体外培养FBs损伤模型的建立及细胞免疫组化研究

首次应用培养人胎肺成纤维细胞 (FBs)损伤模型 ,体外研究创缘FBs合成细胞型纤维连接蛋白 (cellu larfibronectins,cFn)的变化与损伤时间的关系。结果表明 ,损伤使处于静息状态的融合FBs成为具有运动能力和增殖能力的活跃细胞。应用免疫组化ABC法结合图像分析技术 ,观察伤后不同时间创缘FBs内cFn的含量变化。伤后 1h ,可以检测到cFn有变化 ,且在伤后 6h内 ,cFn逐渐增多 ,其变化与损伤时间呈正相关。这对今后应用cFn与损伤时间推断的研究提供了科学依据 ,同时为法医学损伤时间研究开辟了新的途径。     

大鼠肝细胞DNA含量与早期死亡时间关系的图像分析研究

实验选择 15只大鼠 ,处死后 ,在 2 4h内 ,每隔 1h取肝组织块进行细胞学涂片、福尔马林液固定、Feul gen染色、自动图像分析仪测量、统计学处理数据。结果表明 ,肝细胞DNA含量在死后 2 4h内 ,随死亡时间的延长而较有规律的下降。其中积分光密度、平均光密度、异形指数是用来研究死亡 2 4h内肝细胞DNA降解规律 ,并准确推断死亡时间的较好指标。     

损伤对培养人胎肺FBs分泌Fn的影响及与损伤时间的关系

为了探讨损伤对FBs分泌Fn的影响及与损伤时间的关系 ,在本室建立的体外培养人FBs损伤模型的基础上 ,应用酶联免疫组织化学检测技术 (双抗体夹心法ELISA)对损伤后不同时间培养液中Fn的含量变化进行检测 ,结果表明 :伤后培养人胎肺FBs合成分泌的cFn的量 ,在伤后6h内与损伤时间呈正相关。     

HIV/AIDS legal issues in the United States

The HIV/AIDS epidemic continues to be a leading public health issue in the United States. During the past decade, the epidemic has shifted away from the gay community, although gay and bisexual men continue to be the largest single HIV exposure category. Now, HIV increasingly affects low-income people of colour in urban areas, as well as women. As AIDS becomes more and more a minority, inner-city disease, public focus on the epidemic as a significant social and political issue is waning. While a full survey of current issues in US law is beyond the scope of this article, the focus here is on current issues that are highly relevant to the direction the epidemic appears to be taking.     

The business judgment rule and other protections for the conduct of not-for-profit directors

The authors review the Business Judgment Rule as applied to a not-for-profit director's duty of care, with particular emphasis on the different forms of state statutory liability shields that serve to enhance the protections of the Rule. They also examine current trends in enforcement of breach of fiduciary duty of care standards, and provide a series of specific recommendations for not-for-profit boards to consider implementing as a means of increasing the likelihood of affording such protections to individuals serving as directors.     

Managed care liability today: laws, cases, theories, and current issues

Managed care entities face numerous liability issues in today's changing healthcare environment. This Article provides the plaintiff with a comprehensive road map for navigating the many avenues of managed care liability. The author describes ERISA pre-emption provisions and suggests ways plaintiffs' attorneys can strive to narrow the pre-emption. The Article also provides in-depth analysis of each theory of managed care liability that has been litigated against managed care entities to date, and then goes on to explore state laws imposing liability on managed care entities, and how HMO liability is being reformed through legislative action. For plaintiffs' attorneys seeking the full spectrum of theories of managed care liability, or for defendants' attorneys wanting to remain updated on all potential claims to defend, this Article constitutes an extensive primer on the current issues.     

Bibliography

This Bibliography, covering items noticed between May and August1960, has been compiled wish the co-operation of Miss Ruth Jones(International African Institute) and Professor T. Heyse (latelyof the Belgian Ministry of Colonies).     

Bibliography

This Bibliography, including items noticed between Februaryand May. 1958. has been compiled with the assistance of MissRuth Jones (International African Institute) and Professor T.Heyse (lately of the Belgian Minister of Colonies)     

The belief systems of protesting college students

A group of 29 college students who had been arrested or nominated as having participated in a street disturbance aimed at producing social change were interviewed. The interview schedule was highly similar to one which had been used to investigate attitudes toward violence in a random, representative sample of American men. The data collected from the arrestees are compared with data from college students in the national sample. This study shows that the arrestees are more likely to think that violence is necessary to produce social change than are college students generally, and are more likely to believe that existing social institutions are inadequate. As a group, the arrestees are more identified with white student demonstrators and black protestors than are college students generally. The arrestees are also likely to regard the police as untrusworthy, looking for trouble, and apt to dislike people like themselves. In addition to the negative attitudes toward the police held by the student arrestees, they are more likely to regard police actions as violence (and hence provocative) than are other college students. The arrestees are far more likely than other college students to cleave to humanistic values. However, most of the differences between the arrestees and other American college students could be predicted from a general model of the justification of violence, so that it appears that the student activists' beliefs differ not so much in kind from those of other Americans as they do in degree.This research was funded by NSF Grants GS 2424 and GS 28295 under a project codirected by Monica D. Blumenthal, Robert L. Kahn, and Frank M. Andrews.Currently Program Director at the Institute for Social Research in the Survey Research Center, and Associate Professor of Psychiatry at the University of Michigan Medical School. Obtained M.D. from the University of Michigan Medical School and Ph.D. in physiology from the University of California, Berkeley. Currently engaged in social psychological research, with main interests focused on violence and the epidemiology of depressive disorders. Psychiatric interests are biologically oriented and focused on adult psychiatry.