Characterization of deletions in the DYS385 flanking region and null alleles associated with AZFc microdeletions in Koreans

Eight DYS385 allele size discrepancies and six DYS448 null types were detected among 708 Korean men when results of three in-house multiplex short tandem repeat (STR) systems were compared. The systems included both ordinary and reduced size amplicons. Sequence analysis revealed deletion mutations at two sites upstream of the DYS385 core repeats and deletion of the entire DYS448 locus. At DYS385, allele size differences were one or two repeats and were dependent on the primer set used for polymerase chain reaction (PCR) amplification. Location of the primer target sequence in a flanking region of the STR, distal or proximal to the deletion, determined allele size. Two widely used commercial kits amplify DYS385 so as to include the mutable sites. Arrangement analysis of sequence tagged sites demonstrated that the deletion patterns at DYS448 (and DYS464) were associated with arrangements of the azoospermia factor c gene (AZFc). The DYS448 deletion appears relatively frequent in Asians.     

A case of Ludwig angina: a case report and review of the literature

Ludwig angina is a rapidly progressing submaxillary, submandibular, and sublingual necrotizing cellulitis of the floor of the mouth that can have lethal consequences due to airway obstruction. Various aerobic and anaerobic microorganisms, and less often fungi, have been implicated to cause Ludwig angina, including oral flora such as streptococci and staphylococci. Early recognition and the use of parenteral antibiotics can prevent mortality and morbidity. We report a case of a 25-year-old white man who was admitted to the hospital by his dentist after being diagnosed with Ludwig angina secondary to periodontal abscesses involving teeth #17 and #32. Although antibiotics were administered, while in the hospital, the decedent had difficulty swallowing and was drooling. He suddenly began to have seizure-like activity thought to be anoxic myoclonus. The decedent was aggressively resuscitated and taken to the operating room for neck exploration and a tracheostomy. Neck exploration revealed severe necrotizing acute inflammation of the deep soft tissues and musculature of the neck. He remained on life support for 7 days until he was declared brain dead. Ludwig angina is a progressive cellulitis that often results in death by asphyxia. Ludwig angina can be complicated by subsequent deep neck infection. The underlying etiologies and common scenarios are examined, and significant autopsy findings and dissecting procedures are discussed. The pathophysiology of Ludwig angina is studied with a review of the current literature.     

Leave or stay? Battered women's decision after intimate partner violence

Battered women's reasons for staying with or leaving their male partners are varied and complex. Using data from the Domestic Violence Experience in Omaha, Nebraska, a discrete-time hazard model was employed to examine a woman's decision based on four factors: financial independence, witness of parental violence, psychological factors, and the police response to the domestic violence call. Findings regarding the first three factors are consistent with previous findings. However, a negative police response did not deter a woman from leaving, which is a different finding from previous studies.     

基于地区形势认识模式，东北亚地区合作应对核灾难

具有地缘政治学上特殊关系的韩中日三国，在核安全及应对核灾难时，不该仅仅从本国利益出发，而应该从区域公共财产的层面考虑问题。福岛核辐射事件呼吁三国加强区域合作的紧急需要。应对核灾难的东北亚地区合作，不是仅从简单的多变合作关系框架出发，而是为了保证作为地区公共财产安全的核安全，作为地区形势认识模式，提出了系统而具体的核灾难应对模式，提出了将制度性框架和具体合作方案进行系统联结的理论模式。基于Endsely的地区形势认识模式，地区形势认识模式由认识-理解-预测这三个阶段组成。在实践层面，地区形势认识模式可以被应用为建设系统而具体的东北亚应对核灾难的合作机制。为了构筑基于地区形势认识的东北亚合作体系，首先要在保证三国合作连续性的政治意志，其实要设定围绕地区合作方向性的竞争结构及与其他地区的关系，最后，为确保三国合作的有效性，有必要设立更加具体而有约束力的制度措施。     

The Diagnostic Frame in National Security Evaluations

In clinical and most forensic evaluations, “diagnosis” connotes the expectation of a DSM‐5 or ICD‐10 formally labeled mental condition. When the task is to evaluate the security risk a person's psychological makeup presents to an institution, such a molar diagnosis can blind the clinician and elevate the risk to a security agency. When “diagnosis” connotes achieving an understanding of a person's behavior that has raised security concerns, then a different conceptualization of the diagnostic process is required. Unlike the clinical situation, the evaluation is not being performed to benefit the person but for the purpose of assessing risk to an agency. The differences this introduces involve every aspect of the evaluation and changes the type of diagnosis expected. Not appreciating these differences can cause the clinician to fail in the task of assessing psychological tendencies that affect national security.     

The Effect of Age Structure on the Abrogation of Military Alliances

Scholars of alliance politics have ignored a potentially important factor that shapes foreign policy: the age structure of a state. In this article, we argue that an alliance member is more likely to terminate the alliance in violation of the terms when the state’s youth ratio is high. The demographic pressure of a high youth ratio raises potential for political instability domestically, which in turn increases the risk of radical foreign policy changes. We demonstrate the effects of a state’s age structure on its alliance policy by examining alliance termination by violation from 1950 to 2000. Through quantitative analysis, we find that youth ratio is a strong and significant predictor of alliance abrogation. A brief examination of several examples illustrates two paths by which the pressure created by a high youth ratio contributes to political instability and results in alliance abrogation—leadership change that brings about a new foreign policy and appeasement of the population through abrogation of an unpopular alliance.     

International Signaling and Economic Sanctions

Do economic sanctions serve international signaling purposes? A fully structural statistical model that employs a signaling game as a statistical model is used to investigate the existence of signaling effects of sanctions. Estimation results suggest that sanctions fail to work as a costly signal. The cheapness of sanctions prevents a target state from being able to distinguish a resolute sender state from a sender who is bluffing. When sanctions are imposed, a target rarely updates its initial evaluation of the sender state’s resolve, much less than when a military challenge is observed.     

The Clean Development Mechanism: A Bane or a Boon for Developing Countries?

We analyse the gains to developing countries from the participation in the CDM during the Kyoto period (until 2010) in the event an emissions trading (ET) regime exists in the post-Kyoto period (2010–20). We show that the developing countries will always be better-off participating in the CDM if the emissions quota they get in the post-Kyoto period is not linked to their baseline emissions. However if their quota equals (or is related to) their baseline emissions, CDM participation strategy may be a preferred alternative only if the CDM price is high enough to off-set the losses of the post-Kyoto period (during ET regime) due to participation in the CDM. We simulate the CDM and ET in the Kyoto and post-Kyoto period and show that with the reduction targets given in the Kyoto Protocol for Annex B countries, participation in the CDM is beneficial to non-Annex B (developing) countries, even if their emissions quota in the post-Kyoto period (during ET regime) is determined by their baseline emissions. Abatement supply price in the post-Kyoto period however turns out to be crucial factor in this case.