Fatal intoxication involving 2-methyl AP-237

Novel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled “2MAP” and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was treated for a drug overdose 3 years prior to his death. With no diagnostic findings at autopsy, the case was submitted for toxicological analysis. An unknown substance was detected in peripheral blood and urine using gas chromatography with nitrogen phosphorous detection (GC-NPD). Further testing was conducted using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) which confirmed the presence of 2-methyl AP-237 and potential metabolites in blood and urine. Quantitation by GC-NPD revealed concentrations of 2-methyl AP-237 in blood and urine at 480 ng/mL and 4200 ng/mL, respectively. The toxicological analysis also identified and quantitated alprazolam in the blood at 55 ng/mL. Additionally, the metabolism of 2-methyl AP-237 was investigated and three hydroxylated metabolites were identified in peripheral blood and urine. Limited literature is available for the detection and quantitation of 2-methyl AP-237 in postmortem specimens. Given the toxicological findings with unremarkable autopsy findings, this case is an example of a fatal intoxication involving 2-methyl AP-237.     

State environmental regulators: perspectives about trust with their regulatory counterparts

Although numerous studies explore the regulatory enforcement styles of regulators and the regulated community's compliance motivations, existing research does not provide adequate insight into regulatory interactions themselves. We use data from a nationwide survey of more than 1200 state environmental regulators to empirically assess the role of trust in regulatory interactions. We find statistical support of trust in these regulatory interactions and find that trust appears to be a function of cooperative behavior, information sharing, respect, perceptions of motivations, and proactive assistance seeking. These findings could support the increasing calls for a fundamental restructuring of environmental regulation in favor of a next‐generation approach to environmental policy that calls for more collaborative working relationships between regulators and their regulatory counterparts. Copyright © 2014 John Wiley & Sons, Ltd.     

Better Politicians: If We Pay,Will They Come?

While each election provides the Canadian House of Commons with a fresh batch of politicians, no consideration has been given to the question of whether the quality of politicians is improving. Yet improving quality has been the focus of several commissions urging increases in MP compensation. This article addresses the competence and compensation questions by asking whether changes in levels of compensation might make a difference to the educational qualifications of political leaders. We assemble a unique dataset of 1,291 federal politicians elected to the Canadian House of Commons from 1993 to 2011 and show that prime ministers do have a preference for more highly educated MPs when filling ministerial and other executive positions. Our findings suggest that certain subgroups of MPs, particularly educated women, may be attracted by upward shifts in compensation. We discuss the reasons for these effects and the relative importance of compensation in career decisions.     

Coalition government and electoral accountability

Single-party governments are commonly thought to be more clearly responsible for government policy than coalition governments. One particular problem for voters evaluating coalition governments is how to assess whether all parties within a coalition should be held equally responsible for past performance. As a result, it is generally argued that voters are less likely to hold coalition governments to account for past performance. This article uses data from the Comparative Study of Electoral Systems project to assess whether and how the composition of coalition governments affects the way in which people use their votes to hold governments to account, and which parties within coalitions are more likely to be held to account for the government’s past performance.     

Voters and coalition governments

Coalition governments are the norm in parliamentary democracies. Yet, despite the predominance of this type of government, political scientists have only recently started to investigate how voters approach elections when a coalition government is the likely outcome. Such elections present additional uncertainty and complexity for voters compared with elections in plurality systems, where party choice translates more directly into a choice of government. These factors have lead to the assumption that strategic voting is unlikely to occur in systems that produce coalition governments. In this introductory article to the special issue on Voters and Coalition Governments, we consider whether voters have the capacity to anticipate specific coalition outcomes and propose a framework for understanding the conditions that lead to strategic voting in both plurality and proportional systems.     

Latent Fingermark Aging Patterns (Part IV): Ridge Width as One Indicator of Degradation

This fourth article of the series is taking an in‐depth analysis at the visible aging of latent fingermarks regarding changes in ridge widths over time. The objective is to quantify and statistically describe significant ridge size variations under controlled indoor conditions. The effect of three environmental variables are examined: type of secretion (sebaceous‐ and eccrine‐rich) and type of substrate (glass and polystyrene) when aged in three light conditions (direct natural light, shade, and dark). Prior to width measurements, fresh and aged fingermarks were powdered with titanium dioxide (TiO₂) and sequentially photographed at predetermined times over 6 months. Three independent observers measured the ridges from thirty predetermined locations using strategically placed intersecting lines on the print. Results indicate that fingermarks deposited on glass are more resilient to degradation compared with those deposited on plastic. The presence of direct natural light plays a negligible role on degradation compared to secretion and substrate types.