Study of the correlation between psychiatric and psychological diagnoses in sample offenders

This study deals with the frequency with which expert psychiatrists and psychologists make structural or nosographic diagnoses within the context of expert assessment.Thus, the rates of concordance between psychiatrists and psychologists in both types of diagnoses will be assessed.To do so, the level of inter-observer agreement on diagnoses between 1990 and 2003 was studied retrospectively in France through psychiatric and psychological assessments of 505 male offenders. The assessment of the correlation rates was carried out using the Kappa coefficient.The results show a range of 0.55 to 0.71 in inter-observer (psychiatrists vs psychologists) agreement for structural diagnoses, and 0.51 to 0.89 for nosographic diagnoses.In addition, a marked correlation between psychiatrists and psychologists may be noted regarding abstention in both structural (k = 66) and nosographic (k = 73) diagnoses. In fact, recommendations are made for improvement in the consistency of offender assessment in the psycho-legal French context.     

Craniofacial reconstruction as a prediction problem using a Latent Root Regression model

In this paper, we present a computer-assisted method for facial reconstruction. This method provides an estimation of the facial shape associated with unidentified skeletal remains. Current computer-assisted methods using a statistical framework rely on a common set of extracted points located on the bone and soft-tissue surfaces. Most of the facial reconstruction methods then consist of predicting the position of the soft-tissue surface points, when the positions of the bone surface points are known. We propose to use Latent Root Regression for prediction. The results obtained are then compared to those given by Principal Components Analysis linear models. In conjunction, we have evaluated the influence of the number of skull landmarks used. Anatomical skull landmarks are completed iteratively by points located upon geodesics which link these anatomical landmarks, thus enabling us to artificially increase the number of skull points. Facial points are obtained using a mesh-matching algorithm between a common reference mesh and individual soft-tissue surface meshes. The proposed method is validated in term of accuracy, based on a leave-one-out cross-validation test applied to a homogeneous database. Accuracy measures are obtained by computing the distance between the original face surface and its reconstruction. Finally, these results are discussed referring to current computer-assisted reconstruction facial techniques.     

Analysis of ancient human DNA and primer contamination: one step backward one step forward

The analysis of DNA from archaeological human remains is plagued by a unique set of methodological problems concerning contamination with modern exogenous DNA. Through an original approach, we propose complementary methods to identify all potential sources of contamination and complete guidelines for the validation of ancient human sequences. The study presented was conducted on non-European human samples (Polynesian and Amerindian) which were collected with all precautions during excavation. This permitted us to distinguish without ambiguity authentic and contaminant sequences. The samples' origins and histories were perfectly known, allowing us to trace all potential contamination sources and to determine the efficiency of precautions followed during all steps of the study. The data obtained confirm that precautions taken during sampling effectively prevent contamination. However, we demonstrate that human contamination can also be introduced during genetic analyses even if all precautions are strictly followed. Indeed, numerous human contaminations were detected in template-PCR products and negative controls, resulting in a striking diversity of contaminant mitochondrial DNA sequences. We argue that this contamination partly derives from the primers. To our knowledge, no previous experiment has been performed to investigate primers as a possible source of human contamination despite the fact that this specific type of contamination poses a real problem in terms of validating ancient human DNA studies. Finally, we confirm that the detection of contaminants in negative controls is clearly related to the number of PCR cycles used. This study enhances our understanding of contamination processes and confirms that, in reality, an absolutely contamination-free situation cannot be obtained. As a consequence, we propose improvements to the guidelines usually followed in the field in order to take the highly probable contamination of PCR reagents, including primers, into account.     

Triggers for alcohol‐related violence in young male offenders

Purpose. Improving the effectiveness of offender treatment programmes is important and one approach is to attend to their content. The aim here was to identify triggers to alcohol‐related violence to inform the development of programmes to treat this problem. Method. Information from 149 young male offenders’ accounts of incidents of alcohol‐related violence was studied using thematic analysis. Results. Sixteen triggers for violence were identified and these were organized into six themes: (1) being offended by someone, (2) seeing an opportunity for material gain, (3) seeing others in need of help, (4) perception of threat, (5) distress, and (6) wanting a fight. Discussion. The implications of the results for developing treatments for alcohol‐related violence are presented. First, identifying triggers should be part of the treatment programme and ways of avoiding triggers should be addressed. Second, changing values, specifically hypermasculine and antisocial values, could attenuate the rewards signalled by the triggers. Third, methods of reducing the potency of triggers would be of value and would include addressing issues of need for respect and responses to perceived disrespect. Fourth, non‐violent ways of helping people who are in trouble need to be introduced. Fifth, coping with threat cues through distraction and increasing self‐awareness would reduce the effects of ‘alcohol myopia’. Sixth, seeking fights for excitement could be reduced by examining the costs through motivational procedures. Finally, and self‐evidently, a primary target of treatment programmes to reduce alcohol‐related violence should be to reduce the level and frequency of alcohol intoxication.     

