High thyroglobulin (Tg) concentrations in fatal traumatic brain injuries

It is well known that under physiological conditions, the Tg molecule is the substrate for the hormones triiodothyronine and thyroxine. Its function outside the thyroid gland is unknown. Under certain pathologic conditions, an increase in Tg concentrations in the blood can occur, a phenomenon that is used in the clinical diagnosis of certain thyroid disorders. However, fatal traumatic brain injuries (TBI) can also produce a raised Tg concentration in blood. In such cases, mean (n=151) Tg concentrations of 405.8+/-353.3 ng/mL have been observed, with the values in 57% of these cases exceeding 200 ng/mL. Since it was possible to rule out specifically any thyroid disorders in these cases, the raised values may be explained by the effect of TSH in the spectrum of the "hypothalamic-pituitary-thyroid axis." This assumption has been substantiated by immunohistochemical tests for TSH and Tg. Compared with the controls (sudden unnatural deaths: Tg 23.3+/-27.6 ng/mL), the raised Tg values in the TBI cases were usually accompanied by a reduction in the intensity of immunohistochemical reactions relating to TSH and Tg. The hypophysis showed evidence of significant damage with morphologic changes such as edema, hemorrhages, and focal necrosis in association with reduced TSH levels.     

Business Angel and risk capital： The impact on innovation

The aim of the analysis is to understand if the risk capital carried by Business Angels （B.A.） could affect firms with high innovation propensity in creating more innovations than receiving risk capital from other financial operators. Innovation is a critical factor for the competitiveness of national system especially when the economy of the latter has come to maturity. For realizing ＂the successful exploitation of ideas, into new products, processes, services or business practices, and the critical process for achieving two complementary business goals of performance and growth, which in turn will help to close the productivity gap＂ （DTI＇s Innovation Report, 2003, p. 8）, firms have to understand which are the right competences to increase. In this context, the authors have developed a framework that measures the propensity to innovate in the firms. The model considers the firm＇s competences （grouped into four macro areas as management, organization, ITC and marketing） to improve the creation, development and diffusion of the innovation. The work is structured as an empirical analysis as follows： （1） The authors analyzed a sample of 12 business plans （choices for high level of innovation in their business） that received risk capital from B.A. and other financial operators; （2） For each firm, their innovation propensity is measured through the author＇s model during their start-up period （the data analyzed are business plan＇s data）; （3） After a period of time （3 years）, the authors checked if the firms with high innovation propensity have created real innovation and if a correlation exists between risk capital origin （from Business Angels or not） and innovation propensity. The conclusion of the work is the finns with B.A.＇s risk capital have a high innovation propensity and create after a medium term period more innovation compared with the others.     

Democracy Beyond Secrecy: Assessing the Promises and Pitfalls of Collective Voting

This paper assesses collective voting as a specific mode of democratic decision‐making and compares it to secret voting. Under collective voting, voters gather in one place and decide by the show of hands. We theorise two potential advantages and two disadvantages of collective voting so defined. We then draw on original survey data from one of the largest polities practising collective voting, the citizen assembly of the Swiss canton of Glarus. We find that both the promises and pitfalls of non‐secret voting are exaggerated. Non‐secret voting’s suspected pitfalls – social pressure and abstention – do not generally materialise in our sample, although for women they do appear to be relevant to some extent. However, the promises of collective voting – enabling cue‐taking and discursive bridging and bonding – are equally realised to a limited extent only.     

Understanding Entrepreneurial Intent in Late Adolescence: The Role of Intentional Self-Regulation and Innovation

Entrepreneurship represents a form of adaptive developmental regulation through which both entrepreneurs and their ecologies benefit. We describe entrepreneurship from the perspective of relational developmental systems theory, and examine the joint role of personal attributes, contextual attributes, and characteristics of person-context relationships in predicting entrepreneurial intent in a sample 3,461 college students enrolled in colleges and universities in the United States (60 % female; 61 % European American). Specifically, we tested whether personal characteristics (i.e., gender, intentional self-regulation skills, innovation orientation) and contextual factors (i.e., entrepreneurial parents) predicted college students’ intentions to pursue an entrepreneurial career. Our findings suggest that self-regulation, innovation orientation, and having entrepreneurial role models (i.e., parents) predict entrepreneurial intent. Limitations and future directions for the study of youth entrepreneurship are discussed.     

