Molecular genetics of sudden cardiac death

Sudden cardiac death (SCD) is one of the most common causes of death. An important number of sudden deaths, especially in the young, are due to genetic heart disorders, both with structural and arrhythmogenic abnormalities. In recent years, significant advances have been made in understanding the genetic basis of SCD. Identification of the genetic causes of sudden death is important because close relatives are also at potential risk of having a fatal cardiac condition. A comprehensive post-mortem investigation is vital to determine the cause and manner of death and provides the opportunity to assess the potential risk to the family after appropriate genetic counselling. In this paper, we present an update of the different genetic causes of sudden death, emphasizing their importance for the forensic pathologist due to his relevant role in the diagnosis and prevention of SCD.     

On the Incoherence of Legal Language to the General Public

I will suggest, in this article, a possible explanation of the fact that legal language appears incoherent to the general public. I will present one legal text (an indictment), explaining why it appears incoherent to legal laypersons. I will argue that the traits making this particular text appear incoherent are, first, that a specialized legal meaning is conveyed implicitly and, second, that there are no key-words that could direct laypersons to the knowledge making this meaning obvious to legalists. I will conclude that any legal text having these traits is likely to appear incoherent to the general public and suggest that the traits making my example appear incoherent might be rather common among the various texts of the various legal systems. On this suggestion there is no need to assume any causal relation between lawyers’ social interests and the apparent incoherence of legal language as it entails that this incoherence is inevitable. (I will argue that it is a result of the facts that legal language is ordinary language used, in the ordinary way, in the special context of the legal discourse.)     

Fundamental Rights and Citizenship of the Union at a Crossroads: A Promising Alliance or a Dangerous Liaison?

The reinforcement of the protection of fundamental rights at the European level and the emergence of the status of Union citizenship are two closely connected phenomena. European citizenship has been and continues to be one of the central arguments in favour of the extension of the scope of EU fundamental rights. This argument arises out of a sentiment that vindicates equality at the core of the citizenship of the Union as a fundamental status. Against this background, this paper examines the different possibilities of interconnection between the traditional doctrine of EU fundamental rights and the jurisprudential construction of the citizenship of the Union. Particularly, it will be discussed whether fundamental rights should be placed at the core of the formula that protects the ‘genuine enjoyment of the substance’ of the rights conferred by EU citizenship, inaugurated by Ruiz Zambrano, already latent in Rottmann and substantially refined in an ever‐growing case‐law (McCarthy, Dereci, O. and S., Ymaraga and Alokpa). It will be argued that this formula carries the very valuable potential to reinforce citizenship of the Union as an independent source of rights able to overcome problems such as reverse discrimination. For these purposes, this formula could be considered to encompass not only the absolute deprivation of the ‘genuine enjoyment of the substance of citizenship rights’, but also the existence of serious obstacles thereto.     

Coefficient stability and structural change in the Spanish economy

The main aim is the study of coefficient stability using comparative analyses of Spanish input–output tables of recent decades. We try to provide answers to questions related to the nature and intensity of changes in the production structure, implementing procedures both of a direct nature as well as of an indirect one, following Mesnard’s proposal. We further raise the possibility of forecasting branch evolution by means of demand-driven or supply-driven models, depending on coefficient stability, in accordance with the work of Ranko Bon.

PMICALC: An R code-based software for estimating post-mortem interval (PMI) compatible with Windows,Mac and Linux operating systems

In legal medicine the correct determination of the time of death is of utmost importance. Recent advances in estimating post-mortem interval (PMI) have made use of vitreous humour chemistry in conjunction with Linear Regression, but the results are questionable. In this paper we present PMICALC, an R code-based freeware package which estimates PMI in cadavers of recent death by measuring the concentrations of potassium ([K+]), hypoxanthine ([Hx]) and urea ([U]) in the vitreous humor using two different regression models: Additive Models (AM) and Support Vector Machine (SVM), which offer more flexibility than the previously used Linear Regression. The results from both models are better than those published to date and can give numerical expression of PMI with confidence intervals and graphic support within 20 min. The program also takes into account the cause of death.     

From adolescence to adulthood: Development of psychopathology in kibbutz and town subjects

The unique contribution of the National Institute of Mental Health—Israeli longitudinal high-risk study is the comparison of the development of children at high risk for schizophrenia from two divergent socialization environments: the Israeli urban nuclear family and the collective education in the kibbutz. The study began with 100 preadolescent children who were followed up into adolescence, with outcomes measured in their 20s and 30s. No difference in the prevalence of schizophrenia was found at the last follow-up phase, with subjects at an average age of 32, but a higher incidence of major depression was found in the kibbutz than in the urban high-risk group. The data suggest adolescence as the period in which the differential effects of environment began to appear. Environmental factors, related to the social structure of the kibbutz, which may have led to this outcome, are discussed.Received Ph.D. in psychology from the Hebrew University, Jerusalem. Engaged in research on socialization in the kibbutz as well as in the NIMH-Israel High-Risk project, and is a practicing psychotherapist.Member of Kibbutz Biet-QeshetAn educational psychologist practicing within the Jerusalem school system. Has taken a leading part in the fourth phase of the NIMH-Israel High-Risk Study and currently completing a doctoral dissertation in psychology.Received Ph.D. from Columbia University. Has served as Chief Scientist of the Ministry of Education of Israel. Involved in the NIMH-Israel High-Risk Study from its start and has served as the Israeli principal investigator during its fourth phase.     

Agricultural Workers,Credit Rationing and Family Networks in Rural Mexico

Abstract

We use mixed methods and first-hand household data in Mexico to investigate credit practices by households engaged in agricultural wage employment. Quantitative analysis shows evidence of rationing in the formal sector but also suggests the existence of mitigating mechanisms. Qualitative analysis provides additional insights. First, income patterns associated with agricultural wage generate income smoothing needs that are sometimes better met by the informal sector. Second, family networks can perform key functions as gateways to the formal sector, through specific informal arrangements that inject flexibility into formal rules and procedures.     

Liberia: security challenges,development fundamentals

This research article argues that security challenges in post-conflict Liberia cannot be addressed effectively without synchronising current stabilisation policies with the implementation of development fundamentals. The article explores key strategic sectors of the Liberian economy and their impact on the security and development dimensions of peace building. The political economy of post-conflict Liberia has not structurally modified an economic model which relies on the concessionary system and the extraction of raw materials at the expense of developing productive sectors which could be used to secure sustainable livelihoods. It is suggested that a shift in the political economy pursued by national and international actors is needed to link current peacebuilding efforts to sustainable development processes; one policy measure recommended to achieve such a goal is enhanced support for land reform and small farmers' rights.     

Book Review

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