Sudden infant death and liver phosphoenolpyruvate carboxykinase analysis

In an effort to substantiate the impaired gluconeogenesis-terminal hypoglycemia hypothesis of sudden infant death syndrome (SIDS), 52 infants ranging from 3 weeks to 7 months of age which had been brought to autopsy were studied. The stomach contents, vitreous humor glucose concentrations, hepatic glycogen content and hepatic phospho-enolpyruvate carboxykinase (PEPCK) activity were measured as part of the laboratory component of the postmortem investigation. The stomach contents, vitreous humor glucose concentrations and liver glycogen content were similar in SIDS/and non-SIDS victims. PEPCK activity was, however, significantly lower in SIDS (p < 0.001) victims and in SIDS with other findings (p < 0.01) victims when compared to non-SIDS victims. Despite the fact that SIDS victims had lower hepatic PEPCK activity and hence potentially lower gluconeogenic capacity, terminal hypoglycemia could not be demonstrated in this group as compared to the SIDS with other findings and the non-SIDS infants. The impaired gluconeogenesis-terminal hypoglycemia hypothesis thus could not be substantiated.     

Dynamic Pie: A Strategy for Modeling Trade‐Offs in Compositional Variables over Time

The substance of politics involves competition that evolves over time. While our theories about competition emphasize trade‐offs across multiple categories, most empirical models tend to oversimplify them by considering trade‐offs between one category and everything else. We propose a research strategy for testing theories about trade‐off relationships that shape dynamic compositional variables. This approach improves current methods used to analyze compositional dependent variables by addressing two limitations. First, although scholars have considered compositional dependent variables, they have done so in contexts that were not dynamic. Second, current approaches toward graphical presentations become unwieldy when the compositional dependent variable has more than three categories. We demonstrate the utility of our strategy to expand current theories of party support and political budgeting. In both cases, we can extend trade‐offs across pairs of alternatives (e.g., prime minister versus all other parties or spending on defense versus everything else) to competition across multiple alternatives.     

The Domestic Use of Drones: An Ethical Analysis of Surveillance Issues

Drone surveillance can be regarded either as a justifiable, impartial practice serving the interests of all or as an oppressive technique catering to the interests of some at the expense of others. This analysis is an effort to weigh the ethical prospects and problems in the use of unmanned aerial vehicles by asking whether surveillance of civilians is ethical. To address this question, classical philosophical and modern behavioral approaches to ethics are used. The inquiry begins with the importance of the issue, followed by its evolution and current status. After describing the method of analysis, the article examines arguments for and against domestic monitoring. The unique utility of drones can accomplish much in the public interest while simultaneously creating moral hazards. The conclusion discusses accountability standards, model legislation provisions, and regulatory criteria for aerial vehicle surveillance.     

Legal reforms appropriate for cohabitants and LATs

Cohabitants and LATs (couples who “live apart together”) do not fit the traditional categories and rules of our family law system. This article describes what we know about both cohabitants and LATs in the U.S., compares the two institutions, and makes recommendations about legal reforms with respect to each. For cohabitants the reforms would assimilate cohabiting couples to marriage after the passage of time, based on the evidence of their economic interdependence and the probability that there are children in their households. As to LATs, the reforms proposed are limited to those that would support the caretaking functions LATs perform for each other, resulting in benefits to society as a whole.     

How to Cautiously Uncover the “Black Box” of Machine Learning Models for Legislative Scholars

Machine learning models, especially ensemble and tree-based approaches, offer great promise to legislative scholars. However, they are heavily underutilized outside of narrow applications to text and networks. We believe this is because they are difficult to interpret: while the models are extremely flexible, they have been criticized as “black box” techniques due to their difficulty in visualizing the effect of predictors on the outcome of interest. In order to make these models more useful for legislative scholars, we introduce a framework integrating machine learning models with traditional parametric approaches. We then review three interpretative plotting strategies that scholars can use to bring a substantive interpretation to their machine learning models. For each, we explain the plotting strategy, when to use it, and how to interpret it. We then put these plots in action by revisiting two recent articles from Legislative Studies Quarterly.     

