spectra could be used to identify the overall chemical composition of the fibers, according to a published classification scheme, but the fiber components could not be spatially resolved. Difficulties that are inherent to conventional "single-point" infrared spectroscopy, such as interference fringing and sloping baselines, particularly when analyzing acrylic type fibers, were also encountered in the infrared chemical image analysis of bicomponent fibers. A number of infrared sampling techniques were investigated to overcome these problems, and recommendations for the best sampling technique are given. Chemical imaging results were compared with those obtained using conventional fiber microscopy techniques. 相似文献
143.
Eckenrode BA Ramsey SA Stockham RA Van Berkel GJ Asano KG Wolf DA 《Journal of forensic sciences》2006,51(4):780-789
The Scent Transfer Unit (STU-100) is a portable vacuum that uses airflow through a sterile gauze pad to capture a volatiles profile over evidentiary items for subsequent canine presentation to assist law enforcement personnel. This device was evaluated to determine its ability to trap and release organic compounds at ambient temperature under controlled laboratory conditions. Gas chromatography-mass spectrometry (GC-MS) analyses using a five-component volatiles mixture in methanol injected directly into a capture pad indicated that compound release could be detected initially and 3 days after the time of collection. Additionally, 15 compounds of a 39-component toxic organic gaseous mixture (10-1000 parts per billion by volume [p.p.b.(v)]) were trapped, released, and detected in the headspace of a volatiles capture pad after being exposed to this mixture using the STU-100 with analysis via GC-MS. Component release efficiencies at ambient temperature varied with the analyte; however, typical values of c. 10% were obtained. Desorption at elevated temperatures of reported human odor/scent chemicals and colognes trapped by the STU-100 pads was measured and indicated that the STU-100 has a significant trapping efficiency at ambient temperature. Multivariate statistical analysis of subsequent mass spectral patterns was also performed. 相似文献
144.
145.
Political participation researchers have developed several evaluative techniques to assess the representativeness of political participation patterns. Yet, while the Internet has become a mainstream avenue for political participation in the United States, current assessments of online participation insufficiently apply these methods. To incorporate these methods we begin by drawing upon resource theory to inform two-stage ordered-logit models of online and offline political participation. Our results suggest that the factors predicting online participation often differ from the factors that predict offline participation. Even so, we find that those from higher socioeconomic backgrounds tend to disproportionately possess these distinct online determinants. Next, we use a wide spectrum of political opinion questions to determine whether online participators opinions reflect or distort those of the general population. Overall, we find that online participation tends to relate moderately with liberal preferences. However, because offline participation relates to political attitudes similarly, the Internet only marginally advantages the political voice of liberals. Finally, we discuss the implications of these results. 相似文献
146.
Marx BP 《Journal of interpersonal violence》2005,20(2):225-230
The present article attempts to answer important questions about the most important thing learned from the past 20 years of research on sexual violence, the most important thing to be learned about sexual violence over the next 10 years, and the most promising methodological innovation in the study of sexual violence from the last 20 years. It is hoped that discussion of such important questions might further stimulate researchers and mental health professionals to continue making progress in our understanding of, as well as the struggle against, sexual violence. 相似文献
147.
Mental health review bodies engage in complex decision-making that may explicitly incorporate a therapeutic philosophy. Examination of select decisions of the New Zealand Mental Health Review Tribunal offers a foundation for understanding some implications of a pro-therapeutic approach. This analysis draws upon therapeutic jurisprudence scholarship in relation to three aspects of the hearings as documented in the written decisions: advocacy, therapeutic intervention, and the dignitary potential of the proceedings. The research explores the unintended consequences of a pro-therapeutic approach and evaluates the potential application of therapeutic jurisprudence within a mental health law context. 相似文献
148.
Jason C. Coronel Melissa C. Duff David E. Warren Kara D. Federmeier Brian D. Gonsalves Daniel Tranel Neal J. Cohen 《American journal of political science》2012,56(4):837-848
One of the most prominent claims to emerge from the field of public opinion is that citizens can vote for candidates whose issue positions best reflect their own beliefs even when they cannot remember previously learned stances associated with the candidates. The current experiment provides a unique and powerful examination of this claim by determining whether individuals with profound amnesia, whose severe memory impairments prevent them from remembering specific issue information associated with any particular candidate, can vote for candidates whose issue positions come closest to their own political views. We report here that amnesic patients, despite not being able to remember any issue information, consistently voted for candidates with favored political positions. Thus, sound voting decisions do not require recall or recognition of previously learned associations between candidates and their issue positions. This result supports a multiple memory systems model of political decision making. 相似文献
149.
150.
Brian Cooksey 《Crime, Law and Social Change》2012,58(5):521-531
If the OECD??s Development Co-operation Report for 2009 is correct in its claim that ??The international aid effort now adds up to less than the sum of its parts??, then continued rapid growth in aid transfers is likely to contribute to further aid absorption problems, as well as institutional atrophy and deteriorating governance and corruption control among aid recipients. This article considers aid for good governance and anti-corruption, using Tanzania as an example. ??The supply side of aid?? sketches the bigger picture in which such aid is located, stressing collective action problems facing the aid industry in the current period of growth and diversification. ??The consequences of aid proliferation on corruption control in an aid-dependent state?? provides some empirics from Tanzania. ??Conclusions: whither ??corruption control????? draws some conclusions for the future of aid for governance and corruption control. A key message is that donor-driven governance and corruption control initiatives have failed to address the governance weaknesses that excessive and uncoordinated aid has helped to create. 相似文献