Racially conditional donation: the example of umbilical cord blood

While direction of donated tissue to family members has long been accepted, direction to members of specific racial groups has been opposed, on the basis that it is discriminatory and contrary to the ethos the institution of organ donation seeks to promote. It has, however, recently been proposed that racially conditional donation may provide a useful--and ethically acceptable--way to address the social inequalities and injustices experienced by certain cultural groups. This article examines the ethical, legal and cultural arguments for and against racially conditional donation, concluding that the practice is more likely to undermine the values of equity and justice than to promote them and that it may also lead to other unfavourable personal and social outcomes.     

Findings in fatal cases of poisoning attributed to traditional remedies in South Africa.

An analysis of the Johannesburg forensic database over the years 1991-1995 revealed 206 cases in which a traditional remedy was either stated to be the cause of death or was found to be present in a case of poisoning with an unknown substance. The range of toxins detected was wide, with herbal materials being found in 43% of cases, and pharmaceutical or agri-chemicals in 20% and 33% respectively. Since there are as yet no standard methods for the detection of many herbal remedies or their metabolites, careful analysis, using methods such as HPLC/MS, are mandatory for the correct identification of the true cause in cases of poisoning ascribed to traditional remedies.     

Socio‐legal Studies in France: Beyond the Law Faculty

This article is the third in an occasional series dealing with the development, current status, and future of socio‐legal studies in selected countries. It follows articles by Kim Economides (Aotearoa/New Zealand) and Harry Arthurs and Annie Bunting (Canada). In this article we argue that in France one can identify work that corresponds to the key strands of socio‐legal research in Anglo‐American societies but that ‘socio‐legal’ as a category of research and scholarship does not have the presence it has in the United Kingdom. French law faculties continue to be strongly shaped by a traditional disciplinary orthodoxy rooted in a highly and distinctively structured form of doctrinal analysis. In the first part, we explain the relatively limited presence of socio‐legal studies in French law faculties in terms of the historical and institutional mechanisms by which disciplinary closure has been created and maintained around traditional orthodoxies. But in the second part we will trace the presence – predominantly outside law faculties – of significant fragments of socio‐legal practice in the scholarship of law and allied disciplines.     

Self-control, Victimization, and their Influence on Risky Lifestyles: A Longitudinal Analysis Using Panel Data

This research expands past investigations into the influence of low self-control as a risk factor for criminal victimization. Specifically, we consider two questions: (1) whether low self-control at one point in time can predict future victimization, and (2) whether victims alter lifestyle choices (like their own delinquency and contact with delinquent peers) in response to their earlier victimization. We answered these questions using three waves of adolescent panel data from the evaluation of the Gang Resistance Education and Training program. Our results support the predictions of self-control theory, showing that low self-control measured at an earlier time is associated with later victimization, even after controlling for past victimization, delinquency, social bonds, and delinquent peer contact. Likewise, self-control appears to influence the relationship between earlier victimization and later lifestyles.

Evaluation of a multicapillary electrophoresis instrument for mitochondrial DNA typing

