Effects of individual dental factors on genomic DNA analysis

The use in forensic medicine of methods pertaining to molecular biology has made it possible to identify human remains through the analysis of polymorphic profiles of human DNA. Voluntary, accidental, or natural postmortem degradation, as well as environmental conditions, influences the preservation state of the corpse, making it sometimes difficult to obtain biologic material suitable for genetic analysis (e.g., hair, soft and/or hard tissue). According to their anatomic/morphologic characteristics, dental formations are particularly resistant to external insults and are thus suitable for this kind of research. The purpose of this work, conducted on nonselected dental findings (presenting intrinsic characteristics similar to those usually found in forensic cases) that were homogeneous with regard to environmental factors, was to determine an operative protocol that will enable combination of the maximum availability of genomic DNA with the preservation of the morphologic characteristics of the tooth for classic anthropologic evaluations.     

Forensic medicine experiences with methadone substitution in the Geneva canton

Methadone treatment for heroin addiction has followed three distinct periods in Geneva, Switzerland. The first period (1970-1979) corresponds to the beginning of the heroin addiction epidemic. Treatment was restricted to detoxification and did not succeed in reducing fatal overdoses. During the second period (1980-1989), methadone maintenance program was favoured but access to this program was limited. This period has brought a decrease of illegal heroin consumption and criminality but not of fatal overdoses. Finally, during the third period (since 1990), legislation was changed to allow easier access to methadone maintenance program. As a consequence there was a significant drop in lethal heroin overdoses and in deaths attributed to HIV.     

重修丝绸之路:迈向亚洲一体化

丝绸之路是指将东亚、中亚、南亚与地中海沿岸国家(包括北非和欧洲)连接在一起的、纵横交错的泛亚贸易交通网络。在过去的几十年中,随着全球化的不断深入,亚洲再度成为世界经济的重心。许多亚洲经济体成为了国际生产网络中不可分割的一部分,他们自身也从不断扩大的国际贸易、投资以及加速的经济增长中获益良多。然而,由于缺乏区域性连接,亚洲巨大的发展潜力尚未发挥出来。本文认为,缺乏全面的区域性连接是影响地区增长、阻碍亚洲乃至世界一体化进程的重要因素之一。鉴于此,亚洲应该加强地区通道建设,使之成为国际通道的一部分。本文还讨论了在通过泛亚运输基础设施建设实现地区连接的过程中,可能遇到的一系列问题和挑战。     

The effect of ECB communication on interest rates: An assessment

This paper reviews the literature on the communication policy of the European Central Bank (ECB) addressing two questions. First, to what extent has ECB communication affected interest rates? Second, to what extent has ECB communication affected the predictability of the ECB’s interest rate decisions? On the basis of a survey of empirical studies, it is concluded that various forms of ECB communication lead to more volatility. However, studies focusing on volatility cannot assess whether markets moved in the intended direction. To analyze whether this is the case, researchers have coded ECB communications. Studies using this approach yield evidence that communications generally move financial markets in the intended direction. There is also substantive evidence that ECB communications increase the predictability of interest decisions by the ECB Governing Council. Finally, the consequences of the fact that ECB officials often gave contrasting signals to market participants are analyzed. New evidence suggests that inconsistent communication causes agents to make less accurate predictions. The policy implication is that central bankers should take care that their statements are consistent.     

论创新党员学习机制

建设学习型政党，要求各级党组织引导党员立足本职，带头学习、加强学习、终身学习，使学习成为一种经常化、普遍化和制度化的行为。这就要从创新学习理念、学习制度、学习载体、学习工具等四个方面入手，探索创新党员长效学习机制，为建设学习型政党提供坚实的机制保证。     

Latent Fingermark Aging Patterns (Part III): Discontinuity Index as One Indicator of Degradation

This article is the third in a series of reports exploring quantifiable visual parameters of the aging process of latent fingermarks. On this occasion, research is focused on the occurrence of ridge discontinuities (i.e. breakages) as a function of time. Experiment variables included type of secretion (eccrine and sebaceous), substrate (glass and plastic), and exposure to natural light (dark, shade, and direct light) over a 6 months period. Fingermarks were sequentially visualized with titanium dioxide powder, photographed, and the number of naturally occurring ridge discontinuities subsequently evaluated. A semi‐quantitative value, named Discontinuity Index, was used to better characterize this aging parameter. Results indicated that ridges of sebaceous depositions on glass were generally less affected by the environmental conditions compared with those on plastic surface. In addition, aging in darkness was not always the best condition for preservation, and the direct exposure to light seemed not to affect the degradation under certain conditions.     

SURROGACY IN JAPAN: LEGAL IMPLICATIONS FOR PARENTAGE AND CITIZENSHIP

Japan has not yet regulated assisted reproductive technology by law. This lack of rules and regulations leaves to the courts the solution of numerous controversies, and puts patients in a situation of considerable uncertainty about their rights. First, the article uses a Supreme Court case on foreign surrogacy to discuss how courts should decide when there is a conflict between existing laws and the best interest of the child. Then, after describing the current situation and trends of surrogacy in Japan, the article examines a potential problem of coherence in prohibiting surrogacy and at the same time allowing adoption by the intended parents.     

Death Caused by Toxic Epidermal Necrolysis (Lyell Syndrome)

Abstract: Toxic epidermal necrolysis (TEN) is characterized by fever, scalded appearance of the skin, and epidermolysis associated to blister formation and exfoliation, and it is caused by hypersensitivity reaction to a drug. The authors report two cases of death as a result of TEN; both referred to old aged women treated with a polytherapy including allopurinol. Both patients displayed erythematous skin lesions similar to scald burns and epidermolysis at the face, chest, and abdomen and died shortly after hospitalization. Autopsy findings and histological examinations revealed epidermal necrolysis and confirmed the clinical diagnosis. A strict time‐correlation between allopurinol administration and symptoms was evidenced. Because of its iatrogenic origin, TEN often arises suspicions of medical liability; however, because of its unpredictable nature, the occurrence of this syndrome cannot be ascribed to the medical staff whose main task is the rapid diagnosis and the correct management.