Direct analysis of anticonvulsant drugs in vitreous humour by HPLC using a column switching technique

A method is described for the rapid HPLC analysis of a number of anticonvulsant drugs in vitreous humour by injection directly onto a preconcentration column without the need for prior extraction. The conditions for optimum precision and accuracy were investigated and the method was subsequently applied to the analysis of phenytoin in a number of overdose cases. Sensitivity was 0.05 microgram/ml on a 0.5 ml vitreous sample. The mean blood/vitreous ratio for phenytoin was found to be 2.8 (range: 1.4-5.1). The relationship between blood and vitreous levels had a correlation coefficient of 0.85. Vitreous was found to be a very clean, stable sample, ideally suited to this technique.     

SURFACE MINING CONTROL AND RECLAMATION ACT: A UTAH PERSPECTIVE

The authority to regulate the coal industry a t the state level, under state statute and rules, the importance of the coal industry to the state, the importance of an environmentally sound regulatory program, and the benefit of a state-managed abandoned mine reclamation program, in short the ability of the state to manage its own natural resources, make state primacy a necessity, not an option.
Implementation of SMCRA cannot be measured in the myriad of oversight statistics. Effectiveness means cost-effective, timely reclamation of abandoned sites; consistent, workable rules and regulatory practices; responsive program management; and compliance which is internalized in the mine's operations.     

Identifying Urban Flashpoints: A Delphi-Derived Model for Scoring Cities’ Vulnerability to Large-Scale Unrest

Although great strides have been made toward forecasting state-level instability, little progress has been made toward the prediction of outbreaks of urban unrest. This article presents a method for the assessment of cities’ vulnerability to large-scale urban unrest. Forty-five factors correlated with urban unrest are identified and weighted by an expert panel. Based on expert elicitation through an iterative Delphi exercise, the explicitly methodological discussion describes both the process and the resulting assessment framework. Results include a tool that will allow users to rank cities on their vulnerability to large-scale urban unrest.     

Teaching and Assessing Oral Skills as Democratic Practice

Teaching and assessing oral skills is important, but relatively novel in the discipline of Political Studies; this article defends the practice, and outlines the 'nuts and bolts' of one methodology for doing it. Preliminary explanation in lectures, practice in seminars, assessment, feedback and self-assessment are all covered and the paperwork illustrated. The methodology is based in part on Habermas's theory of 'communicative competence' and the 'ideal speech situation'; it therefore implies and imparts the values of respect, equality, democracy and consensus. It is suggested that a value-free approach to the teaching of oral skills is impossible.     

PARTICIPATION AND APATHY IN TRADE UNIONS

Abstract: Trade union concern with participation in industry and in public decision-making has stimulated further interest in unions' own internal decision-making processes. This paper notes the low level of active membership involvement in the formal democratic procedures of most unions notwithstanding the very extensive legal framework and regulatory machinery on which these procedures rest. It also notes the higher degree of participation that sometimes exists on a more informal level, particularly in matters which directly affect terms and conditions of employment. Conditions conducive to membership participation or apathy are discussed and the implications of stability of incumbent leaders for participation by rank and file members are considered.     

Do Carrots Work? Examining the Effectiveness of EPA's Compliance Assistance Program

The role of compliance assistance in the U.S. Environmental Protection Agency's overall enforcement strategy has been quite variable over the past decade and a half, increasing in prominence under the Bush administration and now slated for significantly reduced funding under the Obama administration. While theoretical models and anecdotal evidence suggest that compliance assistance should play some role in a comprehensive enforcement strategy, to date there has been relatively little empirical evidence on the actual effectiveness of existing compliance assistance programs. To help inform the debate over the appropriate use of compliance assistance, this paper uses data on hazardous waste generators nationwide to assess the effect of federal compliance assistance programs in improving compliance with hazardous waste regulations. The paper also conducts a direct empirical analysis of the relationship between traditional enforcement tools and compliance assistance. The results show that federal compliance assistance efforts do increase compliance, but the evidence does not suggest any consistent relationship between traditional enforcement and compliance assistance. Also, while states do not appear to substitute federal compliance assistance for traditional enforcement, state compliance assistance programs do appear to decrease the likelihood of inspections among the smallest hazardous waste generators.