Vascular changes in the nasal submucosa of chronic cocaine addicts

A detailed, correlative, histologic evaluation of postmortem changes in the nasal mucosa of chronic cocaine users has shown characteristic mucosal and arteriolar changes as well as typical perivascular and subepithelial alterations compatible with chronic inflammation. These findings confirm and extend recent reports on the effects of cocaine in the coronary circulation and heart muscle as well as provide a new diagnostic tool to the forensic pathologist who suspects that a decedent has been a long-term cocaine abuser.     

The general toxicology unknown. II. A case report: doxylamine and pyrilamine intoxication

A general toxicology unknown case is presented to demonstrate our systematic approach. A 20-year-old male was found dead with multiple suicide notes. Overdose was suspected but substances were not known. Blood alcohol was negative. Urine was analyzed by enzyme-multiplied immunoassay technique and was negative for all drugs assayed. Urine was then extracted with ethyl acetate:hexane (1:1) at pH 10 and back-extracted into 1.0N sulfuric acid. The acidic layer was adjusted to pH 10, and re-extracted with ethyl acetate:hexane (1:1). The residue was analyzed by gas chromatography (GC) on a 3% OV-101 column. It was found to be negative for all commonly screened substances. However, several unknown peaks were observed. Electron impact mass spectra of these unknown peaks were obtained and searched for in our computer library of more than 25000 mass spectra. These unknown peaks were identified as doxylamine and pyrilamine by gas chromatography/mass spectrometry. The base peak and molecular ion for pyrilamine were at m/z 121 and 285, respectively. The base peak for doxylamine was at m/z 58. No molecular ion was observed for doxylamine. Both doxylamine and pyrilamine are antihistamines, but are promoted and used in the management of insomnia. Quantitation was performed on a GC using dexbrompheniramine as an internal standard. Blood concentrations for doxylamine and pyrilamine were 0.7 and 7.0 mg/L, respectively. Concentrations in other tissues were determined. Death was caused by combined doxylamine and pyrilamine intoxication; the manner of death was suicide.     

Use of Embryos Extracted from Individual Cannabis sativa Seeds for Genetic Studies and Forensic Applications

Legal limits on the psychoactive tetrahydrocannabinol (THC) content in Cannabis sativa plants have complicated genetic and forensic studies in this species. However, Cannabis seeds present very low THC levels. We developed a method for embryo extraction from seeds and an improved protocol for DNA extraction and tested this method in four hemp and six marijuana varieties. This embryo extraction method enabled the recovery of diploid embryos from individual seeds. An improved DNA extraction protocol (CTAB3) was used to obtain DNA from individual embryos at a concentration and quality similar to DNA extracted from leaves. DNA extracted from embryos was used for SSR molecular characterization in individuals from the 10 varieties. A unique molecular profile for each individual was obtained, and a clear differentiation between hemp and marijuana varieties was observed. The combined embryo extraction–DNA extraction methodology and the new highly polymorphic SSR markers facilitate genetic and forensic studies in Cannabis.     

Globalisation of Commodification: Legal Process Outsourcing and Indian Lawyers

Legal process outsourcing (LPO) refers to the contracting of legal work from regions where it is costly to perform, such as the US to areas where it can be performed at a significantly decreased cost. LPO has been made possible by the disaggregation of the legal processes into discrete units, each of which can then outsourced to cheaper service providers. Anecdotal evidence suggests a variety of benefits such as financial gains, opportunities to perform “global” work in a corporate atmosphere and acquisition of important skills and training that enhances the prestige of the host country lawyers. In India, which has played a significant role, LPO firms are viewed as important catalysts in the transformation of the country’s highly stratified legal profession based on social identities. This qualitative study, based on 38 interviews, concludes that the corporate culture was an attractive proposition for lawyers from non-elite backgrounds; however, the commodification of offshored work led to a deprofessionalisation of lawyers, reducing them to “glorified clerks.” As a result, LPO firms only provided parallel avenues for career mobility but did not destabilise the local legal market which at its core remains socially networked.     

Indian Public Sector Trade Unionism in Context: Gujarat and West Bengal Compared

Using qualitative research methods and comparing two Indian states (Gujarat and West Bengal), the authors examine the relative power and influence of trade unions in three parts of the public sector, viz., state government employment, municipal bus and tram services, and telecommunications. The distinctive methodology and the findings emphasise the importance of caution in generalising about trade unionism and industrial relations in India as a whole; and indicate that the context of particular Indian states is a vital ingredient of trade union analysis. The authors identify a complex web of explanatory factors for the relative power and influence of the unions under study, within the distinctive political, economic and historical contexts of Gujarat and West Bengal. Thus, they demonstrate the largely untapped potential for primary, qualitative and comparative research to expand our understanding of industrial relations in India.     

Tenure Insecurity,Gender, Low-cost Land Certification and Land Rental Market Participation in Ethiopia

There is a renewed interest in whether land reforms can contribute to market development and poverty reduction in Africa. This paper assesses effects on the allocative efficiency of the land rental market of the low-cost approach to land registration and certification of restricted property rights that was implemented in Ethiopia in the late 1990s. Four rounds of a balanced household panel from 16 villages in northern Ethiopia are analysed, showing that land certification initially enhanced land rental market participation of (potential) tenant and landlord households, especially those that are headed by females.     

Evaluating the Cost of Organised Crime from a Comparative Perspective

Whilst any estimation of crime costs is a challenge even at a national level and in respect to crimes not particularly problematic from the definitional viewpoint, like volume crimes, the task is much harder when one has to deal with the harm caused by organised crime, especially from a comparative perspective. First, notwithstanding many international acts and studies, the term ‘organised crime’ is still one of those most debated and blurred in criminology. To complicate matters further, any cross-country assessment encounters such a wide variety of national differences (cultural, in the definition of offences, and in crime data collection systems) that the results are hardly comparable. Though extremely difficult, discussing the topic makes a great deal of sense today, and especially within the European Union, because there is strong demand for sound knowledge on the most harmful activities perpetrated by organised criminal groups and where these are localised. Considering the increasing importance attached to the issue, this article critically discusses existing attempts to measure organised crime harm from a comparative perspective, highlighting their strengths and weaknesses. It first reviews harm assessment models developed to date at the international level, and mainly consisting of surveys. It then presents a different approach to the subject, one more centered on official statistics and which has recently resulted in the development of a methodology in the context of a EU-funded study entitled IKOC (Improving Knowledge on Organised Crime to develop a common European approach).