The extent of postmortem drug redistribution in a rat model.

The aim of this study was to investigate the postmortem redistribution of several drugs in a rat model and to examine if any of the pharmacological properties was related to the extent of this phenomenon. One of the following drugs: phenobarbital (phenobarbitone), acetaminophen (paracetamol), carbamazepine, codeine, verapamil, amphetamine, mianserin, trimeprazine (alimemazine) or chloroquine was administered together with nortriptyline orally to rats 90 min prior to sacrifice. Heart blood was sampled immediately before sacrifice and after 2 h postmortem, as it has previously been shown that this is sufficient time for postmortem concentration changes to occur in heart blood. Blood was also sampled from the clamped abdominal inferior vena cava (representing peripheral blood) and tissue samples were taken from lungs, myocardium, liver, kidney, thigh muscle, forebrain, and vitreous humor together with a specimen from the minced carcass. Drugs were analyzed by high performance liquid or gas chromatography. For phenobarbital, acetaminophen and carbamazepine the postmortem to antemortem blood drug concentration ratios were close to 1.0 and tissue concentrations were low. The postmortem to antemortem heart blood drug concentration ratio for chloroquine (6.9 +/- 1.5) was higher than for nortriptyline (3.5 +/- 0.3), and the remaining drugs (codeine, verapamil, amphetamine, mianserin, and trimeprazine) showed ratios of the same magnitude as nortriptyline. The postmortem to antemortem blood drug concentration ratios for both heart blood and blood from the vena cava and also the lung to antemortem blood drug concentration ratio were closely related to the apparent volume of distribution for the drugs studied (p < 0.001). Accordingly, an apparent volume of distribution of more than 3-4 L/kg is a good predictor that a drug is liable to undergo postmortem redistribution with significant increments in blood levels. The postmortem drug concentration in blood from vena cava was closely related to the antemortem blood level, confirming that among the postmortem samples, the peripheral blood sample was the most representative for the antemortem blood concentration.     

Microscopic examination of Guaraná powder--Paullinia cupana Kunth]

Guaraná is a product from the seeds of the Amazonian liana Paullinia cupana that is also cultivated since a couple of years. It is rich in caffeine and serves in Brasil for the production of stimulants, soft drinks, and sweets. In the drug scene it is sometimes trafficked as natural stimulant or drug surrogate. Microscopic examination shows the presence of starch and tannins and provides a simple, quick and cheap method to distinguish guaraná from drugs of abuse.     

Protective Orders and Domestic Violence: Risk Factors for Re-Abuse

One of the few legal tools for protecting victims of domestic violence is the civil Protection Order (PO). How effective they were in preventing re-abuse was analyzed by examining court and police records from 210 couples in which female victims (or applicants) filed POs against their violent partners. Police records for 2 years prior and two years following the issuance of a PO were reviewed. Results indicated a significant decline in the probability of abuse following a PO. Prior to filing a PO, 68% of the women reported physical violence. After filing, only 23% reported physical violence. Several risk factors were assessed and it was found that very low SES women were more likely to report re-abuse as were African-Americans.     

Airport Security, High Reliability, and the Problem of Rationality

The events of September 11, 2001, have raised troubling questions regarding the reliability and security of American commercial air travel. This article applies the concepts and logic of high–reliability organizations to airport security operations. Contemporary decision theory is built on the logic of limited or buffered rationability and is based on the study of error–tolerant organizations. The concept of high–reliability organizations is based on the study of nearly error–free operations. For commercial air travel to be highly secure, there must be very high levels of technical competence and sustained performance; regular training; structure redundancy; collegial, decentralized authority patterns; processes that reward error discovery and correction; adequate and reliable funding; high mission valence; reliable and timely information; and protection from external interference in operations. These concepts are used to inform early–stage issues being faced by both local airports and the newly established Transportation Security Administration.     

Das Thermo-Hygro-Labyrinth Ein neues Ger?t zur gleichzeitigen Ermittlung von Vorzugstemperatur und Vorzugsluftfeuchtigkeit bei Arthropoden

