An Isolated Perfused Rat Kidney Model for the Evaluation of the Effect of Glucose on Renal Tubular Epithelial Morphology

An isolated perfused kidney model was used to evaluate the effect of hyperglycemia on renal tubular epithelial cell morphology. Ten Sprague–Dawley rat kidneys were perfused with Krebs–Henseleit buffer containing 70 mmol/L of glucose (five for 1 h and five for 2 h). Two control groups consisted of 10 kidneys perfused with Krebs–Henseleit buffer without hyperglycemia (five for 1 h and five for 2 h), and 10 nonperfused contralateral kidneys placed in the same environment for the same duration. The hyperglycemia group had significantly increased renal tubular vacuolization (p < 0.001) compared to both control groups at 1 and 2 h. The isolated perfused kidney model recapitulates the renal tubular vacuolization phenotype found in hyperglycemia and may be a potential tool for the investigation into causal factors in renal histology. The full pattern of the Armanni–Ebstein phenomenon was not, however, reproduced, suggesting that this change requires more time or involves more complex factors.     

Blurring or Shifting of Policy Frames?: Institutionalization of the Economic-Environmental Policy Linkage in the European Community

This article investigates how "policy frames" have shaped the way European Community actors perceive the policy linkage between market integration and environmental policy. The article contends that there are three Community policy frames: conditional, classic, and sustainability. They form alternative "packages" of policy ideas defining the relationship between economic and environmental policy. The article provides an analysis of how actors embed these frames in the Community's institutional framework.To illustrate the general impact of policy frames on the environmental arena, the article explores two cases: waste management policy, and the integration of environmental concerns into the Community's agricultural policy. The article concludes by highlighting the different factors that promote and undermine the formation of "thick" institutional structures likely to integrate environmental and economic policy objectives.     

Exploring the psychological and somatic impact of identity theft

Identity theft is a new and growing form of white-collar crime. This exploratory study examined the psychological and somatic impact of identity theft and coping methods utilized by victims. Thirty-seven victims of identity theft participated in regional victim focus groups. Participants completed a victim impact questionnaire designed by the authors and the Brief Symptom Inventory-18 (BSI-18). The majority of participants expressed an increase in maladaptive psychological and somatic symptoms post victimization. Results on the BSI indicated that identity theft victims with unresolved cases, in contrast to those with resolved cases, were more likely to have clinically elevated scores when compared with a normative sample. Relatively similar coping mechanisms were utilized across victims. The results from this study suggest that victims of identity theft do have increased psychological and physical distress, and for those whose cases remain unresolved, distress is maintained over time.     

Validation of a large Italian Database of 15 STR loci

Results from a collaborative exercise with proficiency testing conducted by 20 Italian laboratories on the 15 loci included in the Identifiler kit were analyzed by allele sharing methods and by standard population genetics tests. The validated database, including about 1500 subjects, was merged with that of a previous exercise conducted on nine loci, and the resulting allele frequencies, subdivided by Italian region, were published on-line.     

LAP-banding obesity: a case of stomach perforation, peritonitis, and death

We present a case of peritonitis and death due to the misplacement of a laparoscopic adjustable band inserted through, instead of around, the stomach. This represents the first case in the published literature where a LAP-BAND perforated the stomach, followed by peritonitis and death. The morbidly obese female patient with a history of hypertension and arthritis was 47 years old, 5 feet 6 inches tall, weighed 361 pounds, and had a body mass index of 58.3. She underwent a 2-hour, elective, LAP-band insertion operation to achieve weight loss; 27 hours after band insertion, following the conduction of all FDA-mandated Lap-Band postoperative protocol (including a radiologic Gastrogrografin swallow), the patient was discharged with "no evidence of esophageal stasis or obstruction." She remained out of hospital care and in her residence until she called for and was taken by an ambulance to an alternate, local hospital (57 hours after band insertion), when gastric perforation was confirmed via x-ray and CT scans. No open surgery was attempted to repair the damage, and cardiac arrest ensued 7 hours after admission to the second hospital. The patient was pronounced dead 64 hours after LAP-band insertion. This unique case is significant, given that there were no deaths of this kind reported in The LAP-BAND(R) Adjustable Gastric Banding System Summary of Safety and Effectiveness Data by the United States Center for Devices and Radiologic Health, of the Food and Drug Administration, or in searches of the published literature.     

Population data for 12 Y-chromosome STRs in a sample from Brescia (northern Italy)

Twelve Y-chromosome STRs--DYS19, DYS389-I, DYS389-II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, DYS439--were typed in a population sample (n=104) of unrelated males from Brescia (northern Italy). A total of 91 haplotypes were identified by the 12 Y-STR loci. The haplotype diversity (98.68%), discrimination capacity (87.50%) and gene diversity were calculated.     

Geräusche von Freizeitanlagen

Nach Erfahrungen des Bayerischen Landesamtes für Umwelt treten in der Praxis Probleme bei der Abgrenzung von Freizeitanlagen gegenüber Sportanlagen auf. Seit Jahren gibt es keine eindeutige und abschließende Zuordnung, trotzdem existieren unterschiedliche Beurteilungsvorschriften. Zur schalltechnischen Beurteilung von Sportanlagen ist die 18. BImSchV (Sportanlagenlärmschutzverordnung) heranzuziehen. Zur schalltechnischen Beurteilung von Freizeitanlagen wird in vielen Bundesländern die vom Länderausschuss für Immissionsschutz erarbeitete Freizeitlärm-Richtlinie empfohlen oder vorgeschrieben. Sie weicht zwar, wie nachfolgende Gegenüberstellung aufzeigt, in Einzelpunkten von der 18. BImSchV deutlich ab. Ein Vergleich der nach beiden Vorschriften ermittelten Endergebnisse für ein und denselben Einzelfall führt aber unter Berücksichtigung aller Beurteilungskriterien oftmals zu einem unbedeutenden Unterschied. Dieser rechtfertigt es nicht, zwei unterschiedliche Vorschriften aufrecht zu erhalten.* Dipl.-Ing. (FH) Andrea Wellhöfer ist Mitarbeiterin im Referat Lärmschutz bei Anlagen und in der Planung des Bayerischen Landesamtes für Umwelt (bis 1. 8. 2005 Landesamt für Umweltschutz).