Patents with an "I" = patients

The authors address how patent protection in the United States is often quite narrow in scope, difficult to obtain, and insufficient in duration, thus stifling research and development of potential breakthrough pharmaceuticals. The authors further posit that countries that have enacted stronger intellectual property rights and research incentives have seen tremendous increases in foreign direct investment. In addressing critics of the current patent system, the authors show that alternatives to biotechnology patents would not demonstrably improve innovation and development of beneficial medicines. The authors conclude that given the substantial evidence of the patent system's benefits, and the mere speculation that patents have a deleterious effect on patients, no suggestions currently proposed to replace or improve the patent system will have the same beneficial effects for patients.     

The Rigor of Research Design and “Forensic” Publications in Neuropsychological Research

Seven neuropsychology journals that publish on topics relevant to clinical neuropsychology were examined for their experimental rigor according to the standards of the American Academy of Neurology (AAN) in their Clinical Practice Guidelines. By using a keyword approach on topics relevant to forensic neuropsychology, all articles that reported empirical findings from 2003 through 2008 were identified. Each study was rated by AAN classification criteria that ranged from a level I classification (prospective, most rigorous, and independent) to level IV (least rigorous). The typical forensic neuropsychological study averaged a class III ranking. Few studies were based on large sample sizes or utilized a reported masking or blind technique with regards to subject selection and how diagnostic criteria were met and/or data analyzed. While the authors for the average study reported a university affiliation, few reported explicit Institutional Review Board statements. Considerable variability across these seven journals with regards to conflict of interest (COI) disclosure policies was observed and only a few studies reported explicit statements about funding or COI issues. These observations suggest that neuropsychological research on forensic topics currently has many limitations and that future research needs to address these issues.     

How ‘Vulnerable’ young people describe their interactions with police: building positive pathways to drug diversion and treatment in Sydney and Melbourne,Australia

This article describes findings from an Australian mixed method study, and explores young people’s perceptions of police. We focus on the nature of positive experiences, and the potential for positive encounters to improve outcomes for young offenders affected by problematic alcohol and other drug use. Buber’s concept of dialogical interaction is used to articulate the components of a positive experience and how this increases police legitimacy. In doing so, we demonstrate that, despite negative experiences, young people can be sympathetic to the tensions of modern policing, and can envisage police as positive role models. As such, police can enhance outcomes for ‘vulnerable’ young people through more respectful interactions.     

Legal professionals’ knowledge and experience of autistic adults in the family justice system

Abstract

Access to justice is a key theme in the family justice system, especially for those with particular vulnerabilities. Autism, a development condition characterised by difficulties in social communication and interaction, and the presence of rigid, repetitive behaviours, presents particular challenges in this area. This paper reports the findings of a mixed-methods study with legal professionals working in the family justice system, asking about their knowledge of autism, their perceived self-efficacy when working with autistic clients, and their experience of cases involving autistic litigants. The study reports high levels of knowledge, but low levels of confidence, by legal professionals (N = 204), and addresses the experiences of particular cases in follow-up discussions (N = 10). The paper concludes by making a series of recommendations for legal professionals to assist autistic people to engage fully in family court proceedings.     

Comparing Experimental and Matching Methods Using a Large-Scale Voter Mobilization Experiment

Alan S. Gerber and Donald P. Green Yale University, Institution for Social and Policy Studies, P.O. Box 208209, 77 Prospect Street, New Haven, CT 06520 e-mail: kevin.arceneaux{at}temple.edu (corresponding author) e-mail: alan.gerber{at}yale.edu e-mail: donald.green{at}yale.edu In the social sciences, randomized experimentation is the optimalresearch design for establishing causation. However, for a numberof practical reasons, researchers are sometimes unable to conductexperiments and must rely on observational data. In an effortto develop estimators that can approximate experimental resultsusing observational data, scholars have given increasing attentionto matching. In this article, we test the performance of matchingby gauging the success with which matching approximates experimentalresults. The voter mobilization experiment presented here comprisesa large number of observations (60,000 randomly assigned tothe treatment group and nearly two million assigned to the controlgroup) and a rich set of covariates. This study is analyzedin two ways. The first method, instrumental variables estimation,takes advantage of random assignment in order to produce consistentestimates. The second method, matching estimation, ignores randomassignment and analyzes the data as though they were nonexperimental.Matching is found to produce biased results in this applicationbecause even a rich set of covariates is insufficient to controlfor preexisting differences between the treatment and controlgroup. Matching, in fact, produces estimates that are no moreaccurate than those generated by ordinary least squares regression.The experimental findings show that brief paid get-out-the-votephone calls do not increase turnout, while matching and regressionshow a large and significant effect.