Zusammenfassung Vorzugstemperatur und Vorzugsluftfeuchtigkeit konnten bisher nur getrennt ermittelt werden, so da? zusammenh?ngende Pr?ferenz?nderungen zwischen Vorzugstemperatur und Vorzugsluftfeuchtigkeit nicht erfa?bar waren. Mit Hilfe einer neuen Apparatur, dem Thermo-Hygro-Labyrinth, wurde es m?glich, Vorzugstemperatur und Vorzugsluftfeuchtigkeit gleichzeitig zu bestimmen. Das neue Ger?t besteht aus einem “Labyrinth” von Kammern mit unterschiedlichen Temperaturen und Luftfeuchtigkeiten. Sie sind durch Laufr?hren miteinander verbunden, so da? die Versuchstiere jede beliebige Kammer aufsuchen k?nnen. Die Kammern sind in fünf parallelen L?ngsreihen mit je sieben Kammern angeordnet. Jede Reihe weist die gleiche Temperatur auf. Es k?nnen somit insgesamt fünf Temperaturstufen eingestellt werden. Rechtwinklig zur L?ngsrichtung gesehen weist jede der sieben Querreihen mit ihren fünf Kammern die gleiche Luftfeuchtigkeit auf. Dabei kann von Querreihe zu Querreihe die Luftfeuchtigkeit stufenweise steigen. Es stehen also maximal sieben Feuchtigkeitsstufen zur Verfügung. Zur Regulierung der Lufttemperatur in den Kammern steht jede Kammerl?ngsreihe in einem separat temperierbaren Wasserbecken. Die verschiedenen Luftfeuchtigkeiten werden durch ges?ttigte Salzl?sungen bewirkt.

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Summary For technical reasons it was not possible until now to study temperature and humidity preferences of arthropods simultaneously. It was therefore impossible to examine the influence of both preferences on each other. A new apparatus, the Thermo-Hygro-Labyrinth, permits the simultaneous investigation of preferred temperature and humidity. It consists of a “labyrinth” of chambers with different temperatures and humidities. They are connected by tubes (Fig. 1, “Verbindungsgang”) so that the insect can reach every chamber. The chambers are arranged in five parallel longitudinal lines, each line consisting of seven chambers showing the same temperature. Altogether there are five different temperatures. At a right angle to the longitudinal lines each of the seven cross lines consists of five chambers with the same humidity, so that seven humidity steps can be arranged. To control the air temperature in the chambers each longitudinal chamber line is surrounded by a separate temperature-regulated water bath (Fig. 2, “inneres Becken”). These five smaller water bathes are arranged in a larger one (“?u?eres Becken”). The arrangement works as a cooling system to provide temperatures below room temperatures. The humidity of each chamber is regulated by saturated salt solutions (Fig. 3) located under a perforated run floor (Fig. 2, “Laufboden”). Triangle prisms fill in all corners of the chambers and prevent the animal from hiding instead of looking for another chamber offering more favourable temperature or humidity conditions.

     

Reviews

Harry Eckstein, Frederic J. Fleron, Erik P. Hoffmann & William M. Reisinger with Richard Ahl, Russell Bova & Philip G. Roeder, Can Democracy Take Root in Post‐Soviet Russia? Explorations in State‐Society Relations. Lanham: Rowan & Littlefield Publishers, 1998, xi + 418 pp., $64.00 h/b, $21.95 p/b.

Barnett R. Rubin & Jack Snyder (eds), Post‐Soviet Political Order. Conflict and State Building, London: Routledge, 1998, xi + 201 pp., £15.99.

Ben Fowkes (ed.), Russia and Chechnia: The Permanent Crisis. Essays on Russo‐Chechen Relations. Basingstoke: Macmillan, 1998, viii+ 188 pp., £42.50.

Anatol Lieven, Chechnya: Tombstone of Russian Power. London: Yale University Press, 1998, xii + 436 pp., £25.00.

Sebastian Smith, Allah's Mountains: Politics and War in the Russian Caucasus. London: I. B. Tauris, 1998, x + 288 pp., £19.95.

Taras Kuzio, Ukraine: Nation and State Building. London: Routledge, 1998, xiv + 298 pp., £50.00.

Lutz Hoffmann & Axel Siedenberg (eds), Aufbruch in die Marktwirtschaft. Reformen in der Ukraine von innen betrachtet. Frankfurt/New York: Campus Verlag, 1997, 296 pp.

OECD, OECD Economic Surveys. Russian Federation 1997. Paris: Centre for Co‐operation with the Economies in Transition and OECD, 1997, x + 275 pp.

Arista Maria Cirtautas, The Polish Solidarity Movement. Revolution, Democracy and Natural Rights. London: Routledge, 1997, xii + 324 pp., £50.00.

David Stark & Laszlo Bruszt, Postsocialist Pathways: Transforming Politics and Property in East Central Europe. Cambridge: Cambridge University Press, 1998, xi + 284 pp., £15.95.

Jon Elster, Claus Offe & Ulrich K. Preuss with Frank Boenker, Ulrike Goetting & Friedbert W. Rueb, Institutional Design in Post‐Communist Societies, Rebuilding the Ship at Sea. Cambridge: Cambridge University Press, 1998, xii + 350 pp., £14.95.

