Partial Agonist Therapy in Schizophrenia: Relevance to Diminished Criminal Responsibility

Abstract: Pathological gambling (PG), classified in the DSM‐IV among impulse control disorders, is defined as inappropriate, persistent gaming for money with serious personal, family, and social consequences. Offenses are frequently committed to obtain money for gambling. Pathological gambling, a planned and structured behavioral disorder, has often been described as a complication of dopamine agonist treatment in patients with Parkinson’s disease. It has never been described in patients with schizophrenia receiving dopamine agonists. We present two patients with schizophrenia, previously treated with antipsychotic drugs without any suggestion of PG, who a short time after starting aripiprazole, a dopamine partial agonist, developed PG and criminal behavior, which totally resolved when aripiprazole was discontinued. Based on recent advances in research on PG and adverse drug reactions to dopamine agonists in Parkinson’s disease, we postulate a link between aripiprazole and PG in both our patients with schizophrenia and raise the question of criminal responsibility.     

Fatal Overdose of Gamma‐hydroxybutyrate Acid After Ingestion of 1,4‐Butanediol

We report a case of fatal intoxication from 1,4‐butanediol (1,4‐BD), which was ingested by a young and “naïve” gamma‐hydroxybutyrate (GHB) consumer during a party with the co‐ingestion of alcohol, cannabis, and methylene‐dioxy‐methamphetamine. The following drug concentrations were found using gas chromatography coupled with mass spectrometry on autopsy samples and on a cup and a glass found at the scene: 20,350 mg/L (bottle) for 1,4‐BD; 1020 mg/L (femoral blood), 3380 mg/L (cardiac blood), 47,280 mg/L (gastric content), and 570 mg/L (vitreous humor) for GHB. The concentration of GHB is difficult to interpret in forensic cases due to the possibility of an endogenous production of GHB. The variable tolerance of the user may also modify the peri‐ and postmortem GHB concentrations. This case underscores the need to have many different sources of toxicology samples analyzed to avoid the hypothesis of endogenous production of GHB.     

Discrete Traits of the Sternum and Ribs: A Useful Contribution to Identification in Forensic Anthropology and Medicine

During forensic anthropological investigation, biological profile is determined by age, sex, ancestry, and stature. However, several individuals may share the same profile. Observation of discrete traits can yield useful information and contribute to identification. This research establishes the frequency of discrete traits of the sternum and ribs in a modern population in southern France, using 500 computer tomography (CT) scans of individuals aged 15–60 years. Only discrete traits with a frequency lower than 10% according to the literature were considered, a total of eight traits. All scans examined were three‐dimensional (3D) volume renderings from DICOM images. In our population, the frequency of all the discrete traits was lower than 5%. None were associated with sex or age, with the exception of a single trait, the end of the xiphoid process. Our findings can usefully be applied for identification purposes in forensic anthropology and medicine.     

Establishing the most appropriate databases for addressing source level propositions.

Previous papers in Science & Justice have described the work of the Case Assessment and Interpretation (CAI) project that has been running for several years within the Forensic Science Service (FSS). The principles of the CAI model, which have developed through casework, are the foundation of a balanced, robust and logical approach to interpretation. The question arises frequently as to what is the most appropriate database that should be available to assist in assigning a value to a given probability. In this paper we present a set of guidelines in the form of flowcharts and explore them within the context of a range of case examples.     

A study in relation to the random distribution of four fibre types on clothing (incorporating a review of previous target fibre studies).

A new target fibre study was undertaken building upon eight previous published studies, which are reviewed here. Fifty-eight items of outer clothing, obtained from households across England, were taped and searched for three types of commonly occurring fibres and one less common fibre type. The tapes were examined using a combination of automatic and manual searching. Any fibres similar to the target fibres were removed and examined using microspectrophotometry, comparison microscopy, thin layer chromatography (TLC) and fourier transform infrared spectroscopy (FTIR) where applicable. One polyester fibre, four acrylic fibres and eleven wool fibres were found that matched the three commonly occurring target fibre samples. None of the less common polyester fibres were found. One item had six matching wool fibres and another had the polyester fibre and an acrylic fibre recovered from it. The remaining eight fibres were each recovered from individual items. The results suggest that finding a large number of fibres that match a control is unlikely to happen by chance, which supports the findings of the previous target fibre studies.     

Results of the Corporate Affairs Survey 2004

The Corporate Affairs Survey 2004 confirms that companies with representation in Brussels continue to increase their communications expenditure. This confirms a trend already identified by the European Centre for Public Affairs in various publications¹ during the 1990s. Realising the importance of public opinion in policy making, the majority of companies are increasing the size of their Brussels staff, with a deliberate emphasis on communication and further resources in public affairs. As most companies recognise the special skill sets of consultants, many plan to continue relying on the latter, particularly in the area of public relations. Copyright © 2004 Henry Stewart Publications     

Hormones, Risk Management, Precaution and Protectionism: An Analysis of the Dispute on Hormone-Treated Beef between the European Union and the United States

The first commercial dispute settled by the WTO under the Sanitary and Phytosanitary Agreement concerned the disagreement between the European Communities and the United States over the European import ban on meat and meat products derived from cattle to which hormones have been administered for growth promotion purposes. The purpose of this paper is twofold: First, we analyse the WTO's approach to the notion of risk in the use of hormones and the role this played in reaching its decision to declare the EC ban on hormone-treated beef imports inconsistent with its obligations under the Sanitary and Phytosanitary Agreement. Second, we discuss the way in which the precautionary principle has been dealt with in the settlement of this conflict. We then show how this dispute has paved the way to a debate on the concept of protectionism to be applied in this kind of dispute. The European Commission in a recent communication on the precautionary principle has launched this debate.     

Initial Results on the Composition of Fingerprints and its Evolution as a Functionof Time by GC/MS Analysis

Abstract: Determining the time since deposition of fingermarks may prove necessary to assess their relevance to criminal investigations. The crucial factor is the initial composition of fingermarks, because it represents the starting point of any aging model. This study mainly aimed to characterize the initial composition of fingerprints, which show a high variability between donors (inter‐variability), but also to investigate the variations among fingerprints from the same donor (intra‐variability). Solutions to reduce this initial variability using squalene and cholesterol as target compounds are proposed and should be further investigated. The influence of substrates was also evaluated, and the initial composition was observed to be larger on porous surface than nonporous surfaces. Preliminary aging of fingerprints over 30 days was finally studied on a porous and a nonporous substrate to evaluate the potential for dating of fingermarks. Squalene was observed to decrease in a faster rate on a nonporous substrate.