Eosinophilic Coronary Periarteritis with Arterial Dissection: The Mast Cell Hypothesis

A subset of coronary arterial dissections is associated with eosinophilic coronary periarteritis (ECPA); however, the pathogenesis of the process remains unclear. Mast cells normally reside in coronary arterial adventitia and are known mediators of eosinophilic inflammatory conditions such as type I hypersensitivity reactions. We report two cases in which coronary arterial dissection with ECPA was detected at autopsy. Tryptase, CD68, CD4, CD8, and CD1a immunohistochemical staining was performed to better characterize inflammation. While eosinophils represented a prominent periadventitial inflammatory cell, there were slightly more lymphocytes: CD4/CD8 ratios were within expected reference ranges. There were moderate numbers of macrophages, and few neutrophils or dendritic cells. Numbers of mast cells in dissected versus nondissected sections were compared: adventitial mast cell densities were threefold higher in dissected portions and showed a trend toward increased degranulation. These findings suggest that mast cells may play a role in orchestrating inflammation in cases of ECPA.     

Silicosis: Diagnosis and Medicolegal Implications

Despite well‐publicized sources of occupational hazard, silicosis continues to threaten industrial workers in the United States. We performed a retrospective search of the University of Wisconsin electronic pathology database to retrieve autopsy cases of silicosis and collaborated with the Wisconsin Department of Health Services to obtain statewide epidemiologic data regarding silicosis morbidity/mortality since 2003. Three silicosis autopsy cases were retrieved: all were men with ≥ 30 years of occupational crystalline silica exposure and similar histologic features of collagenous pulmonary nodules with admixed refractile particles. Overall, our state exceeds the national rate of silicosis‐related hospitalizations and mortality, that is, 10.1 hospitalizations per million WI residents versus 1.2 nationally and 1.2 deaths per million WI residents versus 0.4 nationally. Surveillance is crucial to identify emerging occupational hazards and protect workers. A diagnosis of silicosis must be carefully considered at autopsy since it carries substantial implications for worker's compensation, compensatory losses, and employer liability.     

Postmortem genetic testing in sudden unexplained death: A public health laboratory experience

Sudden unexplained death in the young poses a diagnostically challenging situation for practicing autopsy pathologists, especially in the absence of anatomic and toxicological findings. Postmortem genetic testing may identify pathogenic variants in the deceased of such cases, including those associated with arrhythmogenic channelopathies and cardiomyopathies. The Wisconsin State Laboratory of Hygiene (WSLH) is a state-run public health laboratory which performs postmortem genetic testing at no cost to Wisconsin medical examiners and coroners. The current study examines sequencing data from 18 deceased patients (ages 2 months to 49 years, 5 females) submitted to WSLH, from 2016 to 2021. Panel-based analysis was performed on 10 cases, and whole exome sequencing was performed on the most recent 8 cases. Genetic variants were identified in 14 of 18 decedents (77.8%), including 7 with pathogenic or likely pathogenic variants (38.9%). Whole exome sequencing was more likely to yield a positive result, more variants per decedent, and a larger number of variants of uncertain significance. While panel-based testing may offer definitive pathogenic variants in some cases, less frequent variants may be excluded. Whole exome testing may identify rare variants missed by panels, but increased yield of variants of uncertain significance may be difficult to interpret. Postmortem genetic testing in young decedents of sudden unexplained death can provide invaluable information to autopsy pathologists to establish accurate cause and manner of death and to decedent's relatives to allow appropriate management. A public health laboratory model may be a financially advisable alternative to commercial laboratories for medical examiner's/coroner's offices.     