Laser-induced detection of fluorescent labeled PCR products and multi-wavelength detection (i.e., multicolor analysis) enables rapid generation of mtDNA sequencing profiles. Traditionally, polyacrylamide slab gels have been used as the electrophoretic medium for mtDNA sequencing in forensic analyses. Replacement of slab gel electrophoresis with capillary electrophoresis (CE) can facilitate automation of the analytical process. Automation and high throughput can be further enhanced by using multicapillary electrophoretic systems. The use of the ABI Prism 3100 Genetic Analyzer (ABI 3100, Applied Biosystems, Foster City, CA) as well as the ABI Prism 310 Genetic Analyzer (ABI 310, Applied Biosystems, Foster City, CA) were evaluated for mtDNA sequencing capabilities and compared with sequencing results obtained on the platform currently in use in the FBI Laboratory (the ABI Prism 377 DNA Sequencer, ABI 377, Applied Biosystems, Foster City, CA). Various studies were performed to assess the utility of the ABI 3100, as well as the ABI 310 for mtDNA sequencing. The tests included: comparisons of results obtained among the ABI 3100, the ABI 310 and the ABI 377 instruments; comparisons of results obtained within and between capillary arrays; evaluation of capillary length; evaluation of sample injection time; evaluation of the resolution of mixtures/heteroplasmic samples; and evaluation of the sensitivity of detection of a minor component with reduced template on the ABI 3100. In addition, other studies were performed to improve sample preparation; these included: comparison of template suppression reagent (TSR, Applied Biosystems, Foster City, CA) versus formamide; the use of Performa DTR Gel Filtration Cartridges (Edge BioSystems Inc., Gaithersburg, MD) versus Centri-Sep Spin Columns (Princeton Separations, Adelphia, NJ) for product purification after cycle sequencing; and sample stability after denaturation. The data support that valid and reliable results can be obtained using either capillary electrophoresis instrument, and the quality of sequencing results are comparable to or better than those obtained from the ABI 377 instrument.     

Supercritical fluid chromatography in forensic science: a critical appraisal

The application of supercritical fluid chromatography (SFC) in forensic science is reviewed. The applications centre on the analysis of explosives and of drugs of abuse. The systems employed are discussed in the context of comparison with gas chromatography and high-performance liquid chromatography methods which are traditionally used for such analyses. The advantages and disadvantages of SFC over these methods are discussed. Recommendations are made for the developments which are required in SFC technology if it is to find greater application in forensic science.     

Long and Short Run Determinants of Small and Medium Size Enterprise Share: The Case of Venezuelan Manufacturing

Economic Change and Restructuring - Two recent studies of SME share determination have employed a partial adjustment model which specifies disequilibrium as the sole means of explanation....     

The Spatial Patterning of County Homicide Rates: An Application of Exploratory Spatial Data Analysis

The possibility that homicides can spread from one geographic area toanother has been entertained for some time by social scientists, yetsystematic efforts to demonstrate the existence, or estimate the strength,of such a diffusion process are just beginning. This paper uses exploratoryspatial data analysis (ESDA) to examine the distribution of homicides in 78counties in, or around, the St. Louis metropolitan area for two timeperiods: a period of relatively stable homicide (1984–1988) and aperiod of generally increasing homicide (1988–1993). The findingsreveal that homicides are distributed nonrandomly, suggestive of positivespatial autocorrelation. Moreover, changes over time in the distribution ofhomicides suggest the possible diffusion of lethal violence out of onecounty containing a medium-sized city (Macon County) into two nearbycounties (Morgan and Sangamon Counties) located to the west. Althoughtraditional correlates of homicide do not account for its nonrandom spatialdistribution across counties, we find some evidence that more affluentareas, or those more rural or agricultural areas, serve as barriers againstthe diffusion of homicides. The patterns of spatial distribution revealedthrough ESDA provide an empirical foundation for the specification ofmultivariate models which can provide formal tests for diffusion processes.     

Affirmative action,duality of error,and the consequences of mispredicting the academic performance of african american college applicants

The implications of different potential affirmative action policies depend on three factors: selection rate from the applicant pool, base rate of qualified applicants, and accuracy of performance predictions. A series of analyses was conducted under various assumptions concerning affirmative action plans, causes of racial differences in average college admissions test scores, and racial differences in accuracy of performance predictions. Evidence suggesting a lower level of predictive accuracy for African Americans implies that, under a program of affirmative action, both proportionately more false positives (matriculated students who do not succeed) and proportionately more false negatives (rejected applicants who could have succeeded) will be found among African American applicants. Unless equivalent levels of predictive accuracy are achieved for both groups, no admission policy can be fair simultaneously to majority group applicants and African American applicants. © 2002 by the Association for Public Policy Analysis and Management.