Genetic analysis of suicide: a sample study in Tuscany (Central Italy)

Many studies have examined the genetic contribution to suicide. However, data on suicide in the Italian population are scarce. We therefore aimed to address this gap by investigating a cohort of 111 Italians for whom a verdict of suicide had been declared in court in Florence, Italy between 2007 and 2017. This cohort included 86 men and 25 women. DNA samples were obtained from tissues or blood, and 22 genes from multiple neurobiological pathways previously shown to be associated with the pathogenesis of suicide were analysed. Next-generation sequencing was used to compare these gene sequences with those from a large, normal population. In this study, we identified 19 gene variants that were present at significantly lower frequencies in our Italian cohort than in the general population. In addition, four missense mutations were identified in four different genes: Monoamine Oxidase A (MAOA), 5-Hydroxytryptamine Receptor 2 A (HTR2A), Sodium Voltage-Gated Channel Alpha Subunit 8 (SCN8A), and Nitric Oxide Synthase 3 (NOS3). Our study identified several potential genetic links with suicide in a cohort of Italians and supports a relationship between specific genetic variants and suicidal behaviour in this population.     

Battered woman syndrome evidence in the courtroom

The use of battered woman syndrome evidence has been advocated in trials of battered women who assault or kill their abusers. The present article reviews existing legal and psychological literature addressing the use of this form of expert testimony. As the review will indicate, there are, at present, substantial gaps in our knowledge about its scientific status and its impact on legal proceedings. The goal of the article is to highlight some of the central concerns surrounding the use of bettered woman syndrome evidence and to encourage additional research on the subject.Thanks are extended to R. Lalonde for comments on earlier versions of this paper.     

Expert evidence and hearsay

In upholding the admission of expert evidence, some courts have held that hearsay information conveyed via an expert may be admitted as long as the jury is instructed to ignore the facts asserted in the hearsay statements and to use the information only for determining the weight to attribute to the expert's opinion. Results of a mock juror simulation indicated that although hearsay elements conveyed via an expert were perceived as less likely compared to a condition in which the information was independently admitted at trial, it was not completely ignored by the jurors. Further, the findings tended to suggest that the impact of the hearsay on verdict decisions operated primarily by influencing evaluations regarding the likelihood of the hearsay events as opposed to judgments regarding the expert testimony.     

Intellectual Capital and Public Management： A Bibliometric Analysis

Starting from the premise that public management, in the context from the emergent knowledge society, needs new forms to act and new tools to reach its objectives, this paper aims to find evidence of the adoption of the principles of intellectual capital under the public management, by raising scientific articles about the subjects, and aims to select theoretical referential about intellectual capital and public management, by bibliometric analysis. The processes presented 100 constant articles in the final portfolio, available in the data base Web of Science, Science Direct and Scopus. The bibliometric indicators show that the studies were published as from 1969, released by 15 international periodicals, written by 164 authors, used 241 key words related to the constructs of this study. It is believed that the identification of the main references helps the understanding of the foundations of this research field. Additionally, this paper provides many inputs that contribute to the comprehension of the subject at an international level, and that can be utilised in the development of future works.     

Validation of powder X-ray diffraction following EN ISO/IEC 17025

Powder X-ray diffraction (PXRD) is used widely in forensic science laboratories with the main focus of qualitative phase identification. Little is found in literature referring to the topic of validation of PXRD in the field of forensic sciences. According to EN ISO/IEC 17025, the method has to be tested for several parameters. Trueness, specificity, and selectivity of PXRD were tested using certified reference materials or a combination thereof. All three tested parameters showed the secure performance of the method. Sample preparation errors were simulated to evaluate the robustness of the method. These errors were either easily detected by the operator or nonsignificant for phase identification. In case of the detection limit, a statistical evaluation of the signal-to-noise ratio showed that a peak criterion of three sigma is inadequate and recommendations for a more realistic peak criterion are given. Finally, the results of an international proficiency test showed the secure performance of PXRD.     

Politicians,Scandals, and Trust in Government

In this paper we examine the role that political scandals play in eroding regard for government and political institutions in general. We know that scandals can lower regard for individual politicians and government leaders. Yet, less is known about how scandal influences attitudes toward institutions and the political process. It has been widely assumed that such attitudes are influenced by factors that lie largely beyond the control of individual politicians. Using data from the U.S. and the U.K. we show that scandals involving legislators can have a negative influence on their constituent's attitudes toward institutions and the political process. One consequence of this finding is that, instead of looking for scapegoats in Hollywood or among the failings of voters themselves, politicians should first get their own House in order.     

An eight-year follow-up: Outcome from adolescent compared to adult onset anorexia nervosa

Seventy-five women were traced and reassessed on average eight years after the onset of anorexia nervosa. All patients received treatment and 88% were hospitalized at least once. Comparisons between early (11–15 years; N=35), late (16–18 years; N=24) adolescent and adult (19–27 years; N=14) onset revealed no significant differences in outcome for age at onset. For 70% of adolescent and 42% of adult onset patients the outcome was good, meaning that the weight was within ± 15% of norm with regular cyclical menstruation,17% and 21% had an intermediate, and 9% and 21%, respectively, had a poor outcome, 5.3% had died. Taken together, 59% had physically recovered and were free of any eating disorder. Severity of illness reflected in a low body mass index, excessive exercise, and poor psychosocial functioning at intake were poor prognostic indicators;length of illness and food restriction or bulimia as eating patterns were unrelated to outcome. The observation that all women with chronic anorexia nervosa, and even a third of those who had physically recovered from anorexia nervosa, qualified for one or more psychiatric diagnoses suggests that the psychosocial correlates of anorexia nervosa require further study.Supported by grant MH ROI35585-01A1.Received an M.D.-Ph.D. degree from Albert-Ludwig University in Freiburg, Germany. Research interests have been depressive disorders, eating disorders, in particular anorexia nervosa, and more recently women's health.Received M.D. degree from the University of Illinois in Chicago, Illinois. Research interest is in preventive medicine.     

Gender,difference and dominance

Catharine MacKinnon, Feminism Unmodified: Discourses on Life and Law (Harvard University Press) Cambridge MA, 1987.     

Identity and anxiety: Germany’s struggle to lead

At a time when calls for German leadership abound, we need to ask what kind of leadership Berlin is likely to offer. This paper builds on scholarship that presumes identity as an essential precondition for orderly social life. My focus is on how identity is secured through ontological security-seeking. Ontological security theory reveals how Germany is responding to rising calls for leadership in Europe and beyond and traces these responses to an increasingly stressed identity narrative. It explains both Germany’s reluctance to lead and, being pressed to lead, how leadership is legitimated through discursive adaptation. Whether “leading from the center” or exercising “servant leadership”, ontological security theory exposes the specific interactions between a national self-narrative and a rapidly changing environment. I show how these interactions challenge Germany’s identity and its ability to adapt; how they cause ontological anxiety, and how the scope and direction of adaptation to structural change account for the kind of leadership Germany is able to offer. What we observe is a determined effort to position the country between a traditional culture of restraint that can no longer meet Germany’s responsibilities and a position of hegemony that speaks of self-serving behaviour and dominance.