Management by Inquiry: A Discursive Accountability System for Large Organizations

Over the past decade, American police departments have developed a new management methodology that is beginning to be adopted by agencies outside law enforcement. Although the technique has been given different names by different agencies, this article refers to it generically as "management by inquiry" because the approach uses frequent, highly formalized meetings of top executives, middle management, and line personnel to inquire into the operations of individual units. The authors have had five years of direct experience with management by inquiry and have observed it in other jurisdictions. The present analysis draws on Habermas's theory of communicative action to contrast the communication premises in much management theory and practice with those implicit in inquiry-centered management. The article concludes that management by inquiry has dramatic effects on administrative behavior because it takes advantage of universal communicative norms that public administration has long overlooked.     

The Brazilian Landless Movement,Resistance, and Violence

Throughout Brazil, landless resisters are being violently victimized at the discretion of large landowners. The main goals of this article are to (1) Explain the historical and current conditions that have facilitated the violent oppression experienced by the landless movement, (2) illustrate the mass violence experienced by the landless population, (3) provide a review of the existing research regarding the relationship between land reform, violence, and state strength, (4) introduce a new explanation of decentralized state power in relationship to the persistence of violence against the landless movement. I explore the Brazilian landless movement through content analyses, fieldwork, and a review of existing data. The approach used to study and understand the powers associated with the landless movement is unique to the existing literature of the Brazilian landless movement in that it moves beyond advocacy towards a criminological and political analysis.     

Population data for a novel, highly discriminating tetra-local Y-chromosome short tandem repeat: DYS503

Population: Population samples for gene diversity studies were obtained from the Virginia Division of Forensic Science (bloodstains), Richmond, VA. Ninety-eight Caucasian and 100 African American samples were included in this study.     

Body Dissatisfaction,Living Away from Parents,and Poor Social Adjustment Predict Binge Eating Symptoms in Young Women Making the Transition to University

The current study explored how body dissatisfaction and challenges associated with the transition to university predicted symptoms of binge eating. Participants were 101 female full-time first-year university students (M=18.3 years of age; SD=.50) who completed a background questionnaire and a web-based daily checklist assessing binge eating. Hierarchical Generalized Linear Modeling results showed that participants who were more dissatisfied with their bodies were three times as likely to report symptoms of binge eating compared to participants who were less dissatisfied. Participants who lived away from home were three times as likely to report symptoms of binge eating compared to participants living with parents. Finally, poor perceived social adjustment to the university context was associated with an increased likelihood of binge eating. Discussion calls for more research exploring the role that university challenges and adjustment play in predicting eating problems.

‘The Cooling of Hearts’: Community Truth-Telling in Northern Uganda

Recent national and international debates on truth and reconciliation in Uganda have emphasized the importance of incorporating local-level mechanisms into a national transitional justice strategy. The Juba Peace Talks represented an opportunity to develop and articulate sufficient and just alternatives and complementary mechanisms to the international criminal model. The most commonly debated mechanism is the Acholi process known as mato oput (drinking the bitter root), a restorative justice approach to murder. Drawing on 2 months of research in nine internally displaced persons’ camps in 2007, we examine local justice practices in the region of northern Uganda to consider their potential, promise and pitfalls to realizing a successful truth-telling process. We find that although local mechanisms could help facilitate reconciliation in the region, truth-telling is but one part of a conciliatory process complicated by a national context of fear and the complexity of the victim–perpetrator identity at the community level. These locally informed insights help move forward the debate on such mechanisms in Uganda and add useful insights into community processes in the field of transitional justice more generally.     

Performance evaluation and optimization of multiplex PCRs for the highly discriminating OSU 10-locus set Y-STRs

In a previous study, a new set of Y-chromosome short tandem repeats, the OSU 10-locus set (MPM1 and MPM2), was shown to have a higher discrimination power when evaluated against the 10 SWGDAM loci on a common population panel. Here, we describe the optimization of the multiplex reactions using dye-labeled primers followed by performance evaluations. The loci exhibited high precision, human male specificity, reliability in different body fluids, high sensitivity, stability, and the ability to amplify nonprobative casework and mixture samples. Stutter for the all of the loci, with the exception of the highly polymorphic locus DYS688, was similar to that observed for autosomal loci. The results of the performance evaluations reinforced the utility of these loci.