Toxicologic aspects of deaths due to falls from height

A prospective study of 161 victims of falls from height is reported. The aim was to determine the interest of systematic qualitative and quantitative toxicological analysis in such fatalities. The primary cause of death was suicide (84.5%), followed by accidents (7%) and homicide (1%). In the remaining 7.5%, cause of death was undetermined. In the suicides, there was evidence of psychotropic medicines in 57% of the observations, with a much higher proportion of benzodiazepines and antidepressants in women than in men. Quantitative toxicologic analysis showed overdosing on medication in 16 suicide victims, with toxic levels in 11 of these. Systematic qualitative and quantitative toxicologic analysis made a significant contribution to the diagnosis of suicide by revealing either an unknown psychiatric treatment or a toxic level.     

Ordinary Sentences for Extraordinary Crimes

In comparison to sentences meted out by international tribunalsat Nuremberg, Tokyo and Arusha, and by domestic courts, sentenceshanded down at the International Criminal Tribunal for the formerYugoslavia (ICTY) have been inexplicably lenient. Factors thatmay have contributed to the high proportion of low sentencesat the ICTY include undue emphasis on mitigating factors, particularlythose of particular importance to the Tribunal, the use of pleaagreements, the absence of a separate sentencing hearing followingconviction and the practice of using global (rather than separate)sentences. To make sentences more proportionate to the crimescommitted, the objectives of sentencing should be clarifiedand re-evaluated. Greater weight should be given to deterrence.In assessing the gravity of the offence, the quantum of harmcaused to and suffering experienced by direct and indirect victimsof the crime merits more detailed evaluation. The importanceof mitigating circumstances (such as combating historical revisionism,pleading guilty, expressing remorse and voluntary surrender)should continue to be fully recognized but those factors shouldnot attract excessive weight. Plea bargaining and plea agreementsshould be encouraged because they are indispensable to the Tribunal,an institution with significant temporal, practical and resourcelimitations. The sentencing process should take place afterconviction. A sentencing Chamber should be obliged to statethe starting point of the sentence which it deems appropriateand then quantify the discounts it gives to each mitigatingfactor. Greater consideration should be given to imposing consecutiverather than concurrent sentences. The decision not to adoptsentencing guidelines represents a missed opportunity.     

Negative declarations in patent cases

The Patents Court has ruled that it has discretion to awarda claimant a negative declaration that its own product was obviousat the priority date of certain divisional applications. Thegrant of the declaration sought would assure the claimant thatit was not accruing ongoing liability.     

Population genetic study of eight short tandem repeat loci CSF1PO,TPOX, TH01, F13A01, FESFPS,vWA, F13B and LPL in the Western Romanian population

Allele frequencies for eight tetranucleotide short tandem repeat (STR) loci-CSF1PO, TPOX, TH01, F13A01, FESFPS, vWA, F13B, LPL-were obtained from a population sample of 105-122 unrelated individuals born in Transylvania and Banat (Romania).     

Etiology of pulmonary thromboembolism in the absence of commonly recognized risk factors

Pulmonary thromboembolism is an often fatal complication of venous thrombosis. Any component or combination of the components composing Virchow's triad (venostasis, hypercoagulability, and endothelial damage) increases the propensity for a thrombophilic state. Hypercoagulable states may be inherited or acquired. While the etiology in many cases may be evident either on physical examination or on evaluation of the decedent's medical history, this is often not the case. We conducted a retrospective study of cases presenting to the Jefferson County Coroner/Medical Examiner's Office in Birmingham, Alabama, who were given a diagnosis of pulmonary embolism. A search of cases within the past 23 years yielded 81 cases. An underlying cause was determined in 70 cases (86%). The remaining 11 (14%) cases had no identifiable cause. We believe that a number of these cases may represent an underlying thrombophilic disorder. Since these disorders may be of an inherited or acquired nature, the determination of an etiology may be relevant to the decedent's family. Postmortem blood analyses may in selected cases be useful and appropriate for the detection of some of these disorders. However, such analyses are not practical in all cases, with each case having to be evaluated on its own merits.     

Glyoxalase I typing and phosphoglucomutase-1 subtyping of a single hair

A technique is described for the typing of glyoxalase I (GLO I) and the subtyping of phosphoglucomutase-1 (PGM-1) from the root sheath cells of a single forcibly removed hair. This procedure does not require sample preparation and does not alter the morphological characteristics of the hair. The combined discrimination probability (DP) of the two markers taken together is 0.90 for whites and 0.89 for blacks. GLO I can be typed after four weeks, and PGM-1 can be typed after eight to fifteen weeks in hairs maintained at room temperature. Hairs mounted with Permount showed loss of enzyme activity and loss of band sharpness.