Statistical analysis of the measurement errors in the determination of fragment length in DNA-RFLP analysis.

DNA from human whole blood samples was digested with the restriction enzyme HinfI and RFLP analysis performed using the single locus probes MS1, MS31, MS43a and YNH24. The intergel variation of 3291 duplicate measurements of fragment lengths in terms of basepairs was investigated. The difference between two measurements of the same fragment on different gels increased approximately exponentially with increasing fragment length. After transformation of the fragment length into a normalized migration distance it was found that the difference between two transformed measurements was normally distributed with a S.D. (0.70 mm) which was independent of the fragment length. The errors of band 1 and band 2 on the same lane were correlated (r2 = 0.8). It is useful in the calculation of frequencies and in retrieval procedures and also in the calculation of likelihood ratios to be able to use a S.D. which is independent of the fragment length.     

Traumatic transection. An unusual fatal pedestrian injury.

Speed, alcohol, and pedestrian injuries constitute disturbing components of the spectrum of trauma in the developing world. The complete fatal transection of a pedestrian, at the level of the lower abdomen, by an oncoming automobile traveling at high speed is described. The upper torso was found inside the vehicle, whereas the lower torso was projected some distance ahead, onto the highway. An accident analysis, in order to ascertain the speed of the automobile, is demonstrated and the biodynamic mechanisms of this injury are discussed. The nature of this injury is compared with that of traumatic hemipelvectomy following which survival has been reported.     

Toxicological findings in military aircraft fatalities from 1986-1990.

Toxicological findings in all military aircraft fatalities investigated by the Division of Forensic Toxicology at the Armed Forces Institute of Pathology from 1986-1990 are presented. Carbon monoxide saturation levels greater than 10% were found in 4% of the 535 cases where appropriate specimens were collected. Positive ethanol findings were more indicative of postmortem formation than antemortem consumption. In only 1 case were abused drugs (cannabinoids in a passenger) detected. Other drugs identified included nicotine, chloroquine and over-the-counter analgesic agents, antihistamines and sympathomimetic drugs.     

GOVERNMENT PRODUCTIVITY, EFFECTIVENESS, AND PUBLIC POLICY

Marc Holzer and Stuart S. Nagel (editors) . 1984. Productivity and Public Policy .
George W. Downs and Patrick D. Larkey . 1986. The Search for Government Efficiency: From Hubris to Helplessness
Elaine Morley . 1986. A Practitioner's Guide to Public Sector Productivity Improvement .
Richard H. Silkman and Dennis R. Young with the assistance of Robert Lipp . 1985. Subsidizing Inefficiency: A Study of State Aid and Local Government Productivity .