Cocaine fatality: an unexplained blood concentration in a fatal overdose

A case is presented of a 26-year-old female who died as a result of cocaine intoxication. A blood cocaine concentration of 330 mg/l, about 1.5 times greater than the highest concentration previously reported, was found. Blood benzoylecgonine and ecgonine methyl ester concentrations were 50 and 18 mg/l, respectively. The unusually high blood concentrations of cocaine and the metabolites are suggestive of a massive administration, however, the history suggests a series of recreational uses. The manner of death was undetermined.     

A fentanyl fatality involving midazolam

A case is presented of a 35-year-old black African male anesthesiology resident, found dead in his apartment. At the scene a syringe, butterfly intravenous line and a bottle of Versed (Midazolam) were recovered. A comprehensive screen for common drugs of abuse and therapeutic agents failed to detect any drugs in blood and urine. The blood ethanol concentration was 0.06 g/dl. A GC/MS SIM assay for midazolam was developed. A sub-therapeutic midazolam blood concentration of 7.5 ng/ml was detected and concentrations (ng/ml or ng/g) in bile, urine, and liver were 3.3, 7.5, and 96, respectively. The syringe fluid was then analyzed and found to contain only fentanyl, midazolam was absent. The blood fentanyl concentration was 4.9 ng/ml which is consistent with those reported in fentanyl fatalities. Fentanyl concentrations (ng/ml or ng/g) in bile, urine, and liver were 8.8, 5.0, and 5.9, respectively. The cause of death was ruled to be fentanyl intoxication and the manner of death undetermined.     

Bupropion and alcohol fatal intoxication: case report.

A fatality due to the ingestion of bupropion and ethanol is presented. Bupropion and its metabolites were extracted from several tissues and identified using gas chromatography with nitrogenphosphorus and mass spectrometry detection. The concentrations of bupropion, hydroxybupropion and the erythroamino and threoamino alcohol metabolites in heart blood were 4.2, 5.0, 0.6 and 4.6 mg/l, respectively. The heart blood ethanol concentration was 0.27 g/dl. In addition, bupropion was distributed as follows: subclavian blood, 6.2 mg/l; bile, 1.4 mg/l; kidney, 2.4 mg/l; liver, 1.0 mg/kg; stomach contents, 16 mg and urine, 37 mg/l.     

Risk Terrain Modeling and Socio-Economic Stratification: Identifying Risky Places for Violent Crime Victimization in Bogotá, Colombia

This research focused on the effect of the built environment on Bogotá’s violent crime by using the Risk Terrain Modeling (RTM) technique. The current study used 17 ecological variables, including micro-level data on the spatial distribution of socio-economic strata, and the location of an array of businesses and other features of the landscape. As suggested by the results of this study, the spatial distribution of violent crime in Bogotá is highly correlated with the allocation of socio-economic strata throughout its geography. A statistically valid RTM analysis identified the micro-level risk factors associated with three types of violent crime incidents, namely homicide, assault, and theft incidents. These results suggest that future violent crime incidents are more likely to occur at a reduced number of high-risk micro-places. Moreover, while homicide and assault incidents were more likely to cluster within the poorest areas of the city, theft incidents presented a higher risk of victimization near the city center, where economic activity and suitable targets concentrate. This study offers a unique account regarding the effect of socio-economic segregation on violent crime victimization across Bogotá’s geography and within different socio-economic strata classifications.     

Risk Clusters,Hotspots, and Spatial Intelligence: Risk Terrain Modeling as an Algorithm for Police Resource Allocation Strategies

The study reported here follows the suggestion by Caplan et al. (Justice Q, 2010) that risk terrain modeling (RTM) be developed by doing more work to elaborate, operationalize, and test variables that would provide added value to its application in police operations. Building on the ideas presented by Caplan et al., we address three important issues related to RTM that sets it apart from current approaches to spatial crime analysis. First, we address the selection criteria used in determining which risk layers to include in risk terrain models. Second, we compare the “best model” risk terrain derived from our analysis to the traditional hotspot density mapping technique by considering both the statistical power and overall usefulness of each approach. Third, we test for “risk clusters” in risk terrain maps to determine how they can be used to target police resources in a way that improves upon the current practice of using density maps of past crime in determining future locations of crime occurrence. This paper concludes with an in depth exploration of how one might develop strategies for incorporating risk terrains into police decision-making. RTM can be developed to the point where it may be more readily adopted by police crime analysts and enable police to be more effectively proactive and identify areas with the greatest probability of becoming locations for crime in the future. The targeting of police interventions that emerges would be based on a sound understanding of geographic attributes and qualities of space that connect to crime outcomes and would not be the result of identifying individuals from specific groups or characteristics of people as likely candidates for crime, a tactic that has led police agencies to be accused of profiling. In addition, place-based interventions may offer a more efficient method of impacting crime than efforts focused on individuals.     

Detection of drugs using XAD-2 resin. III:A routine screening procedure for bile

The ability of bile to concentrate drugs and metabolites coupled with its general availability make it suitable for analysis and often the fluid of choice in postmorten cases requiring drug screening. Bile (5 to 10 ml) was diluted with water, sulfuric acid was added, and the mixture was autoclaved. The precipitated bile salts were easily removed by filtration and the filtrate (pH adjusted to 8.0 to 8.5) extracted with XAD-2 resin. Drugs were eluted with a mixture of ethyl acetate/1,2-dichloroethane and analyzed with thin-layer chromatography. Varying the dilution of bile improved the recovery of morphine, codeine, methadone, amobarbital, and phenobarbital. Excessive dilution, however, caused a washing phenomenon and reduced recovery of some drugs, as shown with morphine and codeine. The procedure described is useful for the rapid screening of bile specimens for drugs.