The identification of 2-chloro-4,5-methylenedioxymethylamphetamine in an illicit drug seizure

This work outlines the unequivocal identification of the "ecstasy" analog, 2-chloro-4,5-methylenedioxymethylamphetamine, using combined gas chromatography/mass spectroscopy (GC/MS) and proton magnetic resonance spectroscopy (1H-NMR). This compound was identified along with 3,4-methylenedioxymethylamphetamine (MDMA) in an illicit tablet seizure, which included 26 off-white tablets.     

The determination of psilocin and psilocybin in hallucinogenic mushrooms by HPLC utilizing a dual reagent acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection system

This paper describes a procedure for the determination of psilocin and psilocybin in mushroom extracts using high-performance liquid chromatography with postcolumn chemiluminescence detection. A number of extraction methods for psilocin and psilocybin in hallucinogenic mushrooms were investigated, with a simple methanolic extraction being found to be most effective. Psilocin and psilocybin were extracted from a variety of hallucinogenic mushrooms using methanol. The analytes were separated on a C12 column using a (95:5% v/v) methanol:10 mM ammonium formate, pH 3.5 mobile phase with a run time of 5 min. Detection was realized through a dual reagent chemiluminescence detection system of acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II). The chemiluminescence detection system gave improved detectability when compared with UV absorption at 269 nm, with detection limits of 1.2 x 10(-8) and 3.5 x 10(-9) mol/L being obtained for psilocin and psilocybin, respectively. The procedure was applied to the determination of psilocin and psilocybin in three Australian species of hallucinogenic mushroom.     

Self-control, Victimization, and their Influence on Risky Lifestyles: A Longitudinal Analysis Using Panel Data

This research expands past investigations into the influence of low self-control as a risk factor for criminal victimization. Specifically, we consider two questions: (1) whether low self-control at one point in time can predict future victimization, and (2) whether victims alter lifestyle choices (like their own delinquency and contact with delinquent peers) in response to their earlier victimization. We answered these questions using three waves of adolescent panel data from the evaluation of the Gang Resistance Education and Training program. Our results support the predictions of self-control theory, showing that low self-control measured at an earlier time is associated with later victimization, even after controlling for past victimization, delinquency, social bonds, and delinquent peer contact. Likewise, self-control appears to influence the relationship between earlier victimization and later lifestyles.

Repartnering and the Management of Risk

Social theorists working with concept of ‘risk society’have addressed the issue of family change, suggesting that processesof individualization mean that family relationships have become‘elective’, which has in turn raised questions aboutthe nature of trust and commitment in intimate relationships.The position of those who are repartnering is particularly sensitivein these respects. Their awareness of risks may render themmore likely to make only contingent commitments, or may makethem more anxious to achieve a relationship founded on trustand commitment. We draw on in-depth interviews with a representativesample of people in England who have repartnered from a varietyof types of intimate relationship into different statuses inorder to explore the management of perceived risks. We findthat for most respondents repartnering is a process involvingdifferent kinds of relationships, although living-apart-togetheris understood as something rather different. There is littlesupport for the risk society thesis in respect of intimate relationshipsin respect of rejection of commitment and absence of trust.Rather, changes in relationship status often seem to be partof the process of building trust and of achieving the goal ofa rather traditional relationship. This poses challenges forpolicymakers as they seek to regulate different statuses indifferent ways.     

Development of a human-specific real-time PCR assay for the simultaneous quantitation of total genomic and male DNA

A duplex real-time quantitative PCR assay was developed for forensic DNA analysis, which provides simultaneous quantitation of total genomic human DNA and human male DNA. The assay utilizes two spectrally resolved fluorogenic probes in a 5' nuclease (TaqMantrade mark) assay. Within the range of organisms empirically tested and based upon theoretical specificity using National Center for Biotechnology Information GenBank sequences, primer and probe sequences were shown to be human specific, and the Y-chromosome probe, male-specific. A mixture-challenge study resulted in accurate quantitation of 25 pg male DNA in a mixture of up to 1:5000 (male:female DNA). Additional experimental results include comparisons with the slot blot method and commercial real-time PCR kits. The assay developed addresses the shortcomings of the traditional slot blot method as well as the commercial real-time PCR kits. This method is shown to be specific, relatively simple, rapid, has low limits of detection, and consumes limited sample in addition to reporting both the male and total genomic DNA concentrations present.     

Postbariatric surgery deaths, which fall under the jurisdiction of the coroner

Obesity has attained epidemic proportions in the United States, with more than 50% of adults classified as overweight or obese. If untreated, morbidly obese patients have a 1 in 7 chance of reaching normal life expectancy. The surgical treatment of obesity has emerged as the most effective treatment modality in long-term weight control and has become increasingly popular, with attendant postoperative complications and death. We performed a cross-sectional, coroner based, 2-year retrospective review of archival case records for decedents who died following bariatric surgery for the treatment of obesity to identify underlying causes of death and forensic characteristics of this cohort. Fifteen (0.5%) out of 3097 archival cases died following bariatric surgery, with approximately 73% of decedents dying within 6 months of surgery. The underlying causes of death in 80% of decedents were natural comorbidities of obesity, with cardiovascular diseases (33%) being the most frequent causes of death, followed by gastrointestinal diseases (20%), acute pulmonary thromboembolism (13%), and acute bacterial pneumonia (13%). The majority of decedents were white females who remained morbidly obese after bariatric surgery. Only 2 decedents died of direct inadvertent/accidental surgical complications.     

Political Learning from Rare Events: Poisson Inference, Fiscal Constraints, and the Lifetime of Bureaus

David E. Lewis Woodrow Wilson School and Department of Politics, Princeton University, Princeton, NJ 08544 e-mail: delewis{at}princeton.edu How do political actors learn about their environment when the"data" provided by political processes are characterized byrare events and highly discontinuous variation? In such learningenvironments, what can theory predict about how learning actorswill take costly actions that are difficult to reverse (e.g.,eliminating programs, approving a risky new product, revisinga security policy, firing or recalling an appointed or electedofficial)? We develop a formal model for this problem and applyit to the termination of bureaucratic agencies. The conventionalwisdom that "the older a bureau is, the less likely it is todie" (Downs 1967, Inside Bureaucracy) persists but has neverbeen properly tested. This paper offers a learning-based stochasticoptimization model of agency termination that offers two counterintuitivepredictions. First, politicians terminate agencies only afterlearning about them, so the hazard of agencies should be nonmonotonic,contradicting Downs's prediction. Second, if terminating agenciesis costly, agencies are least likely to be terminated when politiciansare fiscally constrained or when the deficit is high. We assessthe model by developing a battery of tests for the shape ofthe hazard function and estimate these and other duration modelsusing data on U.S. federal government agencies created between1946 and 1997. Results show that the hazard rate of agency terminationis strongly nonmonotonic and that agencies are less likely tobe terminated under high deficits and divided government. Forthe first 50 years of the agency duration distribution, themodal termination hazard occurs at five years after agenciesare enabled. Methodologically, our approach ties the functionalform of a hazard model tightly to theory and presents an applied"agenda" for testing the shape of an empirical hazard function.With extensions, our model and empirical framework are applicableto a range of political phenomena.