Review of analytical methods for screening and quantification of fentanyl analogs and novel synthetic opioids in biological specimens

Fentanyl, fentanyl analogs, and other novel synthetic opioids (NSO), including nitazene analogs, prevail in forensic toxicology casework. Analytical methods for identifying these drugs in biological specimens need to be robust, sensitive, and specific. Isomers, new analogs, and slight differences in structural modifications necessitate the use of high-resolution mass spectrometry (HRMS), especially as a non-targeted screening method designed to detect newly emerging drugs. Traditional forensic toxicology workflows, such as immunoassay and gas chromatography mass spectrometry (GC–MS), are generally not sensitive enough for detection of NSOs due to observed low (sub-μg/L) concentrations. For this review, the authors tabulated, reviewed, and summarized analytical methods from 2010–2022 for screening and quantification of fentanyl analogs and other NSOs in biological specimens using a variety of different instruments and sample preparation approaches. Limits of detection or quantification for 105 methods were included and compared to published standards and guidelines for suggested scope and sensitivity in forensic toxicology casework. Methods were summarized by instrument for screening and quantitative methods for fentanyl analogs and for nitazenes and other NSO. Toxicological testing for fentanyl analogs and NSOs is increasingly and most commonly being conducted using a variety of liquid chromatography mass spectrometry (LC–MS)-based techniques. Most of the recent analytical methods reviewed exhibited limits of detection well below 1 μg/L to detect low concentrations of increasingly potent drugs. In addition, it was observed that most newly developed methods are now using smaller sample volumes which is achievable due to the sensitivity increase gained by new technology and new instrumentation.     

Reframing the brain drain

Theorists concerned about the distributive effects of skilled emigration (‘brain drain’) often argue that its harmful effects can be justly mitigated by restricting emigration from sending countries or by limiting immigration opportunities to receiving countries. I raise moral and practical concerns against restricting the movement of skilled migrants and contend that conceptualizing the moral issue in these terms leads theorists to neglect the moral salience of institutions that determine the distributive effects of migration. Using an analogy to skilled migration in a domestic context, I argue for locating brain drain in a more holistic, institutional context that includes the reform of global institutions and of policies affecting migration.     

Accounting for Gender: the Role of the COAG Reform Council in Tracking Outcomes for Women and Girls Across Australia

The COAG Reform Council has played a critical role in tracking progress, nationally and on a state‐by‐state basis, against the COAG reform agenda. The council has analysed and publicly reported on governments’ performance against outcomes, performance indicators and targets agreed by COAG. However, until 2013 gender analysis was not directly incorporated in the assessment of governments’ performance. The council's first report on gender, Tracking equity: Comparing outcomes for women and girls across Australia, redressed this omission. This article explores how taking account of gender greatly enriches our understanding of governments’ performance in critical areas, and enhances public accountability as a result. An understanding of gender differences also provides a better basis for government decision‐making on ways to improve outcomes.     

Environment and climate mainstreaming: challenges and successes

This paper examines mainstreaming environment and climate change into development policy, planning, and budgeting. It looks at why we should integrate environment and climate and outlines challenges and successes. One result is that governments’ progress pro-poor and equitable development. Governance gains are important too: co-benefits include more transparent decision making and better cross-government working. Ultimately, the impact of mainstreaming has increased awareness, changed perceptions, and improved the way inter-sectoral decisions are made, especially in climate adaptation. This supports countries to achieve their sustainable development ambitions – lessons which could be applied to a post-2015 development agenda.     

Theory and Practice of Public Administration in the Philippines: Concerns for an Identity Crisis

Abstract

The discipline of public administration in the Philippines has been undergoing its version of an ‘identity crisis’ over the past decade. This crisis has been manifested in four areas: (1) the inordinate influence of mostly American public administration theories and concepts upon Philippines public administration has led Filipino academics in the early to mid-1980s to ask the question ‘is there a Philippine public administration?’; (2) the perceived disconnect between theories of public administration as taught in schools and the realities in the outside world has raised questions of the relevance of the discipline to real world challenges; (3) the continued frustration over the perception that in spite of many public administration and governance reforms, the Philippines continues to be among the more corrupt nations in the region; and (4) the recent fascination of academics in other disciplines, especially economists, that ‘institutions matter’, has led some public administration scholars to argue that their discipline has been arguing precisely the same point since the 1950s.     

