The importance of policy design fit for effectiveness: a qualitative comparative analysis of policy integration in regional transport planning

Policy Sciences - Policy design has returned as a central topic in public policy research. An important area of policy design study deals with effectively attaining desired policy outcomes by...     

Proteolytic‐Based Method for the Identification of Human Growth Hormone*

Abstract: Human growth hormone (HGH) is a relatively small protein consisting of 191 amino acids and has an average mass of 22,125 amu. The forensic analysis of proteins such as HGH must meet the analytical sufficiency requirements for the laboratory and consists of a binary approach. A suspected sample is analyzed as the whole protein for retention time and mass determination using high performance liquid chromatography equipped with a photodiode array and liquid chromatography mass spectrometry. Further fragmentation of the protein using a proteolytic enzyme adds another dimension to the specificity of the analysis. Porcine trypsin digests proteins in a very predictable manner and yields peptide fragments of the original protein that can be used as a means for fingerprinting the larger biomolecule. In silico, or theoretical, digestion of HGH by trypsin yields 21 peptides ranging in size from 1 to 23 amino acids in length. The larger fragments containing higher numbers of amino acids give more specificity to identifying a protein based on a fragment produced by the digestion of trypsin. Herein, the analysis of HGH using a proteolytic approach is presented that meets the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) recommendations for the identification of unknown substances.     

On the superiority of damage averaging in the case of strict liability

The literature argues that if injurers cannot anticipate the precise level of harm, courts might use expected harm as a magnitude of compensation instead of actual harm without distorting care incentives. This paper shows that the use of expected harm is in fact preferable if victims choose the value of the object placed at risk. If the court were to insist on compensating actual harm, this would result in victims choosing inefficient object values. In contrast, restricting compensation to expected harm yields the first-best outcome.     

Mediation: important preliminary questions: trustee's duties in trust disputes and trustee's powers of compromise

Before trustees can proceed to mediation, they need to knowwhether they have a duty to resist the claim that is being mediated.Before entering into mediation, trustees need to understandits duties in relation to the claim, and the scope of compromise.Applications for blessing are two ways of protecting to enterinto a compromise. These are considered in this article.     

Betting shops in the public eye: A commentary

Betting shops are a familiar feature in towns and cities throughout the UK. However, in recent years, increasing social and political concerns have been expressed about the presence of betting shops in high streets and about the role of betting shops in encouraging gambling. Such concerns include the concentration of betting shops in areas of social deprivation, the impact of such shops on the vitality of and viability of town centres, the perceived links between betting shops and both anti‐social behaviour and criminal activity and the presence of Fixed Odds Betting Terminals in betting shops. This commentary paper outlines the origin and characteristics of betting shops, explores some of the recent concerns betting shops have attracted and offers some brief concluding reflections on the impact of policy responses to these concerns.