Thinking alike: two pathways to leadership-candidate opinion congruence

This paper seeks to explain why party candidates and their party leadership have congruent policy positions or not. Despite its importance as a way through which parties are able to behave as a unitary actor, this congruence has never been studied as a dependent variable. We seek to fill this void in the literature. Our results suggest that leadership-candidate congruence comes about through two mechanisms: selection and learning. With selection, the party leadership aims to get those candidates elected whose policy preferences are congruent with the party line. Learning occurs through the process of socialization in which candidates assume the views of the party they work and candidate for as their own under. This happens under the pressure of cognitive dissonance. If a candidate learns about the position of the leadership and notices that they are incongruent, they may feel discomfort and change their opinion to be congruent with the party.     

Fatal hemorrhage from a periumbilical wound: Stabbing or hemorrhage from a caput medusae?

Varices are the main clinical manifestation of portal hypertension, and their bleeding is the predominant cause of mortality from this condition. Periumbilical varices are known as “caput medusae.” Reports of their bleeding are rare, with only three fatal cases described in the literature. The antemortem diagnosis is relatively simple, while the postmortem diagnosis is more complex. This paper is the first report of fatal hemorrhage from a caput medusae for which the diagnosis was made postmortem, thanks to a complete diagnostic process including scene and circumstances, medical history, and autopsy with detailed histology. The circumstantial analysis showed the presence of a large amount of blood at the scene, blood which originated from a small abdominal wound; an analysis of the subject's clinical data reported that he was affected by portal hypertension. The autopsy revealed some dilated and convoluted veins in the subcutaneous tissue of the umbilical region; a fistula between these veins and the abdominal wound was detected. The histological study confirmed the presence of periumbilical varices, one of them ruptured and connected with the overlying skin. The cause of death was attributed to a massive hemorrhage generated by a periumbilical varix in a patient affected by portal hypertension.     

3D forensic facial approximation: Implementation protocol in a forensic activity

The primary objective of this paper is to report on the successful implementation of forensic facial approximation in a real case in the forensic context. A three‐dimensional (3D) facial approximation protocol of the skull was performed with free software, applying techniques in a virtual environment that have already been consolidated in the literature. The skull was scanned with the photogrammetry technique, the digital replica was imported in the Blender software (Blender Foundation, Amsterdam) and individualized model sketches of the face were traced with the MakeHuman software (MakeHuman Org) according to the anthropological profile of the victim. The face created was imported in Blender, where it was adapted, modeled, and sculpted on the 3D skull and its soft tissue markers, using an American open‐source application of the technique in the digital environment. The face created in a virtual environment was recognized and legal identification procedures were started, resulting in the more agile delivery of the disappeared body to its next of kin. It is therefore concluded that facial approximation may not be a primary method of human identification, but it can be satisfactorily applied in the forensic field as an individual recognition resource. It has great value in narrowing the search, reducing the number of alleged victims, and leading to identification tests, therefore significantly reducing the number of genetic DNA (deoxyribonucleic acid) tests—which are considered costly for the State or Federation—and consequently reducing the waiting time before delivery of the body to its family.     

Primary intimal sarcoma of the pulmonary artery misdiagnosed as pulmonary thromboembolism: A case confirmed at medicolegal autopsy

Misdiagnosed PAS confirmed at medicolegal autopsy Pulmonary artery sarcoma (PAS) is a rare disease and usually indistinguishable from acute or chronic thromboembolic disease of the pulmonary arteries. We present a case of pulmonary artery sarcoma in a 54‐year‐old male, who was clinically misdiagnosed as pulmonary thromboembolism. The patient died of disease; however, the actual diagnosis of PAS was made after a medicolegal autopsy. PAS can be a diagnostic challenge for both clinicians and pathologists. In an autopsy case with a clinical suspicion of pulmonary thromboembolism, if there is an abnormal gross appearance in the pulmonary artery, the forensic pathologist should have a high index of suspicion of PAS, which should be ruled out by a histopathologic examination.     

Intentional overdose of glargine insulin: Determination of the parent compound in postmortem blood by LC-HRMS

Insulin glargine is a long-acting insulin analog that is converted after enzymatic cleavage of the arginine pair of the β-chain into its main metabolite M1 (21^A-Gly-insulin), which is responsible for the hypoglycemic activity. In all the overdose cases described in the literature, only M1 concentrations have been reported, whereas insulin glargine was always absent or below the limit of quantitation. In this study, we present a case of suicide of a young nurse by injection of insulin glargine in which the parent molecule was found at a toxic concentration in blood. The determination and the discrimination of insulin glargine from human insulin and other synthetic analogs in the blood specimen were performed by liquid chromatography coupled to high-resolution mass spectrometry (Waters XEVO G2-XS QToF) and extraction after precipitation in the presence of bovine insulin (internal standard), with a mixture of acetonitrile/methanol +1% formic acid followed by purification on solid phase extraction cartridges C18. Glargine insulin tested highly positive in the blood with a concentration of 1.06 mg/L. Due to the difficulty in obtaining a M1 pure standard, the metabolite could not be dosed. This unique presence of the parent molecule, reported for the first time, can be explained by inter-individual variability in the rate of conversion to metabolite. Intravenous injection versus subcutaneous injection can also explain the presence of insulin glargine. Finally, the dose injected may have been so high that saturation of the proteolytic enzymes responsible for conversion to M1 should have occurred.     

