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971.
Managing incidental findings in human subjects research: analysis and recommendations. 总被引:8,自引:8,他引:0
Susan M Wolf Frances P Lawrenz Charles A Nelson Jeffrey P Kahn Mildred K Cho Ellen Wright Clayton Joel G Fletcher Michael K Georgieff Dale Hammerschmidt Kathy Hudson Judy Illes Vivek Kapur Moira A Keane Barbara A Koenig Bonnie S Leroy Elizabeth G McFarland Jordan Paradise Lisa S Parker Sharon F Terry Brian Van Ness Benjamin S Wilfond 《The Journal of law, medicine & ethics》2008,36(2):219-48, 211
No consensus yet exists on how to handle incidental findings (IFs) in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are findings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. 相似文献
972.
Shaun L. Gabbidon Leslie K. Kowal Kareem L. Jordan Jennifer L. Roberts Nancy Vincenzi 《American Journal of Criminal Justice》2008,33(1):59-68
This paper examines race-based peremptory challenges. Such challenges occur during the voir dire jury selection process. The process allows both the defense and the prosecution to strike jurors who they believe will not
decide cases fairly. However, in the case of Batson v. Kentucky 476 U.S. 79 (1986), the Supreme Court ruled that race could not be used as a factor in eliminating prospective jurors. This
paper examines federal litigation for five years in which it was alleged that race was used as a factor in removing a juror.
An examination of the cases revealed that most of the cases involved sole male litigants who allege that there were multiple
race-based peremptory challenges used in their cases. Moreover, most of the cases that led to the allegations involved violent
offenses. Other case characteristics are noted, but of most significance was the finding that most appellants lost their cases.
As such, the courts felt that most of the challenges were, in fact, race neutral. The implications of this research are discussed.
This study was funded by an undergraduate research grant from Penn State University. 相似文献
973.
974.
GEOFFREY K. FRY 《Public administration》1991,69(4):423-438
Early access to the papers of the Fulton committee of 1966–8 and to the still unpublished oral evidence that the committee received, which has been Officially granted to the author, enables the contribution of its Management Consultancy Group to be studied fully for the first time, that study being complemented by interviews with the surviving members of the committee, its secretariat, and of the group. The article argues that the group was innovative in that, by means of its report, and through such impact as it had upon the Fulton committee and its report, it put the adoption of the bat private sector management practice into a prominent place on the Fabian socialist agenda for civil service reform and, hence, added an extra dimension to the Fabians' traditional concern about greater efficiency. 相似文献
975.
976.
David E. Winickoff 《The Journal of law, medicine & ethics》2007,35(3):440-456
A property analysis of the U.K. Biobank reveals a new imagination of the genomic biobank as a national common-pool resource. U.K. Biobank's treatment of property and governance exhibit both strengths and weaknesses that may be instructive to genome project planners around the world. 相似文献
977.
Three programs in BASIC and SUPER BASIC language for personal computer are suggested. The first program makes it possible to calculate the degree of substance extraction and factor of its distribution between two liquid immiscible phases. The second program is designed to make calculations on distribution of substance in the organs of experimental animals. The third program is designed to determine specific and molar factors of light absorption. Results of calculations are presented as tables. Programs can be also used in mathematical processing of results obtained in the course of scientific research. 相似文献
978.
Fifty-eight garments were taped and searched for mid to dark blue wool fibres. These were then removed from the tapings, mounted on slides and examined using a high-power microscope (400x). A total of 2,740 blue wool fibres were identified and visible range microspectrophotometry (MSP) was performed on them. Three hundred independent blue wool populations were identified on 56 of the 58 garments searched. The lack of control fibres meant the spectral range of each population was unknown. The number of populations may have been underestimated by grouping together the fibres that had broad single peaks and a lack of distinguishing features in the spectra. Although blue wool is considered to be a common fibre type, 300 unique spectral shapes were identified by the use of microspectrophotometry alone. This demonstrates that the dyes used in the dyeing of blue wool are variable. Showing that many different populations of blue wool occur on a range of garments should ensure that the forensic scientist does not underestimate or understate the strength of evidence in cases where blue wool is found. Hopefully this work will enlighten scientists and enable them to also assess the true value of their findings when other commonly occurring fibres are encountered. 相似文献
979.
A simple method was devised to assess dental attrition in terms of its area and number of sites by using dental plaster casts and a computer assisted image analyser. The changes presented on the occlusal surfaces of teeth were investigated for age estimation using these criteria. The area of attrition on each tooth demonstrated a significant positive correlation with age, but a wide individual variation was observed in the values for each tooth. Therefore, this method was unsuitable for accurate age estimation of a single tooth. A strong negative correlation with age was observed in the number of sites of attrition. A multiple stepwise regression analysis using the variables 'attrition area' and 'attrition number' revealed multiple correlation coefficient values of 0.93. The quantitative assessment of both horizontal and vertical factors of dental attrition would be essential to improve the accuracy of this method. 相似文献
980.
David Lee 《澳大利亚政治与历史杂志》2005,51(3):429-439
How did the Menzies Governments of the early to mid 1960s arrive at the position of sending Australian troops to Vietnam? During the 1950s, Menzies, and especially his External Affairs Minister Richard Casey, developed an appreciation of the strategic significance of Indochina, but struggled to view the conflict in Vietnam in ways other than through Cold War lenses. By the 1960s too, Britain's capacity to demonstrate a lead for Australia in foreign policy for the region was diminishing with its power, and the Menzies Governments were mindful of the need to support an American preparedness to intervene in Southeast Asia against communist‐led forces. This logic became more compelling in the face of Indonesia's “Confrontation” with Malaysia from 1963. As a result, the Liberals were not reluctant to support US military intervention in the region, in Vietnam. 相似文献