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421.
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The purpose of this study was to evaluate the efficiency of the Cozart® RapiScan (CRS) drug test system for detecting opiates and cocaine in oral fluid. Oral fluid samples were collected using the Cozart® RapiScan collection system from 358 donors who were receiving treatment for their addiction and were monitored for drug misuse. A further 103 oral fluid samples were collected from volunteer donors who were not drug users. The samples were analyzed in the laboratory using the two-panel Cozart® RapiScan cartridge for opiates and cocaine and confirmed using gas chromatography–mass spectrometry (GC–MS). The samples were stored frozen at −20 °C until analysis by GC–MS. The overall accuracy of the CRS for both opiates and cocaine was 100%. Samples spiked at 50% above and below the cut-off consistently gave negative and positive results respectively. A total of 88 samples were positive for various opiates and 111 samples were positive for cocaine and/or its metabolites. The CRS for opiates and cocaine in oral fluid, using a cut-off of 30 ng/mL morphine or benzoylecgonine equivalents in neat oral fluid, had overall efficiencies of 98% and 99%, respectively, versus GC–MS. A series of potential adulterants of oral fluid were evaluated and shown not to alter the outcome of the test result.  相似文献   
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The advent of ministerial advisers of the partisan variety – a third element interposing itself into Westminster's bilateral monopoly – has been acknowledged as a significant development in a number of jurisdictions. While there are commonalities across contexts, the New Zealand experience provides an opportunity to explore the extent to which the advent of ministerial advisers is consistent with rational choice accounts of relations between political and administrative actors in executive government. Public administration reform in New Zealand since the mid 1980s – and in particular machinery of government design – was quite explicitly informed by rational choice accounts, and normative Public Choice in particular. This article reflects on the role of ministerial advisers in the policy‐making process and, on the basis of assessments by a variety of political and policy actors, examines the extent to which the institutional and relational aspects of executive government are indeed consistent with rational choice accounts of the ‘politics of policy‐making’. The reader is offered a new perspective through which to view the advent, and the contribution of ministerial advisers to policy‐making in executive government.  相似文献   
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There has been substantial growth in the number of non-elected public bodies – or quangos – operating at the local level. This development presents a marked change from the model of elected local authorities as the main focus for the governance and delivery of local public services. Four interpretations of this change are examined: agency-type, ideological control, managerial restructuring and regulationist explanations. Agency-type explanations recognize a plurality of factors, but lack theoretical or predictive rigour. Ideological and managerial explanations have a stronger theoretical basis but fail to recognize the wider structural context. Regulationist explanations offer, but also suffer from the problems of, structuralist analysis. An integrating framework is developed. Three phases in the development of local quangos are presented as a process by which government has resolved tensions in the British state. A consequence, however, has been to raise questions about the state's longer term legitimacy.  相似文献   
427.
Expansion of the manufacturing extension system, and consequent diversification of center models and services, suggest the evaluation system may need to expand its focus to take into account diverse program features and outcomes and the need to use evaluation data in different state political economy contexts. In the Wisconsin environment detailed here, demonstrating hard “taxpayer-payback” and shaping the politician's view of manufacturing extension as an “investment,” rather than as an “expenditure” item, may be important requirements for future in-state manufacturing extension funding. This article attempts to demonstrate empirically the taxpayer-payback outcomes to manufacturing extension activities, using representative corporation financial balance sheet data, along with field-credible scenarios about simulated extension service impacts on the balance sheets, and actual program service costs and fee levels. The implications of the analysis are explored both for program evaluation and the broader economic and political justification of manufacturing extension at state and national levels. the views expressed here are those of the author and do not reflect official policy of the National Institute for Standards and Technology. The author would like to thank Philip Shapira, Jan Youtie, Betsy Bury, Dan Luria, and participants at the 1996 NIST/Georgia Tech workshop on manufacturing modernization, for their comments and assistance.  相似文献   
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This article explores the role of consumer advocacy. Those involved in public policy formation and administration – regulators, governments and other public policy makers – share an interest in effective consumer advocacy. Those who make our laws, as well as those who are custodians of its adjudication, compliance, monitoring and enforcement, share a common position with many consumer advocates – they all work to advance the long‐term interests of consumers.  相似文献   
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