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21.
Sequence polymorphism in the human melanocortin 1 receptor gene as an indicator of the red hair phenotype. 总被引:14,自引:0,他引:14
We describe a minisequencing protocol for screening DNA samples for the presence of 12 mutations in the human melanocortin 1 receptor gene (MC1R), eight of which are associated with the red hair phenotype. A minisequencing profile which shows homozygosity for one of these mutations or the presence of two different mutations would strongly indicate that the sample donor is red haired. The absence of any red hair causing mutations would indicate that the sample donor does not have red hair. We report the frequencies of MC1R variants in the British red haired population. 相似文献
22.
John Dixon 《政策研究评论》1993,12(1-2):197-213
This paper examines the national provident funds (NPFs) that operate in 23 developing countries which seek to provide their members with basic social security protection by means of compulsory savings (see Appendix). It explores how the juxtaposition of economic, social and social security objectives has made NPFs generally resilient to fundamental change and has, in some instances, resulted in the evolution of a social security hybrid—neither a pure compulsory savings scheme nor a social insurance system. 相似文献
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Louise Dixon John Archer Nicola Graham‐Kevan 《Legal and Criminological Psychology》2012,17(2):196-215
Purpose. The ideologically based view of intimate partner violence has traditionally influenced policy and practice in modern western nations and dominated cross‐national research and practice. This review considers the validity of the position statement of a British organization responsible for accrediting many male perpetrator programmes in the statutory, voluntary, and private sector as an example of this ideological influence. Method. The position statement, informed by the patriarchal view of partner violence, is evaluated using empirical evidence from various branches of the social sciences, including psychology, that have not been guided by the patriarchal view. Results. Overwhelming empirical evidence is presented, which refutes ideologically driven assumptions that have been put forward to guide current practice and evaluation of it. Conclusions. This review highlights the need to investigate intimate partner violence from a scientific and gender‐inclusive perspective. The implications for psychological practice are discussed. 相似文献
26.
Analysis of artificially degraded DNA using STRs and SNPs--results of a collaborative European (EDNAP) exercise 总被引:4,自引:0,他引:4
Dixon LA Dobbins AE Pulker HK Butler JM Vallone PM Coble MD Parson W Berger B Grubwieser P Mogensen HS Morling N Nielsen K Sanchez JJ Petkovski E Carracedo A Sanchez-Diz P Ramos-Luis E Briōn M Irwin JA Just RS Loreille O Parsons TJ Syndercombe-Court D Schmitter H Stradmann-Bellinghausen B Bender K Gill P 《Forensic science international》2006,164(1):33-44
Recently, there has been much debate about what kinds of genetic markers should be implemented as new core loci that constitute national DNA databases. The choices lie between conventional STRs, ranging in size from 100 to 450 bp; mini-STRs, with amplicon sizes less than 200 bp; and single nucleotide polymorphisms (SNPs). There is general agreement by the European DNA Profiling Group (EDNAP) and the European Network of Forensic Science Institutes (ENFSI) that the reason to implement new markers is to increase the chance of amplifying highly degraded DNA rather than to increase the discriminating power of the current techniques. A collaborative study between nine European and US laboratories was organised under the auspices of EDNAP. Each laboratory was supplied with a SNP multiplex kit (Foren-SNPs) provided by the Forensic Science Service, two mini-STR kits provided by the National Institute of Standards and Technology (NIST) and a set of degraded DNA stains (blood and saliva). Laboratories tested all three multiplex kits, along with their own existing DNA profiling technique, on the same sets of degraded samples. Results were collated and analysed and, in general, mini-STR systems were shown to be the most effective. Accordingly, the EDNAP and ENFSI working groups have recommended that existing STR loci are reengineered to provide smaller amplicons, and the adoption of three new European core loci has been agreed. 相似文献
27.
The aim of the article is to convey to the reader the varietyof considerations that Defence Counsel before the InternationalTribunals must take into account when advising accused personsabout their pleas. Although there are no formally adopted sentencingguidelines for guilty pleas, certain practices and patternshave emerged in the jurisprudence. The article thus examinesthe host of mitigating and aggravating factors which the judgeshave identified in the sentencing judgments following guiltypleas. The plea-bargaining process is also discussed, in particularthe deviations between the sentences recommended in the agreementsbetween the Prosecution and Defence, and those handed down bythe Trial Chambersanother factor about which accusedpersons must be advised in deciding upon their pleas. The articleconcludes by highlighting the challenges faced by Defence Counselin applying the multiplicity of sentencing features to the factsof each case. 相似文献
28.
John Dixon 《Journal of Comparative Policy Analysis》1998,1(1):61-95
There has been dramatic global expansion in the national provision of social security programs throughout the twentieth century. This has provided very fertile ground for the comparative analysis of social security programs and systems over the last forty-five years. Most comparative studies, however, have, been content to describe and compare strategies, programs, institutions and values at the multinational or regional levels. There has been considerable reluctance either to engage in global studies or to embark on comparative-evaluative studies. This paper seeks to fill this gap by providing a framework for an evaluation methodology that permits the global ranking of social security systems and programs. 相似文献
29.
WELFARE IDEOLOGY, THE MARKET AND SOCIAL SECURITY: Towards a Typology of Market-Oriented Reform 总被引:1,自引:0,他引:1
The global shift towards the market in the provision of social security is typically associated with the values of the New Right, but we take issue with this view. An examination of the main welfare ideologies that have influenced the development of contemporary social security systems suggests that the market and individualism have a role to play in a range of approaches to reform. Whilst some approaches unreservedly endorse the market – in a way which accords with the ideas of the New Right – other approaches adopt a pragmatic orientation based on a recognition of two public policy dilemmas, “market failure” and “state failure.” This attempt to define a middle way typifies many of the recent social security reform initiatives. Drawing upon Esping‐Andersen's recent work on de‐commodification, we construct a typology of normative approaches to the provision of social security which may be used to contextualise market‐oriented social security reform initiatives. This we argue is necessary to avoid the over‐simplified dichotomy between individualism and collectivism which is typical of so much recent work on social security reform. 相似文献
30.
This paper explicates and reviews the competing approaches to policy analysis. It does so by constructing a methodological taxonomy that enables the identification of competing philosophical methodologies that underpin contending approaches to policy analysis. This is done by reference to contesting understandings of what constitutes knowledge (an epistemological issue) and what exists that is capable of giving rise to consequences (an ontological issue). This philosophical framework is then, illustratively, applied to an examination of the concept of the underclass. Then the epistemological and ontological challenges facing policy analysts seeking to analyze and address policy problems and issues are identified. Meeting these challenges requires the adoption of a methodology that draws insights from the epistemological and ontological syntheses that have emerged within contemporary social theory. 相似文献