The intersection of genes and neuropsychological deficits in the prediction of adolescent delinquency and low self-control

Gottfredson and Hirschi's A General Theory of Crime, Moffitt's developmental taxonomy theory, and Caspi et al.'s Gene x Environment study are three of the most influential pieces of contemporary criminological scholarship. Even so, there has been little attempt to integrate and empirically assess these three perspectives simultaneously. This article addresses this gap in the literature by analyzing phenotypic and genotypic data from the National Longitudinal Study of Adolescent Health (Add Health). The results revealed that all three perspectives have considerable empirical support, where neuropsychological deficits interact with the MAOA genotype to predict adolescent delinquency and levels of self-control for White males. The theoretical implications of the findings are noted.     

Cutting the Grass: A Reexamination of the Link between Marital Attachment,Delinquent Peers and Desistance from Marijuana Use

Recent work indicates that marriage contributes to desistance from crime. However, two prominent interpretations of this relationship have been offered. The first, rooted in informal control theory, suggests that the marriage effect is a direct result of social bonds that tend to accompany matrimony. The second contends that the effect is indirect and due to the impact of marriage on patterns of delinquent peer association. Using data from waves 5 and 6 of the National Youth Survey, this study re-analyzes these interpretations by examining the relationship between marital attachment, delinquent peer association and desistance from marijuana use. Although change in delinquent peer association is a powerful predictor of marijuana desistance, findings are also consistent with the control theory interpretation of the marriage effect. Implications and limitations of the current study are noted.A previous version of this paper was presented at the 2000 meeting of the American Society of Criminology in San Francisco, CA.     

Radiographic age estimation based on degenerative changes of vertebrae

Age estimation is an important component of decedent identification. When assessing adult remains, anthropologists frequently use gross examination of skeletal elements, such as clavicles, ribs, and pubic symphyses. For fleshed bodies, this requires the removal of these elements and maceration prior to analysis. A new method was developed using radiographic imaging to estimate age from degenerative changes of the lower thoracic and upper lumbar vertebrae. This technique will complement anthropological age estimation methods in young and middle-aged adults and may serve as a stand-alone method for older individuals. Digital radiographs from 240 medical examiner cases were evaluated. The sample included 120 females and 120 males between the ages of 18 and 101 years. A 3-phased scoring system was used for the target vertebrae. Transition analysis was conducted on binned average scores and a Bayesian approach was used to assign age intervals. At the 90% credible interval, individuals in Bin 1 were under 36 years of age while those in Bin 3 were over 47 years of age. Individuals in Bin 2 showed too much age variation to be informative. No significant differences were found between males and females. These findings will be especially useful in the age estimation of older adults and may eliminate the need for skeletal sampling in medicolegal cases where advanced degenerative changes are radiographically observed in the lower thoracic and/or upper lumbar vertebrae. This method was developed for use on fleshed individuals but may also be applicable to skeletonized remains.     

Field-portable detection of fentanyl and its analogs: A review

The need to detect fentanyl and its analogs in the field is an important capability to help prevent unintentional exposure or overdose on these substances, which may result in death. Many portable methods historically used in the field by first responders and other field users to detect and identify other chemical substances, such as hazardous materials, have been applied to the detection and identification of these synthetic opioids. This paper describes field portable spectroscopic methods used for the detection and identification of fentanyl and its analogs. The methods described are automated colorimetric tests including lateral flow assays; vibrational spectroscopy (mid-infrared and Raman); gas chromatography–mass spectrometry; ion mobility spectrometry, and high-pressure mass spectrometry. In each case the background and key details of these technologies are outlined, followed by a discussion of the application of the technology in the field. Attention is paid to the analysis of complex mixtures and limits of detection, including the required spectral databases and algorithms used to interrogate these types of samples. There is also an emphasis on providing actionable information to the (likely) non-scientist operators of these instruments in the field.     

Rapid enantiomeric analysis of zopiclone in serum by supercritical fluid chromatography–tandem mass spectrometry

Zopiclone (ZOP) is a hypnotic drug prescribed to treat insomnia. Due to the chiral nature of ZOP, the psychologically active S-form and inactive R-form need to be determined enantiomerically in a forensic drug analysis. In the present study, a supercritical fluid chromatography (SFC) method was designed with a faster analysis ability than that of previously reported techniques. The SFC–tandem mass spectrometry (SFC–MS/MS) method was optimized using a column with a chiral polysaccharide stationary phase (Trefoil CEL2). ZOP was extracted from pooled human serum using solid-phase extraction (Oasis HLB) and analyzed. The developed SFC–MS/MS method achieved the baseline separation of S-ZOP and R-ZOP within 2 min. The fit-for-purpose method validation indicated that the optimized solid-phase extraction achieved near complete recovery and approximately 70% of the matrix effect. Both the retention time and peak area showed sufficient precision. The lower and upper limits of quantification (LOQ) were 5.7 × 10⁻² ng/mL and 25 ng/mL for R-ZOP, and 5.2 × 10⁻² ng/mL and 25 ng/mL for S-ZOP. The calibration line was linear in the range from lower LOQ to upper LOQ. The stability test indicated that ZOP in serum stored in a refrigerator (4°C) degraded and about 55% remained in 31 days. The quick analysis of the SFC–MS/MS method makes it a valid option for the enantiomeric analysis of ZOP.     

Genetic risk factors correlate with county-level violent crime rates and collective disadvantage

Purpose

Social scientists have a rich tradition of uncovering the neighborhood, structural, and ecological correlates of human behavior. Results from this body of evidence have revealed that living in disadvantaged communities portends myriad negative outcomes, including antisocial behaviors. Though it has long been argued that associations between neighborhood factors and individual-level outcomes may, at least partially, reflect genetic selection, a paucity of research has empirically investigated this possibility.

Methods

The current study examined whether known genetic risk factors for antisocial behavior were predictive of exposure to disadvantage and violent crime measured at the county level. Drawing on genotypic data from the National Longitudinal Study of Adolescent Health, a dopamine risk scale was created based on respondents’ genotypes for DAT1, DRD2, and DRD4. County-level disadvantage was measured via Census data and violent crime rates were measured via the FBI’s Uniform Crime Reports.

Results

Findings revealed that individuals with a greater number of dopamine risk alleles were more likely to live in a disadvantaged county and were more likely to live in a county with higher violent crime rates.     

The Relationship between Self-Control in Adolescence and Social Consequences in Adulthood: Assessing the Influence of Genetic Confounds

Purpose

Assess the relationship between levels of self-control in adolescence and a variety of later-life outcomes and evaluate the confounding effects of genetic factors.

Methods

The current study employed data from the National Longitudinal Study of Adolescent Health (Add Health) and examined whether levels of self-control in adolescence are related to economic, educational, employment, health, relationship and family, and behavioral outcomes in adulthood using DeFries-Fulker regression-based analyses.

Results

Analyses employing non-genetically sensitive methods indicated robust associations between self-control and various social consequences. After estimating genetically-sensitive analyses, however, many associations were no longer significant. Those associations which remained significant were in the reversed direction relative to the non-genetically sensitive models. Additionally, further analyses indicated that some of the remaining significant associations were influenced by nonshared genetic effects.

Conclusions

The findings indicate that even after controlling for the effect of genetic factors, levels of self-control are associated with differences in a variety of social outcomes. However, given the reduction in the number of significant associations and reversal of associations in the genetically sensitive models, analyses of the social consequences of low self-control which do not account for the effect of genetic factors are likely misspecified.