From Conflict to Autonomy: The Making of the South Ossetian Autonomous Region 1918–1922

The article investigates the reasons that led the Bolsheviks to grant autonomous status to South Ossetia in 1922. The conflict between Ossetians and Georgians during the civil war started as a social dispute but rapidly turned into an ethnic confrontation. The Ossetians turned to the Bolsheviks for support, but by 1920 they were defeated and largely expelled from their territory. After the Sovietisation of the region in 1921 the Bolsheviks needed to solve the conflict: the solution adopted was to grant autonomous status. This was not—as is often believed—the result of a divide et impera policy but an attempt at conflict resolution that in the long run satisfied neither side.     

La guerre vue d'Ochollo (Éthiopie méridionale)

La quête pour la reconnaissance de la subjectivité et la dignité est au coeur des mouvements sociaux actuels. Les Africains se battent pour obtenir la reconnaissance depuis l’époque où la traite des esclaves et plus tard la colonisation les ont dépouillés de leurs qualités humaines. Ces combats ont été essentiellement révélés par l’écriture et le monothéisme. L’article actuel suggère aux lecteurs de considérer la construction performative du moi où la subjectivité Africaine / Noire est représentée dans toute son autonomie. L’exemple empirique proposé est celui de l’Afrique centrale.     

Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimes

The number of reports on drug facilitated crimes is increasing these last years. Apart from ethanol and cannabis, benzodiazepines (BZD) and analogs are the most common drugs reported to be used probably due to their amnesic and sedative properties. We have developed a rapid and sensitive method using LC-MS/MS triple stage quadrupole (TSQ) for the determination of single exposure to bromazepam (Lexomil, 6 mg) and clonazepam (Rivotril, 2 mg) in urine and hair of healthy volunteers. Chromatography was carried out on a Uptisphere ODB 5 microm, 2.1 mm x 150 mm column (Interchim) with a gradient of acetonitrile and formate 2 mM buffer, pH 3. Urine was extracted with Toxitube A (Varian) and allowed the detection of bromazepam, 3-hydroxy-bromazepam, clonazepam and 7-Aminoclonazepam for more than 6 days. Head hair, collected 1 month after the exposure, was treated by incubation with Soerensen buffer pH 7.6, followed by liquid-liquid extraction with dichloromethane for common BZD. A specific pre-treatment for amino-BZD, with an incubation of 15 min at 95 degrees C in 0.1 N NaOH before liquid-liquid extraction with dichloromethane, gave better recoveries and repeatability. After single exposure, bromazepam was present in powdered hair at 28 pg/mg and 7-Aminoclonazepam at 22 pg/mg in the first 1-cm segment, while no clonazepam was detectable. This method was applied in two forensic cases. It allowed us to determine bromazepam in urine 3 days after the alleged offense and in cut head hair at a concentration of 6.7 pg/mg only in the 2-cm proximal segment. The other case showed the presence of clonazepam and 7-Aminoclonazepam in urine a few hours after the offense and the presence of 7-Aminoclonazepam at about 3.2 pg/mg in axillary hair 4 months later.     

Testing for zopiclone in hair application to drug-facilitated crimes

The use of a drug to modify a person's behaviour for criminal gain is not a recent phenomenon. However, the recent increase in reports of drug-facilitated crimes (sexual assault, robbery) has caused alarm in the general public. The drugs involved can be difficult to detect due to low dosages or chemical instability. They possess amnesic properties and can be quickly cleared from the body fluids. In these situations, blood or even urine can be of poor interest. This is the reason why this laboratory developed an original approach based on hair testing by LC-MS/MS. Zopiclone (Imovane), due to its short half-life associated with rapid hypnotic activity, is considered as a compound of choice to sedate victims. To document the detection of zopiclone in hair, we first tested specimens obtained from two volunteers who had ingested a single 7.5 mg Imovane tablet, and from repetitive consumers of zopiclone. After pH 8.4 buffer incubation and extraction with methylene chloride/diethyl ether (80/20 (v/v)), hair extracts were separated on a Xterra MS C18 column using a gradient of acetonitrile and formate buffer. Zopiclone and diazepam-d5, used as internal standard, were detected by tandem mass spectrometry. A single exposure to zopiclone was detectable in the first hair segment of two volunteers at concentration of 5.4 and 9.0 pg/mg, respectively. Hair from repetitive consumers tested positive for zopiclone at concentrations of 37 and 66 pg/mg. Hair analysis was applied to two authentic criminal cases. In the first one, zopiclone tested positive in the corresponding hair segment at 4.2 pg/mg, in accordance with a single exposure to the drug. In the other expertise, zopiclone was detected in the two segments analyzed, at 21.3 and 21.5 pg/mg, making unlikely the hypothetical single exposure to zopiclone.