Survival of severe amlodipine intoxication due to medical intensive care

We report the case of attempted suicide with amlodipine, chlorthalidone and mefenamic acid and subsequent medical intensive care measures which resulted in total recovery of a 42-year-old male. After admission to the medical intensive care unit the intoxicated patient was deeply hypotensive and needed fluid replacement, dobutamine and norepinephrine. Additionally insulin and calcium gluconate were given. Since hypotension persisted and the patient developed oliguria, terlipressin was applied and finally showed an effect on blood pressure and on urinary output. A volume overload of 7 L in the first 24 h resulted in a pulmonary edema. The patient was started on non-invasive ventilation with continuous positive airway pressure (CPAP) and frusemide was added to the therapy with good success. Quantitative determination of amlodipine in plasma samples was performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The highest amlodipine concentrations was measured in the plasma sample collected approximately 8 h after ingestion of the drug, and was 393 microg/L. Four days later, it was possible to stop the treatment with catecholamines, at that time the amlodipine plasma concentration had declined to 132 microg/L, still tenfold higher than therapeutic (5-18 microg/L). Elimination half-life of amlodipine is approximately 55 h. After 6 days in the intensive care unit the patient was transferred to psychiatric treatment. Intensive care management and plasma levels in this intoxication case are compared to data from literature on other cases.     

Bedroom rape: sequences of sexual behavior in stranger assaults

This article examines the sequential, temporal, and interactional aspects of sexual assaults using sequential analysis. Fourteen statements taken from victims of bedroom-based assaults were analyzed to provide a comprehensive account of the behavioral patterns of individuals in sexually charged conflict situations. The cases were found to vary in the sexual severity of assault, distinguishing a variety of motivations and behavioral repertoires of offender and victim. Two quite distinct styles of offense were identified: multiple and single, which may have very different implications for research into rapist taxonomies and rape prevention strategies.     

Sixth Graders’ Conflict Resolution in Role Plays with a Peer,Parent, and Teacher

This study used conflict resolution role play vignettes and self-report surveys of 450 New York City 6th graders to examine associations between adolescents’ conflict resolution efficacy and social skills. Vignettes covered 3 social contexts, conflict with a peer (disagreement over activities), with a parent (raise in allowance), and with a teacher (low grade on report). Effective and ineffective strategies for resolving these conflicts were coded from the videotaped interactions. Adolescents were more often effective in resolving conflict with peers than with parents (χ²(1) = 7.10, p < .01). Strong communication skills cut across interpersonal context as associated with effective resolution. Assertiveness and absence of aggression were associated with effective conflict resolution in vignettes with peers. Assertiveness was also associated with effective conflict resolution in vignettes with parents, however nervousness was unexpectedly found to facilitate conflict resolution in vignettes with parents. Only skills observed within a particular context were associated with effective resolution in that context; self-report skills and cross-context observed skills were not associated with efficacy. Implications for implementation and evaluation of social skills curricula and conflict resolution process are discussed.An earlier version of this paper was presented at the meetings of the Society for Research on Adolescence, New Orleans, LA, April 2002Received Ph.D. in Developmental Psychology from Teachers College, Columbia University in 2004. Research interests include adolescent social competence and youth development programs.Received Ph.D. in Developmental Psychology from Pennsylvania State University in 1991. Research interests include the psychosocial correlates of puberty, stress reactivity, and health compromising behaviors and adjustment.Received Ph.D. in Developmental Psychology from Teachers College, Columbia University in 2002. Research interests include social competence, prevention research, and women’s health.Received Ph.D. in Developmental Psychology from Teachers College, Columbia University in 2002. Research interests include social competence, prevention research, and women’s health.Received Ph.D. in 1975 from University of Pennsylvania in Human Learning and Development. Research focus centers around designing and evaluating interventions aimed at enhancing the wellbeing of children living in poverty and associated conditions. Conducts research on transitional periods during childhood and adolescence, focusing on school, family and biological transitions in childhood, adolescence, and adulthood. Specific interests are in the factors that contribute to positive and negative outcomes, and changes inwell-being over these years.Received Ph.D. in Developmental Psychology from Columbia University in 1977. Research interests include tobacco, alcohol, and drug abuse prevention, violence prevention, AIDS risk reduction among adolescents, health promotion and disease prevention, smoking cessation.     

Driving Priorities in Risk‐based Regulation: What's the Problem?

Both risk‐based and problem‐centred regulatory techniques emphasize giving priority to matters that are serious and important. In the case of both risks and problems, however, issues of identification, selection, and prioritization involve inescapably normative and political choices. It is important, therefore, to understand why regulators target the risks and problems that they do; which factors drive such choices; and how regulation is affected when these factors pull in similar or opposite directions. Such an understanding provides a fresh framework for thinking about the challenges of both risk‐based and problem‐centred regulation. The analysis presented here does not oppose either risk‐based or problem‐centred regulation, but it illustrates why neither is as straightforward as simple calls for ‘better regulation’ may suggest, and it proposes ways in which key aspects of those challenges may be addressed.     

