Practical benzylation of N,N-substituted ethanolamines related to chemical warfare agents for analysis and detection by electron ionization gas chromatography–mass spectrometry

The benzylation of three low molecular weight N,N-disubstituted ethanolamines related to chemical warfare agents (CWAs) to furnish derivatives with improved gas chromatography-mass spectrometry (GC-MS) profiles is described. Due to their low molecular weight and polar nature, N,N-disubstituted ethanolamines are notoriously difficult to detect by routine GC-MS analyses during Organisation for the Prohibition of Chemical Weapons (OPCW) proficiency tests (PTs), particularly in scenarios when they are present at low levels (~1–10 ppm) amidst more abundant interferences. Our studies revealed that the optimal derivatization conditions involved the treatment of the ethanolamine with benzyl bromide in the presence of an inorganic base (e.g., Na₂CO₃) in dichloromethane at 55°C for 2 h. This optimized set of conditions was then successfully applied to the derivatization of N,N-dimethylethanolamine, N,N-diethylethanolamine and N,N-diisopropylethanolamine present separately at 1 and 10 μg/mL concentrations in a glycerol-rich matrix sample featured in the 48th OPCW PT. The benzylated derivatives of the three ethanolamines possessed retention times long enough to clear the massive glycerol-containing matrix interferences. The protocol herein is introduced as an alternative method for derivatization of these CWA and pharmaceutically important species and should find broad applicability in laboratories where routine forensic analysis is carried out.     

The effects of certain intermediary target materials and their proximity to ballistic gelatin on jacketed hollow point bullet expansion

Expanding bullets are preferred by law enforcement because of their wounding potential and ability to avoid over-penetration which could result in unintended targets being struck by bullets that perforate their intended targets. Expansion failure for jacketed hollow point (JHP) bullets is commonly attributed to several causes including damage to the bullet's cavity, velocity loss, bullet destabilization and materials from intermediate targets filling the bullet's cavity which can cause expansion failure when the bullet subsequently impacts a soft, fluid-based target such as human tissue or ballistic gelatin. In this study, JHP bullets were fired into ballistic gelatin after passing through selected intermediate targets representing items common to shooting incidents. Velocity loss and bullet destabilization were not factors that contributed to the JHP bullets that experienced expansion failure; however, materials obstructing the bullets' cavities and damage to the bullets' cavities were considered causes for some of the JHP bullet expansion failures. It was determined through this research that most of the target materials caused JHP bullet expansion failure when shored against the ballistic gelatin, but when placed at distances of 7 ft. from the ballistic gelatin, bullets fired through the same target materials did expand. This original and unique study produced findings that are of significant value to shooting incident reconstruction experts and other forensic professionals as shooting incidents can call into question a victim's proximity to a wall or door when a bullet(s) perforated such a target material.     

Anger Control and Acceptance of Violence as Mediators in the Relationship between Exposure to Interparental Conflict and Dating Violence Perpetration in Mexican Adolescents

Dating violence is a prevalent problem in high school students. Previous research has found that anger expression styles and acceptance of violence beliefs mediate the relationship between experiencing family violence and dating violence perpetration. Few studies have examined the intergenerational transmission of violence theory in predicting dating violence in Mexican teens. The purpose of this study is to examine the relationships among exposure to interparental violence, anger expression, acceptance of violence beliefs, and perpetration of teen dating violence in Mexican teens. Surveys were administered to 204 high school students (aged 15 to 17) from Monterrey, Mexico. Regression analyses revealed that anger control and acceptance of violence beliefs, mediated the relationship between interparental conflict and dating violence perpetration. These results support the use of family-based interventions that challenge acceptance of violence beliefs and teach anger control techniques in Mexican teens.     