Radiodense bullet wipe around osseous entrance gunshot wounds

“Bullet wipe” is the material deposited by a bullet on any surface with which it comes into contact after it is fired and may contain debris from the gun barrel, including particles of primer and metal fragments from previously fired bullets. X‐ray analysis is a non‐destructive method by which traces of metallic elements can be visually detected. The analysis of osseous defects for radiodense bullet wipe (RBW) assists in determining the presence or absence of perforating gunshot wounds, especially in fragmented, skeletonized remains. The aim of our current study was to determine the frequency of RBW around entrance firearms injuries that perforated bone. We prospectively analyzed entrance gunshot wounds for RBW over a three‐year period using digital X‐ray analysis (n = 59). We retrospectively reviewed the corresponding autopsy reports to determine the frequency of RBW by biologic sex, reported ancestry, age‐at‐death, location of wound, manner of death, range of fire, bullet caliber, and presence of bullet jacket. Data were analyzed by Fisher's exact test or Chi‐square test with significance levels accepted at p < 0.05. RBW was present in 66% (n = 39) of examined cases. Decedent characteristics did not significantly alter RBW distribution, including biologic sex (p = 0.75), reported ancestry (p = 0.49), and age‐at‐death (p = 0.43). Additionally, the location of the osseous entrance gunshot wound, manner of death, range of fire, and cartridge caliber did not affect RBW detection. All cases involving non‐jacketed rounds (n = 5) showed RBW (p = 0.30). To our knowledge, this study is the first to report the frequency of RBW detection from osseous entrance gunshot wounds.     

Translating Technical Diplomacy: The Participation of Civil Society Organisations in International Standardisation

ABSTRACT

This article examines the participation of civil society organisations (CSO) in the various arenas of global governance with focus on the International Organization for Standardization (ISO). While diverse studies recognise the difficulty of CSOs’ participation despite the growing importance of standards in the organisation of markets, little attention has been paid to how such involvement is likely to be reinforced in what we call “technical diplomacy”, the negotiating processes involving states and non-state actors geared toward setting specifications claiming to be based on scientific knowledge. Drawing upon scholarship in new forms of regulation in organisational studies, international relations, and science and technology studies, the paper argues that CSOs’ participation depends on multiple translation practices between lay- and expert-knowledge. Findings are based on an action-research project, INTERNORM, pooling academic and CSO participation in ISO technical committees. It suggests some promising directions for addressing the democratic deficit of technical diplomacy.     

The Sangh Parivar and the Hindu Diaspora in the West:What Kind of "Long-Distance Nationalism"?

"Long-distance nationalism," an expression coined by Benedict Anderson, is often used to refer to transnational political activities, but the dynamics of this expatriate nationalism tend to be neglected. Mere nostalgia or even spontaneous mobilizations are invoked to explain this phenomenon, but fail to explain the mechanisms that lie behind it. Using the example of Hindu nationalist movements, this paper seeks to highlight the implications of political entrepreneurs in the country of origin and the instrumental dimension of long-distance nationalism. The Sangh Parivar, a network of nationalist Hindu organizations, was replicated among the Hindu diaspora and its structure was literally exported by a centralized body located in India itself. The spread of the Sangh Parivar and of its Hindutva ideology abroad was greatly facilitated by local policies like multiculturalism and by the rise of racism in the countries of emigration. A comparison of Hindu nationalist outlets in the United Kingdom, the United States, and Canada brings to light two main factors instilling long-distance nationalism: a favorable local context for ethnic mobilization among migrants and a centralized organization in the country of origin. The engineering of long-distance Hindu nationalism from India questions the changing nature of nationalism in a globalized world.     

India's look east policy: an Asianist strategy in perspective

Indian nationalist leaders developed a strong interest in Asia right from the early nineteenth century. Jawarharlal Nehru articulated an Asianist ideology based on the cultural affinities between India and China and the geopolitical interest in Greater India. This approach, which culminated in the Bandung summit, was put into parenthesis after the 1962 war. The Cold War, during which India and South East Asia were in different camps, prompted differing paths towards in emulating the economic progress of Japan, Taiwan and South Korea, and different approaches towards the development of the ASEAN. India's Asianist policy met an uneven fate but, by and large, there has been a significant rapprochement between India and East Asia. This move materialized in the investments of several Asian countries – including South Korea – in India and the entry of India in the ARF. Yet the symbiosis between India and Southeast Asia remains hindered by the rather nationalistic view of the latter region that the Hindutva movement is still propagating: like in the colonial period, Asianism remains part of an instrumentalist strategy.     

Detection of amitriptyline, nortriptyline and bromazepam in liver, CSF and hair in the homicidal poisoning of a one-month-old girl autopsied 8 months after death

We reported on the death by poisoning of a one-month-old baby that had followed the death of one of her sister (due to cyamemazine overdose). Exhumation of the corpse was done 8 months after burial and revealed the presence of amitriptyline. Parent drug and its metabolite were analysed by HPLC-MS/MS in positive ionisation mode on a C(18) analytical column using a gradient of acetonitrile and 2mM formate buffer at pH=3. Quantification is based on the main ion m/z=233, the common product ion of nortriptyline (MH(+), m/z 264), amitriptyline (MH(+), m/z 278) and nortriptyline D3 used as internal standard (MH(+), m/z 267). Amitriptyline and nortriptyline in the liver were measured at a concentration of 29.8 and 3.6 μg/g, respectively. Hair analyses revealed the presence of amitriptyline and nortriptyline at concentrations of 1811 and 43 pg/mg, respectively, while complementary analyses showed the presence of bromazepam in the hair at a concentration of 740 pg/mg, thus documenting previous administrations. The mother confessed later having used the drinkable form of the pharmaceutical LAROXYL(?) by pouring the content of a 20 ml bottle (at 40 mg/ml) into the feeding-bottle of her child. The milk was sweet but still bitter and following the testimony of a close relative, the whole family helped to feed the crying baby.