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Loperamide is an over‐the‐counter, μ‐opioid receptor agonist commonly used as an antidiarrheal agent. Loperamide was thought to have minimal abuse potential due to its low bioavailability and limited central nervous system activity; however, there have been increasing reports of loperamide misuse in supratherapeutic doses to achieve euphoria and/or avoid opioid withdrawal. A literature review suggests a rise in loperamide abuse was inevitable, with substantial increases in reported cases over the last decade. Five fatal cases of toxic medication use where loperamide was listed as a primary or contributory cause of death were identified at the Medical University of South Carolina. The characteristic autopsy demographics and findings are described, and the mechanisms of abuse and toxicity of loperamide are reviewed. Loperamide overdoses are a growing concern from both a forensic and clinical standpoint, and the frequency of reported cases will likely increase as awareness grows within the medical and toxicological communities. 相似文献
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Anne Powell Williford Daniel Brisson Kimberly A. Bender Jeffrey M. Jenson Shandra Forrest-Bank 《Journal of youth and adolescence》2011,40(6):644-655
The developmental period characterized by the transition from childhood and elementary school to early adolescence and middle
school has been associated with increases in aggressive behavior and peer victimization. Few longitudinal studies, however,
have examined the stability of aggression and victimization during this critical transition. This study uses latent class
analysis (LCA) to examine patterns of aggressive behavior and victimization during the transition to middle school among urban,
public school students (N = 458; Girls = 53%; Latino/a = 53%; M age at t1 = 10.2 years). Independent LCA models were conducted using self-reported data assessing subjects’ involvement in
aggressive conduct and victimization during the spring semesters of grades four, five, and six. Elementary school students
in the fourth grade initially belonged to one of four groups identified as aggressor, victim, aggressor-victim, and uninvolved
latent classes. Contrary to prior research, membership in these classes changed significantly by the time students completed
their first year of middle school with most youth participating in episodes of aggression and victimization during the transition.
Six common paths that describe patterns of aggressive behavior and victimization from the last two years of elementary school
to the first year of middle school were found. Findings are discussed in the context of social dominance theory and prior
research that has found greater stability in aggression and victimization among early adolescents. 相似文献
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Powell BJ Passalacqua NV Baumer TG Fenton TW Haut RC 《Journal of forensic sciences》2012,57(2):312-317
The objective of this study was to document patterns of fracture on infant porcine skulls aged 2-28 days (n = 57) because of a single, high energy blunt impact to the parietal bone with rigid (nondeformable) and compliant (deformable) interfaces. Fracture patterns were mapped using Geographic Information System software. For the same generated impact force, the rigid interface produced more fractures than the compliant interface for all ages. This study also showed that this increased level of impact energy versus an earlier study using a lower energy resulted in new sites of fracture initiation and also caused previously defined fractures that propagate into an adjacent bone. Several unique characteristics of bone and diastatic fracture were documented as a function of specimen age, impact energy, and interface. These data describe some baseline characteristics of skull fracture using an animal model that may help guide future studies from forensic case files. 相似文献
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Recent years have seen increased scholarly attention given to the issue of child soldiering. Primarily dedicated to the decision-making calculus of rebel groups, this body of work has generally emphasised supply-side versus demand-side arguments. We contribute to this growing literature by explicitly investigating a previously untested aspect of the latter. Prior scholarship has made vague references to a potential association between economic endowments and child soldiering, including natural resource wealth, but scant empirical attention has been given. We argue that the specific type of endowment has important consequences for the decision to utilise child soldiers. We argue access to and exploitation of lootable natural resources (e.g. gemstones) to be especially likely to promote the use of child soldiers due to their ease of access, the low skills required to harness them and the heightened likelihood that groups will become more profit-oriented. A systematic cross-national investigation of rebel groups provides robust evidence that lootable resources such as diamonds and gemstones are strongly associated with the use of children, while non-lootable resources such as oil are not. 相似文献
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Caitliń Jeffrey Pausé Kimberley Powell Hine Waitere Jeannie Wright marg gilling 《Feminist Review(on-Line)》2012,102(1):79-96
From four countries (Canada, England, New Zealand and the United States of America) and five disciplines (Counselling & Guidance, Adult Education, Early Years Education, Indigenous Education and Human Development), five feminists in academia come together to share how feminism affects their practice. Ranging in reflections on teaching, research, service and scholarship, this article describes a cooperative enquiry into feminism in action in Aotearoa, New Zealand. 相似文献