Expression of seminal vesicle-specific antigen in serum of lung tumor patients

Protein markers are commonly used in forensic medicine to establish the origin of human fluids detected in crime scenes. Semenogelins, the major protein constituents of semen coagulum, are the most effective markers for semen detection. Recently, it has been demonstrated that semenogelins are also ectopically expressed in small cell lung carcinomas (SCLC) and in a minority of non-small cell lung carcinomas (NSCLC). This finding prompted us to look for semenogelin expression in the serum of lung cancer patients. A set of 13 serum samples (3 from SCLC and 10 from NSCLC patients) was screened by enzyme-linked immunosorbent assay (ELISA), using a commercially available kit. Four of the NSCLC cases showed positive results. Ectopic expression of marker proteins in individuals affected by cancer could represent a potential source of forensic pitfalls.     

Sudden cardiac death and myocardial ischemia indicators: a comparative study of four immunohistochemical markers

The postmortem diagnosis of acute myocardial infarction represents a current challenge for forensic pathologists, particularly when death occurs within minutes to a few hours after the ischemic insult. Among the adult population the single most important cause of sudden cardiac death (SCD) is the well-known atherosclerotic coronary artery disease, commonly asymptomatic or unrecognized. The recognition of early myocardial damage using routine hematoxylin and eosin (H&E) staining is possible only if death has occurred at least 6 hours after the onset of the ischemic injury. The usefulness of immunohistochemical markers to the diagnosis of early myocardial damage has been recently suggested because most of them can be visible even serologically as early as few minutes after the beginning of the symptoms. To evaluate the usefulness of plasma and cellular antigens, their distribution patterns have been studied among a group of 18 SCD cases in which a myocardial ischemia was strongly suspected. For the present study, 4 markers have been selected on the basis of their different diagnostic potential as follows: among the plasma markers the C5b-9 and fibronectin, among the cellular markers the myoglobin and cardiac troponin. The results show that only the study of multiple markers such as those selected can provide enough evidence of myocardial ischemia and/or necrosis, supporting the final diagnosis of SCD. No single immunohistochemical staining is ideal for diagnosing early myocardial ischemia but a set of markers can improve the ability of forensic pathologists to detect ischemic areas when no macroscopic or microscopic evidence of necrosis is available. However, the interpretation of data obtained in each individual cannot be isolated from the overall assessment of the factors (cardiopulmonary resuscitation and/or agonal artifacts) that can affect the expression of each marker.     

Rupture of the spleen or splenic vessels (splenic emergency syndrome) in late pregnancy: a report of two autopsy cases

During the years 2004-2006, seven divers, who had deadly accidents, underwent post-mortem examination at the Institute of Legal Medicine of the University of Munich. The cause of death in all divers was drowning with typical pathomorphological findings. This should be regarded as separated to the triggering reason for drowning. The trigger for accident was established in four of seven cases by technical analysis and police investigation. High risk-taking, lack of technical service, and deficiency of dive equipment care were main reasons for death. We present two of these cases which showed several problems occurring concurrently. Autopsy always is necessary to look for indices for application of force or to exclude competitive reasons for death.     

Campus officers’ sanctioning of alcohol-involved crime: influences on discretionary decision-making

Universities are a hotbed of alcohol consumption, which is a major contributor to campus crime. In the US, campus police are responsible for handling crimes on campus. Like municipal police, campus officers are afforded the power to make discretionary sanctioning decisions. The question for this paper is what affects those decisions? To explore that topic, data collected during ride-alongs with campus officers are analyzed. Campus officers explained their sanctions as being affected by nine factors. The findings suggest that influences on campus and municipal officers’ sanctioning decisions are largely similar. The paper concludes by discussing implications for future research.     

Pathways to democratization in personalist dictatorships

Personalist dictatorships make up an increasingly large proportion of the world's dictatorships. Moreover, they tend to be particularly resistant to democratization. Understanding the conditions that increase the likelihood of democratic transitions in personalist contexts, therefore, is critical for the study and practice of democratization in the contemporary era. This study argues that political party creation is a key factor. Though personalist dictators typically create parties to offset immediate threats to their power posed by the elite – and particularly the military – doing so encourages peaceful mass mobilization and a realignment of elite networks. These dynamics, in turn, enhance prospects of democratization. Using cross-national empirical tests that address the potential endogeneity of this relationship, we find support for the argument that personalist dictators who create their own political party are more likely to democratize than those who ally with a pre-existing party or rule without one.     

The New Defenders of Human Rights? How Radical Right-Wing TNGOs are Using the Human Rights Discourse to Promote their Ideas

Generation Identity (GI) is at the centre of right-wing politics across Europe. Yet, it does not present itself as a right-wing organisation. In contrast, GI seeks to move from the margins into the centre of civil society. Based on the literature on transnational NGOs’ action repertoires and by situating the discourse of GI with respect to a traditional human rights TNGO, Amnesty International, my qualitative content analysis of the frames of both organisations shows that GI uses the vague language of human rights to formulate its radical right-wing positions in ways that sound familiar with accepted human rights claims. While using similar language, symbols, emotions and performances than Amnesty, GI at the same time promotes an exclusive understanding of human rights based on identity. This allows for a discretionary understanding and application of human rights and, hence, potentially challenges established human rights organisations such as Amnesty because the latter's ability to influence state actors relies on a powerful and strong transnational discourse of human rights as being non-negotiable, indivisible and non-transferable.     

The Role of Land Certification in Reducing Gaps in Productivity between Male- and Female-Owned Farms in Rural Ethiopia

This paper analyses the impact of a low-cost land certification programme on the productivity of female-headed households. The hypotheses tested in the paper emphasise on the interaction between the constraints that female-headed households face in terms of insecure land tenure, lack of productive resources and suboptimal land market participation, on the one hand, and the tenure security benefits of certification on the other. Our findings show that land certification has a positive effect on land market participation and productivity. Our analysis also suggests higher marginal effects of certification on female-headed households’ productivity, compared to the male ones.