Sarcomeric gene mutations in sudden infant death syndrome (SIDS)

In developed countries, sudden infant death syndrome (SIDS) represents the most prevalent cause of death in children between 1 month and 1 year of age. SIDS is a diagnosis of exclusion, a negative autopsy which requires the absence of structural organ disease. Although investigators have confirmed that a significant percentage of SIDS cases are actually channelopathies, no data have been made available as to whether other sudden cardiac death-associated diseases, such as hypertrophic cardiomyopathy (HCM), could be responsible for some cases of SIDS. The presence of a genetic mutation in the sarcomeric protein usually affects the force of contraction of the myocyte, whose weakness is compensated with progressive hypertrophy and disarray. However, it is unclear whether in the most incipient forms, that is, first years of life, the lack of these phenotypes still confers a risk of arrhythmogenesis. The main goal of the present study is to wonder whether genetic defects in the sarcomeric proteins, previously associated with HCM, could be responsible for SIDS. We have analysed 286 SIDS cases for the most common genes implicated in HCM in adults. A total of 680 mutations localised in 16 genes were analysed by semi-automated matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDITOF-MS) using the Sequenom MassARRAY(?) System. Ten subjects with completely normal hearts showed mutated alleles at nine of the genetic variants analysed, and one additional novel mutation was detected by conventional sequencing. Therefore, a genetic mutation associated with HCM may cause sudden cardiac death in the absence of an identifiable phenotype.     

Mapping research on strategic alliances and innovation: a co-citation analysis

Using co-citation analysis, the present study attempts to rationalize and organize the combined alliance and innovation literature in order to determine its intellectual structure (i.e. its shared attributes such as models, theories, methods, findings, and implications), as well as to gain a deeper understanding of the most important research trends. More specifically, our goals are: (1) to delineate the intellectual structure of research on alliance and innovation, as represented in the academic literature; (2) to determine the subfields that constitute the intellectual structure and the relationships, if any, between these subfields; (3) to identify contributions that play a pivotal role in bridging two or more conceptual domains of research; and finally, (4) to map the intellectual structure in a two-dimensional space in order to visualize spatial distances between intellectual themes. Implications for future studies are then drawn.     

Bullying prevention programs: the importance of peer intervention, disciplinary methods and age variations

Objectives

The aim of this paper is to respond to the commentary of Peter K. Smith, Christina Salmivalli, and Helen Cowie (Journal of Experimental Criminology, 2012), who raise concerns regarding some of the findings of our systematic review and meta-analyses on the effectiveness of bullying prevention programs. They target three findings in particular: (1) the significant association of ??Work with Peers?? with greater victimization; (2) the significant association of ??Disciplinary Methods?? with less bullying perpetration and victimization; and (3) the age variations in effectiveness, suggesting larger effect sizes for older age students.

Methods

We provide explicit information and further detailed analyses on the relationship between these features and effect sizes, including heterogeneity tests and results from weighted regression analyses. For one element in particular (work with peers), we present further research findings from evaluations conducted by Smith, Salmivalli, and Cowie (and also findings from other independent researchers) which support our previous findings. New within-program analyses to examine variations in effect sizes with the age of the students are also presented.

Results

Evaluations conducted by Smith, Salmivalli and Cowie (and by other independent researchers) indicate the same research conclusions: although peer support schemes appear effective based on attitudinal surveys, these schemes are not related to actual levels of bullying or victimization and, in fact, are quite often related to an increase in bullying and victimization. Our definition of ??disciplinary methods?? did not include the zero-tolerance approach or any type of harsh discipline as suggested in the commentary. In all relevant cases, ??disciplinary methods?? included sanctions within a warm and loving framework, following the Olweus bullying prevention guidelines. While most programs that utilized firm disciplinary methods were inspired by Olweus, the relationship between disciplinary methods and less victimization was not driven by the Olweus program (which was not related to the victimization effect size). Larger effect sizes (i.e. reductions in bullying and victimization) for programs implemented with older students is a robust result also found in a more recent systematic review regarding the effects of anti-bullying programs on bystander intervention. In within-program analyses, most results suggested that effect sizes were greater for younger students, but these results were driven by the less controlled evaluations. The most controlled evaluation (randomized experiment) provided the opposite result.