Daniel Vaughan‐Whitehead (ed.), Paying the Price. The Wage Crisis in Central and Eastern Europe. Basingstoke: Macmillan, 1998, xxviii + 418 pp., £55.00.

David Clapham, József Hegedüs, Keith Kintrea & Iván Tosics with Helen Kay (eds), Housing Privatization in Eastern Europe. London: Greenwood Press, 1996, xiii + 205 pp., £42.50.

Fergus Carr (ed.), Europe: The Cold Divide. Basingstoke: Macmillan, 1998, xii + 208 pp., £42.50.

Ian Anthony (ed.), Russia and the Arms Trade. Oxford, Oxford University Press and Stockholm International Peace Research Institute, 1998, xiv + 304 pp., £35.00.

Hannes Adomeit, Imperial Overstretch: Germany in Soviet Policy from Stalin to Gorbachev. Baden‐Baden: Nomos, 609 pp., DM69.00.

Yongjin Zhang & Rouben Azizian (eds), Ethnic Challenges Beyond Borders: Chinese and Russian Perspectives of the Central Asian Conundrum. Basingstoke: Macmillan, 1998, xii + 240 pp., £42.50.

R. J. Crampton, Eastern Europe in the Twentieth Century—and After. Second Edition. London: Routledge, 1997, xx + 526 pp., £50.00.

Richard & Ben Crampton, Atlas of Eastern Europe in the Twentieth Century. London: Routledge, 1997, xv + 297 pp., £16.99.

Jeffrey L. Roberg, Soviet Science Under Control: The Struggle for Influence. Basingstoke: Macmillan, 1998, xii + 169 pp., £42.50.

Vincent Barnett, Kondratiev and the Dynamics of Economic Development. Long Cycles and Industrial Growth in Historical Context. Basingstoke: Macmillan, 1998, xiv + 251 pp., £50.00.

Ronald Kowalski, The Russian Revolution 1917–1921. London: Routledge, 1997, xv + 269 pp., £13.99.

Arto Luukkanen, The Religious Policy of the Stalinist State. A Case Study: The Central Standing Commission on Religious Questions, 1929–1938. Helsinki: SHS, 1997, 214 pp.

J. Otto Pohl, The Stalinist Penal System: A Statistical History of Soviet Repression and Terror, 1930–1953. London: Macfarland, 1997, ix + 165 pp. £31.50.

Judith Pallot, Transforming Peasants: Society, State and the Peasantry, 1861–1930. Selected Papers from the Fifth World Congress of Central and East European Studies, Warsaw, 1995. Basingstoke, Macmillan, 1998, xix + 264 pp., £45.00.

Amy C. Singleton, No Place Like Home. The Literary Artist and Russia's Search for Cultural Identity. Albany: State University of New York Press, 1997, x + 193 pp, $17.95.

Stephen C. Hutchings. Russian Modernism: The Transfiguration of the Everyday. Cambridge: Cambridge University Press, 1997, xiii + 295 pp., £40.00.     

Theorizing about public expenditure decision-making: (as) if wishes were horses ...

There have been several attempts to compare different approaches to modelling public expenditure decision-making. This paper is an extended comment on one such attempt: Fred Thompson and Richard Williams, A Horse Race Around a Möbius Strip: A Review and a Test of Utility Maximizing and Organizational-Process Models of Public Expenditure Decisions. In a commentary mode, we: (a) examine why tests of the sort that Thompson and Williams offer are neither definitive in choosing between models nor very useful in improving models; (b) outline a more meaningful test procedure; and (c) offer a somewhat more critical view than Thompson and Williams of the utility-maximizing approach to modelling public expenditure decisions.A comment on Fred Thompson and Richard Williams, A Horse Race Around a Möbius Strip: A Review and A Test of Utility-Maximizing and Organizational-Process Models of Public Expenditure Decisions, in this issue of Policy Sciences.     

Political information processing: Question order and context effects

Data from two independent field experiments indicate that changes in question order and context may well account for an apparently precipitous decline of interest in politics at the time of the CPS 1978 American National Election Study. Evidence from a question order experiment with the SRC/CPS feeling thermometers also suggests that such contextual artifacts may not be atypical. Indeed, because of the many changes in the content and organization of the election studies over the years, context effects represent plausible rival hypotheses for a number of inexplicable shifts and trends in the time-series. In testing these hypotheses the authors derive and validate an information-processing model of how respondents infer their political states of mind from observations of their own question-answering behavior in the survey interview. In addition, the authors illustrate the wide applicability of the model tosubstantive problems in the discipline and its implications for the survey-based paradigm in political behavior research.