Successful DNA typing of a urine sample in a doping control case using human mitochondrial DNA analysis

In a doping control case, a urine sample was tested positive for nandrolon. We were asked by the athlete to perform DNA investigations on the questioned urine sample and compare these to a fresh blood sample taken from the athlete in order to detect or rule out manipulation and/or switching of the samples. The urine sample had been collected nine months prior to the investigation and had been stored at 4 degrees C. In a first approach, nuclear DNA systems were investigated that failed with the exception of the Amelogenin system. Due to the high copy number of mitochondrial DNA molecules and the robustness of the mitochondrial genome, we investigated the HVR I and HVR II regions of mitochondrial DNA and obtained reproducible and clear sequencing results for both the blood and the urine samples. Due to the identical sequences, it could not be excluded that the blood sample and the urine sample were from the same individual or an individual having the same maternal lineage.     

Dead Heat: The 2006 Public Choice Society Election

In 2006, the Public Choice Society chose a new president using approval voting. There were five candidates, and the election was extremely close. We indicate the sources of support of the different candidates, based in part on spectral analysis, by voters who cast between one and five votes. Using preference information that was also gathered, we show that two candidates different from the approval voting winner, including the apparent Condorcet winner, might have won under different voting systems. Because most voters did not indicate their complete preference rankings, however, these differences are hardly robust, especially since the outcome was essentially a dead heat.     

The Danes and Europe: From EC 1972 to Euro 2000 – Elections, Referendums and Attitudes

Within Europe, the Danish electorate is the one that has most often expressed its opinion about the European Union in elections and in national referendums. Votes and attitudes are analysed for the five elections to the European Parliament between 1979 and 1999 and in the six referendums – from the first on membership of the EC in 1972 to the September 2000 referendum on acceptance of the euro, the European single currency. The article gives an overview of the development of Danish public opinion in relation to the European Union from 1960 to 2000, the turnouts at referendums, and the elections and results for the European Parliament. It is shown that since Denmark joined the EU, public opinion has fluctuated greatly, although the balance among Danish European Parliament members has remained stable. The reasons for the frequent use of referendums in Denmark and a thematic outline of the six referendums are put forward. The article concludes with a comprehensive analysis of public attitudes towards the referendum on the euro in 2000. It is shown that regional electoral patterns have vanished, but underlying attitudes are manifested in the public.