Crisis,what crisis? A feminist analysis of discourse on masculinities and suicide

High male suicide rates are often constructed as evidence for an apparent ‘crisis of masculinity’. Conversely, ‘crisis of masculinity’ has been used to explain differential rates of male and female suicide in the UK (and elsewhere). We analyse three public cases where male suicide and ‘masculinity-crisis’ discourse are employed together. Our feminist analysis demonstrates that ‘crisis talk’ and male suicide are addressed in divergent ways. We therefore distinguish between ‘progressive’ and ‘conservative’ crisis narratives. Conservative narratives position high male suicide rates as a pernicious outcome of ‘threats’ to traditional gender roles and norms, suggesting the solution is to return to them. Contrastingly, progressive crisis accounts use male suicide to demonstrate that existing gender norms harm men as well as women and argue they should be altered to address male suicide. Conservative narratives often map on to anti-feminist politics, whereas progressive accounts reflect aspects of feminism. There is no neat feminist/anti-feminist distinction, however, as postfeminist ideas are also evident. We argue that, overall, each of the articulations of a ‘crisis of masculinity’ as evidenced by high rates of male suicide reinforces problematic gender politics. Further, in reifying simplistic, dualistic models of gender, they may ultimately constrain efforts to reduce suicide.     

Physiological Self-Regulation Buffers the Relationship between Impulsivity and Externalizing Behaviors among Nonclinical Adolescents

Trait impulsivity is a risk factor for rule breaking and aggressive (externalizing) behaviors among nonclinical youth. Buffers of trait-based risk are of practical interest to preventing externalizing behaviors. One such buffer may be the capacity and efforts of a child to self-regulate their physiology. Youth who possess baseline physiological self-regulatory capacities are more likely to maintain adaptive engagement with their environment and may be less prone to impulsively rule break or be aggressive. Similarly, youth who are able to use self-regulatory skills to calm their physiology in times of stress may be less likely to externalize distress. This study examined self-regulatory capacity and efforts as a moderator of the relationship between trait impulsivity and externalizing behaviors, cross-sectionally and prospectively. We hypothesized that the effect of trait impulsivity on externalizing behaviors would depend on the presence of baseline self-regulatory capacity and/or self-regulatory efforts during stress. Participants were 134 nonclinical adolescents (M_age?=?12.59, SD?=?1.20 51.9% female, 71% Caucasian). Trait impulsivity was measured using a parental report questionnaire. Physiological self-regulatory capacity and efforts were measured through collection of electrocardiogram data during a resting baseline and a stressful, unsolvable anagram task, respectively. Physiological self-regulation was quantified by calculating respiratory sinus arrhythmia scores across baseline and stress tasks. Respiratory sinus arrhythmia is the change in heart rate across the breathing cycle, and is hypothesized to index physiological self-regulation capacity and efforts under specific conditions. The results indicated that physiological self-regulation capacity, but not efforts, moderated the effect of trait impulsivity on externalizing behaviors prospectively. Stronger physiological self-regulatory capacity buffered the effect of greater trait impulsivity. Implications of these findings among typically developing youth are discussed.     

Patterns of Bullying and Sexual Harassment: Connections with Parents and Teachers as Direct Protective Factors

Involvement in bullying and sexual harassment in adolescence is associated with a variety of internalizing, externalizing, and health-risk behaviors. Yet, the two behaviors are often studied independently. The current study examined how bullying and sexual harassment co-occur and whether social connections protected youth from risk patterns. The data for this study come from the 2013 Minnesota Student Survey (N?=?121,311; 50% female, 74% White, 26% received free or reduced-price lunch; M _age?=?14.9, SD?=?1.3). Students reported on bullying and sexual harassment victimization and perpetration. Using latent class analysis, youth were classified into five patterns: High-Risk of All Forms of Victimization and Perpetration (7%), Relational and Cyberbullying Victimization (17%), Sexual Harassment Victimization and Perpetration (8%), Physical Bullying Perpetration (6%), and Low-Risk (62%). Compared to the low-risk class, the four other classes had lower levels of social connections, particularly with teachers and parents. Older youth (9th and 11th grade students) were at greater risk for the sexual harassment pattern, while younger youth (8th grade students) were at greater risk for bullying patterns. The results indicate that efforts to reduce bullying should also address sexual harassment and social connections with adults.