The capacity building programme for english local government: Evaluating mechanisms for delivering improvement support to local authorities

The Capacity Building Programme for local government in England has employed a variety of different mechanisms to support local authority improvement. Like other central government initiatives to improve local government performance, the CBP has been the subject of evaluation of its progress. This article draws on the findings from the evaluation, to compare Direct Support and a series of National Programmes. It concludes by suggesting that the CBP's most recent changes herald an exciting new era for the CBP in which it might better develop the capacity of the ‘whole system’ of local governance and public service delivery to meet locally determined objectives.     

Fencing in Warfare: Threats,Punishment, and Intra-war Deterrence in Counterterrorism

New theoretical approaches have been developed that apply deterrence and coercion to counterterrorism. Critics have suggested, however, that in the particular case of deterring terrorism by threats of punishment, a mismatch exists between deterrent goals and counterterrorism intentions: the twin aims of destroying and deterring a single opponent is logically and theoretically incompatible. These criticisms, however, neglect to take two important factors into consideration. First, threats of punishment in counterterrorism can be applied against a wide assortment of actors involved in and associated with terrorism and political violence. Second, the concept of “intra-war deterrence” suggests ways in which a state can deter certain behavior or a specific form of warfare while engaging in open conflict with that same adversary. In exploring both factors, this article posits that states can gain coercive leverage over different actors involved in terrorism, including organizations with which they are actively hoping to defeat.     

Testing moffitt's neuropsychological variation hypothesis for the prediction of life-course persistent offending

Abstract

Although neuropsychological deficits have been linked to antisocial behavior, theories of crime have been slow to develop formal processes and predictions for neuropsychological deficits. One recently articulated theory, however, places emphasis on the influence of neuropsychological variation in the development of antisocial behavior. In her developmental taxonomy. Moffitt outlines a theory of antisocial behavior that rests on the presence of two groups of offenders: life-course persisters and adolescent-limiteds. Both groups occupy distinct etiologies for antisocial involvement and are believed to engage in different antisocial activities. One of the main differences between the two groups is the role that neuropsychological deficits play in the production of antisocial behavior. Moffitt hypothesizes that neuropsychological deficits are predictive of antisocial involvement for life-course persisters but not for adolescent-limiteds. Using data from the Philadelphia portion of the National Collaborative Perinatal Project, proxy measures of neuropsychological deficits are used to predict four different manifestations of life-course persistent offending. Results support Moffitt's hypothesis about the relationship between poor neuropsychological test scores and life-course persistent styles of offending.     

The subjectivist interpretation of probability and the problem of individualisation in forensic science

This paper presents and discusses further aspects of the subjectivist interpretation of probability (also known as the ‘personalist’ view of probabilities) as initiated in earlier forensic and legal literature. It shows that operational devices to elicit subjective probabilities – in particular the so-called scoring rules – provide additional arguments in support of the standpoint according to which categorical claims of forensic individualisation do not follow from a formal analysis under that view of probability theory.     

Integrating risk,the Good Lives Model and recovery for mentally disordered sexual offenders

Abstract

Personality disordered and mentally disordered sexual offenders (MDSOs) with complex diagnoses such as schizophrenia, developmental disorders and mood disorders face challenges of restoring their mental health, living more safely with personality- and offence-related risks, while addressing concerns about their capacity to reintegrate into society; this has been termed “secure recovery”. This paper reviews the literature on recovery, demonstrating its commonality with the Good Lives Model (GLM) as applied to MDSOs' offending treatment. GLM appears to provide a better fit with the recovery needs of MDSOs than the Risk–Need–Responsivity model because it emphasises approach goals, enhanced responsivity and skills acquisition. Recovery needs to integrate coping with mental disorders with risk management and a healthy, future lifestyle. Both secure recovery and GLM support the need for client–clinician collaboration, promoting self-determination and a shared narrative about coping with enduring risk and the hope of sustained well-being.