Conclusions

More research is clearly needed on the effectiveness of bullying prevention programs with students of different ages, and we also recommend randomized experiments to assess the importance of different intervention components.     

The ‘Regulatory State’ in Higher Education: Assuring Quality through New Modalities of Control in Brazil

The Brazilian Higher Education (HE) sector, following a global trend of rapid transformation, has undergone marked changes over the past two decades. These changes have involved the design of quality assurance tools as instruments for regulatory governance. In presenting an overview of the recent history and characteristics of quality assurance in the Brazilian HE sector, this paper contextualises the Brazilian experience according to broader conceptual frameworks and discusses how and why regulatory governance in this sector has so radically changed.     

Note – Walking on Solid Ground: A Replication Study of ‘Housing Health and Happiness’

This note summarises our replication study ‘Housing, Health, and Happiness’, henceforth HHH2009, which constitutes an important paper in the literature of housing and slum upgrading. The original authors conduct a quasi-experimental impact evaluation of ‘Piso Firme’, an intervention that replaced in-house dirt floors with cement in Mexico. We conduct a Pure Replication (PR), a Measurement and Estimation Analysis (MEA), and a Theory of Change Analysis (TCA). In our PR, we did not find any major discrepancy with the original study. In the MEA, we generally find the results to be strongly robust to different types of alternative analysis. Finally, in TCA we explore a dimension that was not reported on the published version of the study and found that households with high initial levels of cement-floor coverage benefitted significantly less from Piso Firme’s intervention. These findings are discussed in greater detail on International Initiative for Impact Evaluation’s (3ie) working paper version.     

Spousal Bargaining Over Care for Elderly Parents in China: Imbalances in Sex Ratios Influence the Allocation of Support

Using a unique Chinese survey of parents and adult children, this paper examines how married children negotiate with their spouses for time devoted to caring for their own parents. Applying a collective bargaining framework, I show that the sex ratio at marriage shifts household bargaining in favour of the husband’s parents when women are less scarce, or against his parents when women are scarcer. Such changing dynamics in the family may potentially reverse the current preference for sons in China, implying that those with sons, rather than daughters, may be increasingly in need of state support.     

Techniques of Knowing in Administration: Co‐production,Models, and Conservation Law

Law frequently demands the production, sometimes effortful, of adequate knowledge for decision making. This article explores the challenging epistemic demands made by nature conservation law during planning law approval processes for major offshore wind farms. It explores this area through the prism of co‐production: not only are ‘science’ and ‘facts’ socially and legally constructed, but in addition, scientific and factual findings shape society, and law and governance. Models are used in planning law to assess whether bird deaths associated with a proposed wind farm will have an adverse effect on the integrity of a protected site. As much as providing an accurate factual representation of the impact of a wind farm on biodiversity, the models contribute to the very possibility of governing the impact of these novel infrastructure developments on biodiversity.     

Substance use and Sexual Orientation: A Test of Hirschi’s Social Bonds Theory

A substantial amount of research assesses the ability of Hirschi’s social bonds theory to explain numerous deviance oriented outcomes. In addition to amassing support for the theory, studies have also examined social bonds from sex and racial perspectives finding variations in bond strengths. Despite the impressive body of literature, one area that has yet to be explored is how social bonds and their relationships with deviance may vary between sexual orientation groups. Thus, the current study sought to compare the strength of social bonds and assess how social bonds can predict substance use between heterosexuals and non-heterosexuals. Self-reported data collected from 626 college students was examined using linear and logistic regression models. Results revealed that social bonds tend to be stronger and better predictors of substance use for heterosexuals. This study is the first of its kind to explore social bonds as a predictor between sexual orientation groups. Results indicate there is a need to further explore the strength of social bonds as predictors between sexual orientation groups. Heterosexuals and non-heterosexuals have different experiences as a result of their sexual orientation leading to varying relationships between social bonds and deviance.