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Doping control laboratories accredited by the World Anti-Doping Agency (WADA) require criteria that allow endogenous steroids to be distinguished from their synthetic analogues in urine. Methodology based on "looking outside the metabolic box" was used in this study to identify diagnostic urinary markers of 4-androstenediol (4-ADIOL) administration. Androst-2,4-diene-17-one and androst-3,5-diene-17-one are proposed to be formed in urine from acid-catalyzed hydrolysis of 4-ADIOL sulfoconjugate, a major phase II metabolic product of 4-ADIOL. The presence of these markers in the routine gas chromatography-mass spectrometry (GC-MS) steroid screen was suitable to identify samples requiring confirmation by gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) - to measure the carbon isotope ratio (δ(13)C) of the androstdiene markers and confirm their likely synthetic origin based on depleted (13)C content. 相似文献
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Infants, parental separation, custody, and overnight care: a vexed combination of issues and needs that has long perplexed the family law field. Carol George and Judith Solomon have conducted the only published observational study of infant attachment in light of postseparation overnight care arrangements. Here they revisit that study and bring more than three decades of experience to bear on questions concerning very young children implicated in family law disputes. Currently a professor of psychology at Mills College, California, George is an author and coauthor of several notable attachment measures and has over 50 research publications in the area of attachment. Judith Solomon is both a clinical psychologist and a researcher in the attachment field, specializing in the study of early attachment relationships and representations, most recently in the Department of Pediatrics, Bridgeport Hospital. George and Solomon are associate editors of the journal, Attachment and Human Development, reviewers on multiple developmental journals, and both consult and teach internationally. 相似文献
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Concerns about domestic energy security and global climate change mitigation have led the European Union, the United States, and others to introduce policies to enhance the use of biofuels in the transport sector fuel mix. While countries throughout the global South are positioning themselves to capture the economic benefits of this fuel transition, their capacity to do so is highly variable. This paper reviews the early evolution of the biofuel sector in Zambia to explore the extent to which the country is positioned to leverage future benefits of the emerging industry while forestalling negative social and environmental costs. In doing so, it sheds light on an under‐researched dimension of the ongoing debate over large‐scale land acquisitions and foreign investment: the role of legal and institutional frameworks in host countries in shaping outcomes. The analysis draws on the following: policy documents; stakeholder interviews with government departments, investors, and civil society stakeholders; and published and reported data on investments. Findings suggest that while existing and incipient policies and legislation provide an important foundation for attracting investors and achieving diverse sector aims, a number of gaps remain that are likely to hinder efforts to leverage meaningful benefits while minimizing negative impacts. 相似文献
347.
In Romania, the quantification of traumatic injuries is achieved in medical- legal services; therefore, each domestic violence (DV) victim needs a medical-legal certificate to prove in a court of law the presence of traumatic injuries. In this study, we aimed to determine the pattern of traumatic injuries in DV. A total of 219 consecutive DV cases were included. For each victim, a detailed medical-legal examination was performed, including specialized consults, if needed. Results were analyzed statistically using the SPSS software. Traumatic injuries in DV cases were usually located in the head, face, and neck areas and had a low severity index. Severe lesions were found in less than 10% and no sexual aggression was found. The severity increases with age and is higher for males than females. The pattern of DV-associated injuries we have encountered is similar to the one found in other similar studies. Knowing this pattern may be useful in clinical practice to detect cases of DV. 相似文献
348.
Simpson DD Joe GW Knight K Rowan-Szal GA Gray JS 《Journal of offender rehabilitation》2012,51(1-2):34-56
The TCU Short Forms contain a revised and expanded set of assessments for planning and managing addiction treatment services. They are formatted as brief (1-page) forms to measure client needs and functioning, including drug use severity and history (TCUDS II), criminal thinking and cognitive orientation (CTSForm), motivation and readiness for treatment (MOTForm), psychological functioning (PSYForm), social relations and functioning (SOCForm), and therapeutic participation and engagement (ENGForm). These instruments facilitate optically-scanned data entry, computerized scoring, and rapid graphical feedback for clinical decisions. The present study (based on 5,022 inmates from eight residential prison treatment programs) examines evidence on scale reliabilities and measurement structures of these tools. Results confirmed their integrity and usefulness as indicators of individual and group-level therapeutic dynamics. 相似文献
349.
Joe GW Knight K Simpson DD Flynn PM Morey JT Bartholomew NG Tindall MS Burdon WM Hall EA Martin SS O'Connell DJ 《Journal of offender rehabilitation》2012,51(1-2):9-33
Finding brief effective treatments for criminal justice populations is a major public need. The CJ-DATS Targeted Intervention for Corrections (TIC), which consists of six brief interventions (Communication, Anger, Motivation, Criminal Thinking, Social Networks, and HIV/Sexual Health), were tested in separate federally-funded randomized control studies. In total, 1,573 criminal justice-involved individuals from 20 correction facilities participated (78% males; 54% white). Multi-level repeated measures analyses found significant gains in knowledge, attitudes, and psychosocial functioning (criteria basic to Knowledge, Attitude, and Practices (KAP) and TCU Treatment Process Models). While improvements were less consistent in criminal thinking, overall evidence supported efficacy for the TIC interventions. 相似文献
350.
This research examined job satisfaction among members (N?=?1,057) of the American Society of Criminology (ASC) and the Academy of Criminal justice Sciences (ACJS). In particular, the research looked at what factors are related to job satisfaction (enjoyment). We explored substantive personal and professional correlates such as stress, family life, and scholarly productivity. A host of demographic factors including gender, race and income, were also included in the analysis. The multivariate analysis revealed that those criminologists with more journal article publications, and devote more time to family and friends, had high job satisfaction. Conversely, criminologists living in the south had low job satisfaction compared to those living in other parts of the country. The paper ends with a call for the continuing exploration of the personal and professional correlates of job satisfaction among criminologists. 相似文献