Development of a harmonised method for the profiling of amphetamines VI: Evaluation of methods for comparison of amphetamine

Amphetamine samples were analysed by gas chromatography-mass spectrometry (GC-MS), and the peak areas of 33 target compounds were transformed by applying various pretreatment techniques. The objective was to optimise the ability of a number of distance metrics to establish links between samples of amphetamine originating from the same batch (henceforth referred to as linked distances). Furthermore, partial least squares discriminant analysis (PLS-DA) was used to evaluate the effects of various pretreatment methods on separation of amphetamine batches synthesised by the Leuckart reaction, reductive amination of benzyl methyl ketone, and the nitrostyrene route. The most efficient way to pretreat GC-MS data varied for the different distance metrics, although best results were obtained when data were normalised to the sum of peak areas, and either the fourth root or a logarithm was applied to the normalised data. When pretreating normalised data by fourth root transformation, Pearson correlation was the distance metric that was most successful at finding linked samples. Normalisation and the use of fourth root also represented the best method of pretreating data when employing PLS-DA to separate samples synthesised by different routes. To achieve a faster and more user-friendly procedure for evaluating chromatograms, experiments were performed in which the number of target compounds used to compare samples was reduced. The effect of each compound that was removed was studied by applying PLS-DA and by using Pearson correlation to calculate linked distances as well as unlinked distances (between samples from different batches of amphetamine). Considering both links between samples from the same batch and separation of samples synthesised by different routes, the best results were obtained with the data set comprising 26 compounds. Finally, it was found that the profiling method developed in this work was superior to an existing technique with respect to separating linked and unlinked distances.     

The role of mobile computed tomography in mass fatality incidents

Mobile multi-detector computed tomography (MDCT) scanners are potentially available to temporary mortuaries and can be operational within 20 min of arrival. We describe, to our knowledge, the first use of mobile MDCT for a mass fatality incident. A mobile MDCT scanner attended the disaster mortuary after a five vehicle road traffic incident. Five out of six bodies were successfully imaged by MDCT in c. 15 min per body. Subsequent full radiological analysis took c. 1 h per case. The results were compared to the autopsy examinations. We discuss the advantages and disadvantages of imaging with mobile MDCT in relation to mass fatality work, illustrating the body pathway process, and its role in the identification of the pathology, personal effects, and health and safety hazards. We propose that the adoption of a single modality of mobile MDCT could replace the current use of multiple radiological sources within a mass fatality mortuary.     

Workplace violence: an overview of patterns of risk and the emotional/stress consequences on targets

Violence at work (VAW) is a frequent precursor to mental ill health, and to a lesser degree physical injury, among those exposed to this occupational hazard. In this paper an overview is provided of the nature and prevalence of such violence, of the risk factors involved, and of the impact upon victims. The paper examines the definition of VAW which includes both physical and psychological violence. Attention is given to the influential involvement of the UN affiliated International Labour Organisation in setting benchmarks for defining, preventing and responding to VAW. Evidence about the incidence and severity of VAW on a global basis is examined. It is noted that the reliability of information about VAW is quite variable, especially in non-industrialised countries. The available evidence indicates that psychological aggression is widespread across all sectors of employment and physical violence, although far less common, remains a significant problem. Risks of becoming a victim of VAW vary according to numbers of factors including job category, the nature of the work being performed, gender, age and experience. The paper also focuses on research regarding the effects upon persons experiencing or witnessing VAW. This research indicates that the health related consequences of psychological violence can be as severe as those from physical violence. The paper concludes that VAW is a major occupational health and safety hazard in all nations, regardless of their state of development. A reduction or elimination of this violence, and the health problems it creates, requires concerted and integrated strategies, together with rigorous evaluation of preventive measures.     

A Tale of Two Inquiries: Sans Everything and Ely

The government acknowledged scandalously poor care of long‐stay patients in National Health Service (NHS) hospitals in 1969. This followed the Ely Hospital inquiry, which emerged in the aftermath of revelations of abuse at seven hospitals described in Barbara Robb's book Sans Everything: A Case to Answer (1967). Allegations in Sans Everything and at Ely were similar. However, the inquiry committees which investigated, ‘disproved’ those in Sans Everything and upheld those at Ely. The Ely inquiry became pivotal to NHS policy reform for long‐stay mental illness and mental handicap hospitals, and for giving patients and their families a greater voice if they had concerns about inadequacies. This paper explains the relationship between Sans Everything and ‘Ely’ and analyses the impact of Robb's work—her high‐profile press campaign, networking, and determination to achieve improvement—which triggered revelations at Ely and elsewhere, and helped shape the course and constructive outcome of the Ely inquiry.     

Epistemic Communities: A Reply to Toke

This article contests the understanding of Peter M. Haas's 'epistemic communities' approach, forwarded by David Toke in his article in Politics of May 1999. It is argued that while Toke diagnoses the approach's failing correctly, the cause he identifies is off the mark. This particularly concerns his assertion of a positivist dogma underscoring the thesis, which is rejected as a misinterpretation of Haas. Rather, it is contended that the framework's inability to engage with the real world of politics, and the other groups therein, is a product of its lack of theoretical refinement and rigorous empirical examination.     

The experience of breast development and girls' stories about the purchase of a bra

Girls' experiences of secondary sexual characteristic development were explored via direct interview and protective techniques. In a pilot study (Study 1), 30 White middle to upper middle class 6th–8th-grade girls were interviewed about how they felt about breast and pubic hair growth, their comfort discussing these events, and their information acquisition. Breast growth was perceived as more important than hair growth, in part because the former is perceived as a more public event. Few girls reported intensely negative feelings to either change. Since responses to the direct questions were limited, 80 White 6th–9th graders were asked to tell a story (using a semi structured interview technique) about a picture of an adolescent girl, adult female, and adult male in which the adult female was taking a bra out of a shopping bag (Study 2). Affect, attitudes, and character alliances were coded. More girls attributed negative feelings to the father than to the mother character. Almost all girls describe the adolescent in the story as embarrassed. The daughter and father characters were described as uncomfortable more often than the mother character (50% vs. 10%). Positive maternal affect in the stories was associated with more advanced pubertal status, positive body images, more positive emotional tone, and lower anxiety scores. Affect ascribed to the father and daughter characters was less likely to be associated with girls' psychological functioning. Results are discussed in term sof the possible role of puberty upon parent-child relationships and communication.We wish to thank the W. T. Grant Foundation and the National Institute of Child Health and Human Development for their generous support of our research. This article was written while the first author was a Visiting Scholar at the Russell Sage Foundation; the support of the foundation is appreciated.Received Ph.D. from the University of Pennsylvania.Received M.D. from Columbia University.     

The Relationship between Human Needs and Criminogenic Needs

Abstract

Precipitators are personal attributes enhancing a person's likelihood of becoming criminally victimized. The present experiment focuses on walking style synchrony as a nonverbal determinant of differential perceptions. Findings suggest that walking styles associated with a lack of interactional synchrony - a lack of organized movement, a lack of ‘wholeness’, a lack of flowing motion - result in higher ratings of robbery potential and in lower ratings of perceived self-confidence of a target relative to more synchronous walking styles. Analyses also suggest that high criminal involvement is associated with more easily construing situations as ‘opportunistic’. Some implications for assertiveness and self-defense training programs are discussed.