Postmortem serum uric acid and creatinine levels in relation to the causes of death

Serum uric acid (UA) and creatinine (Cr) mainly derive from skeletal muscle tissues. Although, remarkable postmortem stability of the serum levels has been reported, there appears to be very poor knowledge of the diagnostic value in investigation of death, except for uremia. The aim of the present study was to evaluate postmortem serum UA and Cr levels using 395 forensic autopsy cases, in comparison with blood urea nitrogen (BUN), for investigation of the pathophysiology of death with special regard to the causes of death involving possible skeletal muscle damage, e.g. due to hypoxia, heat or agonal convulsions. Cr and BUN showed relatively good topographic stability in the cadaveric blood, whereas, UA was often much higher in the right heart blood than in the left heart and peripheral blood, independent of postmortem intervals. Moderate to marked elevation of Cr and BUN accompanied with hyperuricemia was observed in delayed death. In the acute death cases (survival time <30 min), UA, especially in the right heart blood, showed a considerable elevation in mechanical asphyxiation and drowning. The Cr level in fire victims with a lower carboxyhemoglobin (COHb) level (<60%) was significantly higher than in those with the possible fatal level (>60%). A similar elevation of Cr was observed in fatalities from heat stroke and methamphetamine (MA) poisoning. The observations suggested that hyperuricemia in acute death may be indicative of advanced hypoxia and that elevated Cr level may reflect the skeletal muscle damage, especially due to thermal influence.     

The Role of FDI,Exports and Spillover Effects in the Regional Development of China

The objective of this analysis is to assess the impacts of export expansion, inward FDI, domestic investment and labour on the growth of China's Eastern, Central and Western regions using panel data over the period 1984 to 1998. A major contribution of the study is its tests for the presence of interregional spillover effects. The study indicates that both inward FDI and domestic investment stimulate growth in all three regions and for the PRC as a whole and that export expansion stimulates the growth of the PRC, Eastern and Central China, but not the West. Labour enhances the growth of the more traditional Western region, but not the more capital intensive Eastern seaboard or the PRC in its entirety. Finally, output growth spills over from the East to Western and Central China and from the Central area to Western China. These results are fully explained in the text.     

Crimes Against Caring: Exploring the Risk of Secondary Traumatic Stress,Burnout, and Compassion Satisfaction Among Child Exploitation Investigators

Secondary traumatic stress (STS) and burnout are debilitating occupational hazards that inhibit helping professional’s overall well-being. Much of the extant scholarship on this topic has focused on mental health and child welfare workers and not law enforcement officials who investigate Internet child exploitation. This study used data from 433 Internet Crimes Against Children (ICAC) Task Force personnel to explore the impact of individual and work-related factors associated with the risk of STS, burnout, and compassion satisfaction. Findings indicated that nearly one in four ICAC personnel exhibited low compassion satisfaction and high levels of STS and burnout. Individual-level protective factors for increasing compassion satisfaction and mitigating symptoms of STS and burnout included having a strong social support system outside of work and the frequent use of positive coping mechanisms. Work-related risk factors such as frequent indirect exposure to disturbing materials, low organizational support, and frequently feeling overwhelmed at work were all associated with higher STS and burnout and lower levels of compassion satisfaction. Policy implications and future avenues of research are discussed.     

The Impact of Acceptance and Commitment Therapy on Positive Parenting Strategies Among Parents Who Have Experienced Relationship Violence

Evidence supports the use of acceptance and commitment therapy (ACT) for well-being and behavior change among parents. This study examined the impact of a brief ACT intervention on positive parenting strategies, psychological flexibility, and distress among parents who have experienced relationship violence.As part of a larger study, 43 parents were recruited from a community outreach center and completed measures of parenting, ACT processes, and distress. Participants were pseudo-randomly assigned to either receive their treatment-as-usual (TAU) or ACT plus TAU. Twenty-five participants received four weekly sessions of ACT plus TAU, and 18 received TAU only. Positive parenting behaviors among parents in the ACT?+?TAU group improved immediately following treatment compared to the TAU group. Improvements were maintained six weeks following treatment. The hypothesis that psychological flexibility would mediate improvements was not supported.The present study provides initial, preliminary support for the secondary benefits of brief, broad ACT interventions for positive parenting behaviors among parents who have experienced relationship violence. Clinical implications for implementing ACT for parents who have experienced relationship violence and methodological limitations are discussed.     

Counting on codes: An examination of transnational codes as a regulatory governance mechanism for nanotechnologies

This article examines the rise of nanotechnology‐specific codes of conduct (nano‐codes) as a private governance mechanism to manage potential risks and promote the technology. It examines their effectiveness as well as their legitimacy as regulatory instruments in the public domain. The study first maps the rise of voluntary nano‐codes and the roles played by different actors. Focusing on five specific nano‐codes, the article then discusses their adequacy in terms of scientific uncertainty, gaps in existing regulatory regimes, and broader societal concerns. It concludes that these voluntary nano‐codes have weaknesses including a lack of explicit standards on which to base independent monitoring, as well as no sanctions for poor compliance. At the same time it also highlights the potential power of these governance mechanisms under conditions of uncertainty and co‐regulation with government. It is likely that nano‐codes will become the “first cut” of a new governance regime for nanotechnologies.