Simultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS. Application to the determination of MDMA after low ecstasy intake

A rapid and sensitive method using LC-MS/MS triple stage quadrupole for the determination of traces of amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"), 3,4-methylenedioxyethamphetamine (MDEA), and N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB) in hair, blood and urine has been developed and validated. Chromatography was carried out on an Uptisphere ODB C(18) 5 microm, 2.1 mm x 150 mm column (Interchim, France) with a gradient of acetonitrile and formate 2 mM pH 3.0 buffer. Urine and blood were extracted with Toxitube A (Varian, France). Segmented scalp hair was treated by incubation 15 min at 80 degrees C in NaOH 1M before liquid-liquid extraction with hexane/ethyl acetate (2/1, v/v). The limits of quantification (LOQ) in blood and urine were at 0.1 ng/mL for all analytes. In hair, LOQ was <5 pg/mg for MA, MDMA, MDEA and MBDB, at 14.7 pg/mg for AP and 15.7 pg/mg for MDA. Calibration curves were linear in the range 0.1-50 ng/mL in blood and urine; in the range 5-500 pg/mg for MA, MDMA, MDEA and MBDB, and 20-500 pg/mg for AP and MDA. Inter-day precisions were <13% for all analytes in all matrices. Accuracy was <20% in blood and urine at 1 and 50 ng/mL and <10% in hair at 20 and 250 pg/mg. This method was applied to the determination of MDMA in a forensic case of single administration of ecstasy to a 16-year-old female without her knowledge during a party. She suffered from hyperactivity, sweating and agitation. A first sample of urine was collected a few hours after (T+12h) and tested positive to amphetamines by immunoassay by a clinical laboratory. Blood and urine were sampled for forensic purposes at day 8 (D+8) and scalp hair at day 60 (D+60). No MDMA was detected in blood, but urine and hair were tested positive, respectively at 0.42 ng/mL and at 22 pg/mg in hair only in the segment corresponding to the period of the offence, while no MDA was detectable. This method allows the detection of MDMA up to 8 days in urine after single intake.     

Evaluation of preliminary isotopic analysis (13C and 15N) of explosives A likelihood ratio approach to assess the links between semtex samples

Currently, the use of isotopic ratio as corroborative evidence in criminal trials is explored. Beyond the analytical challenges that have been reported elsewhere, the crucial issue of the interpretation of analytical results in a fair and balanced way remains poorly documented. The aim of this paper is to propose a likelihood ratio approach for the evaluation of stable isotope data acquired from semtex samples. It will also lead to recommendations in relation to the acquisition of normalised international data.     

Development of a harmonised method for the profiling of amphetamines: IV. Optimisation of sample preparation

The suitability of liquid-liquid extraction (LLE) and solid-phase extraction (SPE) for the preparation of impurity extracts intended for gas chromatographic profiling analyses of amphetamine were evaluated. Both techniques were optimised with respect to the extraction of selected target compounds by use of full factorial designs in which the variables affecting the performance were evaluated. Test samples consisted of amphetamine synthesised by the Leuckart reaction, by reductive amination of benzyl methyl ketone and by the nitrostyrene route. The performance of LLE and SPE were comparable in terms of repeatability and recovery of the target compounds. LLE was considered the better choice for the present harmonised amphetamine profiling method due to the lack of information on the long-term stability of SPE columns.     

Returning to the child welfare system: Understanding the wellbeing,health, education,and placement of children who return

Using longitudinal archival Child Welfare System (CWS) data, this study describes child health and wellbeing at their initial entrance into the CWS and subsequent returns. Associations between child wellbeing, health, placement stability, and frequency of returning to the system were also investigated. Results indicated most children were healthy and developmentally on target. In addition, emotional distress, behavioral concerns, and number of placements in the CWS were significantly correlated with placement stability. Future work should utilize the use of developmental assessments to systematically and reliably document the concerns for children in the system, and investigate factors contributing to stable placements.     

Personality features of an adolescent female offending population

The incidence of adolescent offending has been shown to be different for young males and females. However, there is a lack of literature concerning adolescent female offenders, and despite research suggesting that personality factors may be linked with antisocial and criminal behaviour in adolescents and young adults; there have been a lack of studies investigating intra-sex personality differences in young female populations. The Millon Adolescent Clinical Inventory, a 160-item self-report personality measure, was administered to 26 non-offending and 28 offending adolescent females. It was found that the offending group was significantly less submissive, less conforming, more forceful, more oppositional and more likely to exhibit borderline personality traits than the control group. The offending group also had higher reported incidences of childhood abuse and family conflict, and were more prone to substance abuse, impulsive actions and suicide ideation. These initial findings suggest that personality differences may well exist between offending and non-offending adolescent females.     

Politicized CSR: How corporate political activity (mis-)uses political CSR

In this article, we posit that corporate political activities (CPA) such as lobbying make use of corporate social responsibility (CSR) to advance instrumental goals. We juxtapose the theoretical foundations of the normative concept of political CSR and the strategic notion of nonmarket strategy to show that they are in opposition conceptually regarding the role of corporations in public policy. Using a systematic theoretical comparison along seven dimensions, we discuss the juxtapositions and identify the common ground of the two theories. Building on examples from the alcohol industry, we describe how CPA uses instrumental CSR to advance goals in public policy—we call this politicized CSR. Hence, we illustrate the shift from political to politicized CSR, a misuse of CSR for purposes of CPA, and discuss consequences for the theory and practice of public affairs and CSR.     

Gauging the Rigor of Qualitative Case Studies in Comparative Lobbying Research. A Framework and Guideline for Research and Analysis

Engaging in comparative lobbying research is a challenging task, because public affairs is complex and highly context-dependent. Thus, qualitative case studies have been researchers' primary choice. However, the case method has been subject to much debate surrounding its rigor, in terms of reliability, internal validity, and generalizability, and particularly its potential for theory building. To propose a framework for researchers conducting lobbying case studies as well as for reviewers receiving such work, we apply a positivistic approach on case study rigor from management studies and expand the framework to tackle the specific challenges of comparative qualitative lobbying research. Thus, we expand the research framework by a set of variables specific to public affairs: We add enrichment for internal validity, contextuality, and comparability for external validity, interdisciplinarity for construct validity, and hypertext-searchable databases for reliability. Thereby, we aim to transfer the lessons learned from management studies in terms of rigorous qualitative case studies to public affairs to help build novel and explanatory theory in the field and to provide guidance to researchers how to design a rigorous case study.     

Still sucked into the body image thing: the impact of anti-aging and health discourses on women's gendered identities

Health norms have changed over the past three decades, imposing more responsibility for health onto the individual. There are gendered implications of these changes which, when combined with increasing anti-aging pressures, have the potential to intensify the disciplinary relationship women have with their bodies. This paper, based upon interviews with 14 women, examines the impact of dominant health and anti-aging discourses on women's body practices, including exercise, makeup, clothing and diet, and ongoing construction of gendered subjectivity. Findings suggest that the women in this study are motivated to do particular body practices because of their concern with having a healthy and youthful ‘looking’ body. The women's stories reveal that anti-aging and health discourses function to reinforce normative bodily demands of femininity and consequently to intensify disciplinary control of their bodies. While the pressure to fight the appearance of aging is not new, the increasing association of aging with ill health, even illness, in conjunction with the promotion of health has implications for women's relationship with their bodies and sense of self.