The Management of Incidental Findings in Neuro-Imaging Research: Framework and Recommendations

This paper addresses the question of how incidental findings (IFs) in clinical research should be managed by researchers, focusing in detail on IFs discovered in neuroimaging research. It begins by engaging the larger research ethics issue of whether researchers have any obligations of clinical care to participants, and assesses the content and merits of one particular framework for answering this question, Richardson and Belsky's ancillary care model. From here the paper develops an organizational structure for integrating the ancillary care model with existing research ethics standards, with the aim of better understanding their respective domains. It makes a distinction between incidental findings that are anticipated by informed consent documents, and those that are unanticipated, arguing that this distinction is critical for evaluating researcher obligations. Finally, it takes on the issue of incidental findings in neuroimaging research, translating the standards discussed into recommendations for both unanticipated and anticipated findings.     

The Impact of Socialisation on Graduates’ Public Service Motivation – a Mixed Method Study

The need to attract and retain a high calibre cadre of public servants today has resulted in a renaissance of interest in public service motivation (PSM) within public management literature. This article outlines a study of PSM with graduate employees within an Australian public sector. The study extends our understanding of PSM by adopting a longitudinal, mixed method design, including surveys and individual interviews, to consider the effects of socialisation on levels of PSM. Results show an organisation's mission and values do not affect individual PSM while work type and communication style is vital and organisational socialisation can provide a negative influence.     

Keeping Up with the Souzas: Social Influence and Electoral Change in a Weak Party System,Brazil 2002–2006

Despite weak partisanship and considerable political change in the wake of the 2002 election, three‐quarters of Brazilian voters supported a presidential candidate in 2006 from the same party they had backed in 2002. This article assesses the factors causing both electoral stability and electoral change with a transition model, a model testing whether the effects of respondents' evaluative criteria depend on their initial vote choices. Social context—personal discussion networks, neighborhood influences, and the interactions of social networks and municipal context—is the major force promoting stability and change, while the impact of partisanship is limited to a small share of voters.     

Headspace concentrations of explosive vapors in containers designed for canine testing and training: theory, experiment, and canine trials

It is a common misconception that the amount of explosive is the chief contributor to the quantity of vapor that is available to trained canines. In fact, this quantity (known as odor availability) depends not only on the amount of explosive material, but also the container volume, explosive vapor pressure and temperature. In order to better understand odor availability, headspace experiments were conducted and the results were compared to theory. The vapor-phase concentrations of three liquid explosives (nitromethane, nitroethane and nitropropane) were predicted using the Ideal Gas Law for containers of various volumes that are in use for canine testing. These predictions were verified through experiments that varied the amount of sample, the container size, and the temperature. These results demonstrated that the amount of sample that is needed to saturate different sized containers is small, predictable and agrees well with theory. In general, and as expected, once the headspace of a container is saturated, any subsequent increase in sample volume will not result in the release of more vapors. The ability of canines to recognize and alert to differing amounts of nitromethane has also been studied. In particular, it was found that the response of trained canines is independent of the amount of nitromethane present, provided it is a sufficient quantity to saturate the container in which it is held.     

Verdict selection processes in insanity cases

Judicial instructions (traditional American Law Institute vs. Guilty But Mentally Ill [GBMI]) were manipulated within an insanity defense vignette portraying a highly psychotic defendant. Construals were highly predictive of verdicts in both instructional conditions. Instead of influencing case construals, the GBMI option seems to operate by increasing respondents' decisional thresholds for insanity and guilty verdicts, creating a collapsing effect such that few such verdicts are rendered. Between-instruction comparisons reveal that the construals of respondents who choose insane and guilty verdicts are considerably more homogeneous and extreme under the GBMI conditions. Results suggest that many respondents intend their GMBI verdicts to signify diminished blame and punishment, indicating that such verdicts entail cognitive compromises that reflect both the thresholdraising effects and also probable confusion about the jurisprudential meaning of a GBMI verdict.This article is an expanded version of a paper entitled Insanity case construals are not simply verdict justification effects, which was presented at the 99th annual convention of the American Psychological Association at San Francisco, August, 1991. We would like to thank Linda Roberts, Norman Finkel, and the anonymous reviewers for their comments on an earlier version of this paper. Support for this research was provided in part by a grant from the Baldy Center on Law and Social Policy at the State University of New York at Buffalo.     

Evaluation and quantification of nuclear DNA from human telogen hairs

Nuclear DNA was extracted from human telogen hairs from 60 individuals. Six to nine hairs from each individual were individually extracted. The amount of DNA recovered from each individual varied greatly, and most samples yielded a quantity of 550 pg or less per hair. A selective extraction buffer was used to remove epithelial cell DNA and the amount of exogenous DNA was determined. DNA was also quantified by real time PCR using three different sized amplicons targeting an Alu sequence. The results were used to determine the state of degradation of the extracted DNA. Different quantities of sample (<100 pg, 100-500 pg, >500 pg) were amplified with the Miniplex kits to determine the minimum DNA template required for successful amplification. DNA recovered from hair showed degradation; however, partial profiles were obtained for those samples containing at least 60 pg using MiniSTRs.     

Change in treatment has no relationship with subsequent re-offending in U.K. domestic violence sample: a preliminary study

In this study, data is presented from a sample of 52 male domestic violence offenders who were court mandated to attend a profeminist psycho-educational rehabilitation program in the West Midlands. The extent of both statistically and clinically significant psychological change achieved across a variety of measures (pro-domestic-violence attitudes, anger, locus of control, interpersonal dependency) assessed pre- and post-treatment, and their association with post-treatment re-offending within an 11-month follow-up period is examined. The results indicate that program completers achieved limited significant psychological change. However, the level of psychological change achieved had no association with re-offending.     

Acts of Childhood Sexual Abuse: An Empirically Derived Typology

A clinical sample of 165 women survivors in outpatient therapy was surveyed about whether their childhood sexual abuse (CSA) included each of 17 sexual acts. Factor analysis of these acts was conducted. A typology of CSA acts consisting of three factors emerged. Inspection of the acts loading on each factor suggested that they differed primarily in terms of the type of abuse of power implied by them rather than in the nature of the sexual behavior involved. The three factors were named Coerced Complicance (Coercion), Subjugation and Humiliation (Subjugation) and Invasive Objectification (Objectification). Implications for research, theory, and clinical practice, and the need for evaluating the generalizability of the typology to other subpopulations of survivors, are discussed.