Activity Involvement as an Ecological Asset: Profiles of Participation and Youth Outcomes

Prior research has demonstrated that participation in out-of-school time activities is associated with positive and healthy development among adolescents. However, fewer studies have examined how trajectories of participation across multiple activities can impact developmental outcomes. Using data from Wave 3 (approximately Grade 7) through Wave 8 (approximately Grade 12) of the 4-H Study of Positive Youth Development, this study examined patterns of breadth in out-of-school time participation in activities and associated outcomes in positive youth development (PYD), Contribution to self and community, risk behaviors, and depressive symptoms. We assessed 927 students (on average across waves, 65.4 % female) from a relatively racially and ethnically homogeneous sample (about 74 % European American, across waves) with a mean age in Wave 3 of 12.98 years (SD = 0.52). The results indicated that high likelihood of participation in activities was consistently associated with fewer negative outcomes and higher scores on PYD and Contribution, as compared to low likelihood of participation in activities. Changes in the breadth of participation (in particular, moving from a high to a low likelihood of participation) were associated with increased substance use, depressive symptoms, and risk behaviors. Limitations of the current study, implications for future research, and applications to youth programs are discussed.     

The Evolution of Political Violence: The Case of Somalia’s Al-Shabaab

This research investigates the development and expansion of the al-Shabaab movement in Somalia from 2000 to 2013. Initially a marginal player in Somalia, by 2013 al-Shabaab had transformed into the most formidable armed opposition to challenge the nascent Somali government and its allies. During this time period they administered territory domestically, while expanding their tactical repertoire and geographic scope of attacks. After analyzing the historical conditions (2000–2006) from which al-Shabaab emerged, I explore the evolution of this organization through the use of historical process tracing. This entails looking for critical junctures on a global, national, and local level that had a dramatic impact on the future trajectory of the insurgency. The results show that harsh foreign interventions had many deleterious consequences, acting as an initial impetus for armed resistance, while also acting as a continuous source of controversy which al-Shabaab exploited to gain new recruits. Moreover, irreconcilable intra-organizational schisms also contributed to altering the future organizational decisions made by al-Shabaab. The culmination of these results engage and expand the theory of categorical terrorism, offering observations to help scholars and policy makers alike begin to re-conceptualize ways to study terrorism and political violence.     

The purpose of intergovernmental councils: A framework for analysis and comparison

ABSTRACT

Intergovernmental councils (IGCs) are specific, institutionalized forums of intergovernmental relations. They provide essential horizontal and/or vertical executive channels for preparing, deciding, and implementing multilevel policies. We assume there to be variation, both across federal systems and policy domains, in the purpose they serve – from mutual influence and protection of autonomy through joint decision-making to mere exchange of information – the use that central or sub-state actors make of IGCs, as well as their effectivity. In order to map and explain such variation, this introductory article provides a framework for analysis that includes both conceptual building blocks and conjectural relationships, laying the comparative groundwork for the case studies included in this Special Issue. Findings from the case studies indicate that it is primarily the institutional architecture, but also the structure of the multilevel party system, that account for variation in the purpose and effectiveness of IGCs.     

Vertical influence or horizontal coordination? The purpose of intergovernmental councils in Switzerland

ABSTRACT

In 1993, the Swiss cantons established the conference of cantonal governments (KdK). While the literature on Swiss federalism generally acknowledges the important role of the KdK, little is known about its specific purpose, in particular compared to other, older intergovernmental councils operating in Switzerland. We therefore investigate the purpose of the KdK and contrast it with two other intercantonal conferences with nationwide scope, namely those on education and finance. To do so, we trace two of the most important federal reform processes of the last decade: the latest renewal of fiscal equalization and educational harmonization. We find a division of labour between the KdK and policy-specific councils. While the former aims at vertical political influence, the latter primarily engage in genuine horizontal policy coordination. This flexible and smooth interplay of the two types of councils has contributed to further strengthening the political role of the cantons in the Swiss federation.     

Fairtrade and Labour Markets in Ethiopia and Uganda

Drawing on four years of fieldwork in Ethiopia and Uganda, this paper addresses gaps in knowledge about the mechanisms linking agricultural exports with poverty reduction, the functioning of rural labour markets, and the relevance to the lives of the poorest people of Fairtrade. Statistical analysis of survey evidence, complemented by qualitative research, highlights the relatively poor payment and non-pay working conditions of those employed in research sites dominated by Fairtrade producer organisations. We conclude that Fairtrade is not an effective way to improve the welfare of the poorest rural people.