Hans Georg Ruppe – 65 Jahre

Ohne Zusammenfassung     

A collaborative study of the EDNAP group regarding Y-chromosome binary polymorphism analysis

A collaborative study was carried out by the European DNA Profiling Group (EDNAP) in order to evaluate the performance of Y-chromosome binary polymorphism analysis in different European laboratories. Four blood samples were sent to the laboratories, to be analysed for 11 Y-chromosome single nucleotide polymorphisms (SNPs): SRY-1532, M40, M35, M213, M9, 92R7, M17, P25, M18, M153 and M167. All the labs were also asked to submit a population study including these markers. All participating laboratories reported the same results, indicating the reproducibility and robustness of Y-chromosome SNP typing. A total of 535 samples from six different European populations were also analysed. In Galicia (NW Spain) and Belgium, the most frequent haplogroup was R1b*(xR1b1,R1b3df). Haplogroup F*(xK) is one of the most frequent in Austria and Denmark, while the lowest frequency appear in Belgium. Haplogroup frequencies found in this collaborative study were compared with previously published European Y-chromosome haplogroup data.     

Federalism and Education Planning in the Federal Republic of Germany

In 1969 demands for greater rationality in education planninggave rise to new institutionalized forms of cooperation betweenthe federation and the Länder. Conflicts between the federaland Land governments, partisan conflicts, and financial conflictsoverlapped this cooperation. Despite the fact that the formalcapacity for dealing with conflicts had many shortcomings, ajoint general plan for education was issued in 1973 as a resultof favorable economic and political conditions. However, in1978 the federal government failed in its attempt to utilizethe dissatisfaction with the existing system of cooperationto extend its responsibilities for education. The deteriorationin economic and political conditions led to an end of effortsto formulate a general plan for education in 1982 and reducedthe scale of joint activities. Forms of educational cooperationbetween the federation and the Länder still exist, butthey no longer fulfill their original purpose. The centralizationof decisionmaking, which was originally expected, never cameinto being.     

Cornerstones of a Civilized Society: Law,Morality, Faith and Spirituality

The linkages among law, morality, faith and spirituality are historically accepted. Yet, the separation between law and morality/faith/ spirituality have also been accepted and expected in order to preserve the traditional separation of church and state. Nevertheless, application, infusion and adoption of legal, moral, faith and spiritual principles have been the cornerstones of the building of this country for almost three centuries. Recently, and increasingly, those cornerstones are being chipped away. Stated more succinctly by Selleck and Josephson (1995). “There is a hole in the moral ozone and we've got to fix it” (p. 53). This paper explores and revisits the unique contributions of each and the connectedness among law, morality, faith and spirituality as partners in refurbishing the cornerstones that can support this nation securely into the next millennium. While examined separately, it is clear that these four components of lifespan development are not mutually exclusive and overlap considerably, both historically and in modern society. Included are models of morality, faith development and spirituality which may provide the reader with concrete touchstones for reflective thought.     

Subnuclear renal tubular vacuoles in alcohol use disorder

Subnuclear vacuoles in the proximal renal tubules have been reported as a histologic sign of ketoacidosis. Originally described in diabetic ketoacidosis, renal vacuoles can be found in other ketogenic states such as alcoholic ketoacidosis (AKA), starvation, and hypothermia, underpinned by deranged fatty acid metabolism. A retrospective analysis of 133 deaths associated with alcohol use disorder (AUD) examined at autopsy between 2017 and 2020 was undertaken. This study aimed to determine the prevalence of subnuclear vacuoles in deaths of those with AUD and their specificity for deaths from AKA, and to elucidate what demographic, biochemical, and pathologic findings are associated with subnuclear vacuoles. In each case, vitreous humor biochemistry including electrolytes, glucose, and beta-hydroxybutyrate (BHB) was analyzed alongside postmortem hemoglobin A1c and renal and liver histology. Renal histology was graded for the presence of vacuoles as absent (0), scanty (1), or easily identifiable (2). Liver histology was graded for steatosis and for fibrosis if Masson trichrome staining was available. Vacuoles were commonly seen in the deaths of those with AUD. They were seen in deaths due to AKA but were not specific to that cause of death. With vacuoles present, lower vitreous sodium (139 vs. 142 mmol/L; p = 0.005), higher vitreous BHB (1.50 vs. 1.39 mmol/L; p = 0.04), severe hepatic steatosis, and severe hepatic fibrosis were seen, compared with those without renal vacuoles.