Detection of drugs using XAD-2 resin. I:Choice of resin, chromatographic conditions, and recovery studies

Amberlite XAD-2, a nonionic polystyrene divinylbenzene resin, was first used for the analysis of drugs in urine and a number of reports have described the development at optimal conditions for extraction, including type of resin columns, pH conditions, and eluting solvents. XAD-4 and XAD-7 resins were compared to the similarly structured XAD-2 resin and no significant advantage over the XAD-2 resin for drug screening was observed. A quantity of 5 to 6 g of resin was found to have sufficient capacity for the extraction of 200 ml of pentobarbital solution (1 mg/100ml). A column flow rate of approximately 15 ml/min (gravitational flow) was sufficient for analysis and slower rates were not more efficient. A mixture of ethyl acetate and 1,2-dichloroethane (3:2) was found to give best overall recovery (66 to 94%) of drugs, the resulting extracts being reasonably free of interfering substances. A pH value of 8.5 is recommended as optimum for comprehensive analysis of acidic and basic drugs. Recovery studies were conducted on spiked samples to determine drug losses occuring during various steps in the XAD-2 extraction procedure for four acidic (amobarbital, secobarbital, pentobarbital, and phenobarbital) and four basic (morphine, codeine, meperidine, and methadone) drugs. A relatively small amount (0 to 5%) of the drugs was not adsorbed by the resin and amounts varying from 6 to 40% failed to be desorbed by the eluting solvent. Additional losses occurred during the removal and analysis of TLC spots. Recovery of drugs from aqueous solutions analyzed with the XAD-2 resin were compared to recoveries reported in the literature with other XAD-2 resin methods for the extraction of drugs from urine. Recovery of phenobarbital, morphine, and codeine improved by 4 to 23% while recoveries of amobarbital, pentobarbital, secobarbital, methadone, and meperidine were 4 to 28% less efficient when compared to literature data.     

Assessing the Dayton Accord: The structural weaknesses of the general framework agreement for peace in Bosnia and Herzegovina

The General Framework Agreement for Peace in Bosnia and Herzegovina ‐ the Dayton Accord — brought a formal end to the war in Bosnia, but the prospects for an enduring peace remain uncertain. One of the obstacles to peace is the accord itself. This article outlines the main provisions of the agreement and then examines its structural weaknesses. These weaknesses, it is argued, though significant, may not be insuperable. There is broad scope for interpretation of the treaty's terms and for innovation within its framework. Its effectiveness in the long term will depend in part on whether the implementing powers succeed in exploiting this potential.     

Weather modification and war

Abstract

Although the cost already borne by the people of Indochina in terms of human deaths and injuries is staggering, still more suffering awaits them as a consequence of the lingering effects of the new use of an old weapon — environmental warfare — on a scale never before seen. Throughout the war, the United States systematically attacked the ecosystem through intense application of herbicides, large-scale bulldozing, attempted creation of firestorms, and the incredibly concentrated bombing, which cratered vast areas and repeatedly damaged the dikes in North Vietnam. This has created irreversible damage to the environment. In addition to serving the announced purpose of denying cover to the insurgents, it has become clear that the environmental warfare has had a more sinister purpose: to destroy the social structure that supports the National Liberation Front by removing millions of people from their ancestral homes and packing them into more easily controlled areas, such as urban slums and refugee camps.     

Positive versus normative economics: what’s?the?connection? Evidence from the Survey of?Americans and?Economists on the Economy and?the?General?Social?Survey

Previous research suggests that positive and normative beliefs about economics are largely unrelated. Using questions from two national surveys, this study finds that: (a)?the underlying determinants of positive and normative beliefs are strikingly similar; (b)?education is by far the strongest overall determinant of both positive and normative beliefs; and (c) the variables known to push positive beliefs in the same direction as formal economic training—education, male gender, income growth, and job security—also push normative beliefs in the same direction. These results strongly suggest that the positive-normative connection has been underestimated.     

In vitro accuracy and precision studies comparing direct and delayed analysis of the ethanol content of vapor

In vitro accuracy and precision studies were conducted using silica gel, magnesium perchlorate, and indium encapsulation breath collection tubes in conjunction with three infrared breath ethanol analyzers (BAC Verifier, Intoxilyzer 5000, and Intoximeter 3000), the Breathalyzer 900A, and the GC Mark IV. Statistical analyses revealed good accuracy and precision and correlation between direct and delayed vapor ethanol analyses for each combination of instruments and collection devices (range = 0.000 to 0.250 g/210 L, N = 42/instrument, r greater than 0.99). Delayed vapor ethanol analysis utilizing each instrument and collection device combination appears to predict satisfactorily original vapor ethanol concentrations.     

Thiamylal: review of the literature and report of a suicide

A 28-year-old white male medical student was found hanging by the neck from the bathroom closet of a hotel room. An intravenous infusion line leading from a bottle of thiamylal sodium (an ultrashort-acting barbiturate) was inserted into the antecubital vein of the left arm. Blood was analyzed for alcohol and other volatiles and for acidic, basic, and neutral drugs. Only thiamylal was detected. Thiamylal was quantified by high-performance liquid chromatography with ultraviolet detection, and its presence was confirmed by gas chromatography/mass spectrometry. The tissue distribution of thiamylal was 29 mg/L in blood, 1.4 mg/L in urine, 16 mg/L in bile, 135 mg/kg in liver, 25 mg/kg in kidney, and 0.4 mg in the stomach contents. The uptake and distribution of thiamylal is similar to thiopental. The distribution of the drug in this case was compared to that of other fatalities involving ultrashort-acting barbiturates.     

The financial implications of merging proactive CCTV monitoring and directed police patrol: a cost–benefit analysis

Objectives

This study presents a cost–benefit analysis of an intervention pairing proactive CCTV monitoring with directed police patrol in Newark, NJ. A recent randomized control trial found that the strategy generated significant crime reductions in treatment areas relative to control areas. The current study focuses on the financial implications of the experimental strategy through a cost–benefit analysis.

Methods

The study begins by measuring the costs and benefits associated with the experimental strategy, the findings of which can inform agencies with existing CCTV infrastructure. Follow-up analyses measure the costs and benefits of the intervention for agencies absent existing CCTV infrastructure, meaning a CCTV system would have to be funded in addition to the intervention outputs. Alongside overall benefits, this study presents the tangible cost savings afforded to the Criminal Justice system as well as to each of the separate criminal justice (CJ) system components: Policing, Courts, and Corrections.

Results

We found the experimental strategy to be highly cost effective for agencies with existing CCTV infrastructure. However, when the cost of the CCTV system is considered, the strategy is largely cost prohibitive. While the cumulative societal and criminal justice findings suggest some evidence of a modest cost savings, the strategy is highly cost prohibitive for each of the individual CJ system components when CCTV system costs are included.

Conclusions

Results suggest that the experimental strategy is a worthwhile investment for agencies with existing CCTV infrastructure. Agencies absent CCTV may want to consider whether funds would be better allocated towards alternate strategies.