Mapping and Explaining Parliamentary Rule Changes in Europe: A Research Program

We outline a comprehensive research program on institutional reforms in European parliaments. Original data show that parliamentary rules in Western European parliaments have been changed frequently and massively during the period from 1945 to 2010 suggesting that actors use institutional reforms as a distinct strategy to pursue their substantive goals. We discuss how institutional instability affects existing theoretical and empirical arguments about institutional effects. Furthermore, we present four ideal‐typical approaches to analyzing rule changes, present new software tools for identifying and coding changes in large text corpora, and demonstrate their usefulness for valid measurement of the overall change between subsequent text versions.     

Confidently Wrong: Police Endorsement of Psycho-Legal Misconceptions

Public beliefs about psychological issues relevant to the legal system have been demonstrated to often be misconceived, but the endorsement of such beliefs in law enforcement samples is largely unknown. This study was the first to compare psycho-legal beliefs between law enforcement officers and the general public in the UK. Participants were presented a 50-item questionnaire measuring five psycho-legal topics; police procedures, courts, tough on crime, mental illness, and memory and cognition. Despite direct involvement and relevant experience, law enforcement officers endorsed just as many empirically contradictory beliefs as those who were not law enforcement officers. Further, law enforcement officers were more confident in their responses. This research has implications for identifying areas of limited knowledge within police samples that can be targeted by police education.     

“Contingent power extension” and regional (dis)integration: China’s Belt and Road Initiative and its consequences for the EU

In this article, we explore the Belt and Road Initiative (BRI) as a case of “Contingent Power Extension” (CPE) towards the European Union (EU), assessing its implications for regional (dis)integration in the latter. CPE is a conceptual prism that interprets the BRI as a polymorphous, dynamic, and context-specific mechanism through which Chinese foreign policy elites intend to convey, amplify, and legitimize the regime’s power-reach into other regions, including the EU. Along two examples—the 14 + 1 Cooperation Forum and the Port of Genoa in Italy—we examine the power dynamics of the BRI by tracing (a) the processual impact of power extension towards the EU and (b) the (un)intended consequences for the EU in terms of (dis)integration. The findings of our analysis provide an insight into the multicausal relations between the BRI and European (dis)integration not as a static outcome but rather as a contested process of struggle. The article concludes by discussing whether and how the EU can strengthen its own institutional foundations and use its systemic leverage to respond to the BRI while enhancing regional integration in the process.

     

Transgression Wrongfulness Outweighs its Harmfulness as a Determinant of Sentence Severity

When students suggest sentences for criminal offenders, do they rely more heavily on the harmfulness or on the wrongfulness of the offender's conduct? In Study 1, 116 Princeton University undergraduates rated the harmfulness and wrongfulness of, and suggested appropriate sentences for, a series of crimes. As expected, participants emphasized wrongfulness when choosing an appropriate criminal punishment. In Study 2, 33 Princeton undergraduates made similar ratings for violations of the University Honor Code, and rated their contempt for fabricated amendments to the Code that required sentencers to focus either only on harmfulness or only on wrongfulness. Again, sentences more closely reflected wrongfulness ratings, and participants were more contemptuous of the harmfulness-based proposal. We also consider the theoretical and practical implications of these findings for sentencing laws and policy.     

A Three‐Locus,PCR‐based Method for Forensic Identification of Plant Material

Plant residue is currently an underutilized resource in forensic investigations despite the fact that many crime scenes, as well as suspects and victims, harbor plant‐derived residue that could be recovered and analyzed. Notwithstanding the considerable skill of forensic botanists, current methods of species determination could benefit from tools for DNA‐based species identification. However, DNA barcoding in plants has been hampered by sequence complications in the plant genome. Following a database search for usable barcodes, broad‐spectrum primers were designed and utilized to amplify and sequence the rbcL, trnL‐F, and rrn18 genetic loci from a variety of household plants. Once obtained, these DNA sequences were used to design species‐targeted primers that could successfully discriminate the source of plant residue from among the 21 species tested.     

The politics of government reorganization in Western Europe

The reorganization of governments is crucial for parties to express their policy preferences once they reach office. Yet these activities are not confined to the direct aftermath of general elections or to wide-ranging structural reforms. Instead, governments reorganize and adjust their machinery of government all the time. This paper aims to assess these structural choices with a particular focus at the core of the state, comparing four Western European democracies (Germany, France, the Netherlands, and United Kingdom) from 1980 to 2013. Our empirical analysis shows that stronger shifts in cabinets' ideological profiles in the short- and long-term as well as the units' proximity to political executives yield significant effects. In contrast, Conservative governments, commonly regarded as key promoters of reorganizing governments, are not significant for the likelihood of structural change. We discuss the effects of this politics of government reorganization for different research debates assessing the inner workings of governments.