Aberrant MN bloodgroup inheritance in a German family: a 'silent' allele?

By means of extensive serogenetic testing of a family, RFLP analysis and biostatistic evaluation we present evidence for the rare transmittance of a 'silent' information at the MN blood group locus in a Caucasian family.     

Implementing regulatory reform: the saga of Michigan's debedding experiment

This paper traces the implementation of Michigan's program for hospital bed reduction through four phases in the critical first 30 months following enactment: standard-setting, plan development, plan approval, and legislative oversight. Procedural complexity and goal conflict complicated implementation from the start: what began as a simple proposal to close unneeded beds soon became enmeshed in efforts to address long-standing issues of equity in access to care. A combination of administrative, political, and economic factors peculiar to Michigan, as well as the more generic problems incurred in applying a regulatory approach to containing medical care costs, contributed to the difficulties encountered in implementing bed reduction. Long-range prospects for the program depend upon whether the modest results it is likely to achieve are deemed to be worth the costs incurred in administering it.     

Legal rules and the basis for evaluating economic losses

Damages or a loss in economic well-being can be measured by either the maximum sum people would pay to avoid the loss, or by the minimum compensation they would require to accept it. These alternative bases for evaluation have been assumed to yield fully equivalent measurements, and as a consequence no discrimination is usually made between them in assessment procedures. However, contrary to this presumption recent evidence from survey studies and from real exchange experimental tests shows that measures of values vary widely depending on which of the two bases is used. As an accounting of losses in economic welfare often figures prominently in the settlement of disputes and in the establishment of legal rules, this disparity can cause considerable ambiguity and lead to unintended and undesired outcomes: it can undermine negligence and nuisance determinations and project feasibility judgments, can bring about seriously incorrect assessments of losses and inadequate indemnification of damages, and can bias determinations over a range of other instances where measures of economic values are used.